β-Adrenergic receptor distribution in human and rat hippocampal formation: marked species differences

Duncan, Gary E.; Little, Karley Y.; Koplas, Patricia A.; Kirkman, Jacob A.; Breese, George R.; Stumpf, Walter E.

doi:10.1016/0006-8993(91)90752-h

Cited by 39 publications

(23 citation statements)

References 25 publications

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“…Vulnerability of the hippocampus can be expected to occupy a fairly wide developmental window, given the fact that neurogenesis and synaptic remodeling continue into adolescence in this region (McWilliams and Lynch, 1983;Altman and Bayer, 1990). It is of particular importance that the human hippocampus has a high concentration of ␤ 2 ARs, the specific subtype mediating the effects of terbutaline (Duncan et al, 1991).…”

Section: Discussionmentioning

confidence: 99%

Terbutaline Is a Developmental Neurotoxicant: Effects on Neuroproteins and Morphology in Cerebellum, Hippocampus, and Somatosensory Cortex

Rhodes

Seidler²,

Abdel-Rahman³

et al. 2003

J Pharmacol Exp Ther

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␤ 2 -Adrenoceptor agonists, especially terbutaline, are widely used to arrest preterm labor, but they also cross the placenta to stimulate fetal ␤-adrenoceptors that control neural cell differentiation. We evaluated the effects of terbutaline administration in neonatal rats, a stage of neurodevelopment corresponding to human fetal development. Terbutaline administered on postnatal days PN2 to 5 elicited neurochemical changes indicative of neuronal injury and reactive gliosis: immediate increases in glial fibrillary acidic protein and subsequent induction of the 68-kDa neurofilament protein. Quantitative morphological evaluations carried out on PN30 indicated structural abnormalities in the cerebellum, hippocampus, and somatosensory cortex. In the cerebellum, PN2 to 5 terbutaline treatment reduced the number of Purkinje cells and elicited thinning of the granular and molecular layers. The hippocampal CA3 region also displayed thinning, along with marked gliosis, effects that were restricted to females. In the somatosensory cortex, terbutaline evoked a reduction in the proportion of pyramidal cells and an increase in smaller, nonpyramidal cells; again, females were affected more than males. Although abnormalities were obtained with later terbutaline treatment (PN11 to 14), in general the effects were smaller than those seen with PN2 to 5 exposure. Our results indicate that terbutaline is a neurotoxicant that elicits biochemical alterations and structural damage in the immature brain during a critical period. These effects point to a causal relationship between fetal terbutaline exposure and the higher incidence of cognitive and neuropsychiatric disorders reported for the offspring of women receiving terbutaline therapy for preterm labor.

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Section: Discussionmentioning

confidence: 99%

Terbutaline Is a Developmental Neurotoxicant: Effects on Neuroproteins and Morphology in Cerebellum, Hippocampus, and Somatosensory Cortex

Rhodes

Seidler²,

Abdel-Rahman³

et al. 2003

J Pharmacol Exp Ther

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“…Nicholas et al (1993) reported that both ␤1-and ␤2-ARs reside in the rat hippocampus, with ␤1-AR mRNA a light labeling and ␤2-AR mRNA a moderate labeling in the CA1 stratum pyramidale. Duncan et al (1991) reported that the ventral subiculum and entorhinal cortex in the rat have the highest density of ␤-AR. Jurgens et al (2005) reported that ␤1-AR labeling was present on the pyramidal cells in the hippocampus and the heaviest labeling was observed along the plasma membrane and within the cytoplasm of cells in the CA3 region.…”

Section: Discussionmentioning

confidence: 99%

Cellular and subcellular distributions of β1- and β2-Adrenoceptors in the CA1 and CA3 regions of the rat hippocampus

Guo¹,

Li²

2007

Neuroscience

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Abstract-␤-Adrenoceptors (ARs) in the hippocampus play an important role in regulating synaptic plasticity and memory consolidation. However, little is known about the distributions of ␤-ARs in the hippocampus, especially in the cornu ammonis (CA)1 and CA3 regions of Sprague-Dawley rats. Here, we report that ␤1-and ␤2-ARs in the CA1 and CA3 regions have differential subcellular distributions. Using double immunofluorescence labeling and confocal laser scanning microscopy, we found that almost all of the neuronal nuclei positive cells express ␤1-and ␤2-ARs, while few glial fibrillary acidic protein positive cells express them. Interestingly, ␤1-ARs are predominantly distributed in the cell membrane and cytoplasm, whereas ␤2-ARs are predominantly distributed not only in the membrane and cytoplasm, but also in the nucleus. The differential subcellular distribution of ␤1-and ␤2-ARs may have functional significance.

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“…Obviously, the discrepancies in the basal binding could also be due to differences between both species in the diverse contribution of the multiple types of GPCR to the basal activity and their anatomical distribution. That is the case with some receptors such as the luteinizing-hormone-releasing receptor, adenosine A1, a1 and b adrenoceptors, dopamine D2, 5-HT 1A and cholecystokinin-octapeptide among others which have been described as having different densities in human and rat SNC Fastbom et al, 1987;Reubi et al, 1987;Kohler and Chan-Palay, 1988;Kohler et al, 1991;Duncan et al, 1991Duncan et al, , 1998Little et al, 1992;Berkowitz et al, 1994). However, it is also possible that there are differences in the efficiency of the coupling and/or the effector proteins (González-Maeso et al, 2002).…”

Section: Discussionmentioning

confidence: 92%

“…Further studies are necessary to clarify the efficiency of selective compounds for GAL receptors. The rat has been used as an experimental model for neuropharmacological research of the galaninergic system and numerous ligands for neurotransmitter receptors, including GAL, present similar binding affinities and pharmacological selectivity in both rats and humans Duncan et al, 1991;Branchek et al, 2000). Previous studies had also shown the existence of substantial differences between these two species regarding the regional distribution of neurotransmitter receptors in the brain (Kohler and Chan-Palay, 1988;Duncan et al, 1991Duncan et al, , 1998Little et al, 1992).…”

Section: Discussionmentioning

confidence: 98%

Galanin activated Gi/o-proteins in human and rat central nervous systems

2014

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β-Adrenergic receptor distribution in human and rat hippocampal formation: marked species differences

Cited by 39 publications

References 25 publications

Terbutaline Is a Developmental Neurotoxicant: Effects on Neuroproteins and Morphology in Cerebellum, Hippocampus, and Somatosensory Cortex

Terbutaline Is a Developmental Neurotoxicant: Effects on Neuroproteins and Morphology in Cerebellum, Hippocampus, and Somatosensory Cortex

Cellular and subcellular distributions of β1- and β2-Adrenoceptors in the CA1 and CA3 regions of the rat hippocampus

Galanin activated Gi/o-proteins in human and rat central nervous systems

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