β-Adrenergic receptors on murine lymphocytes: Density varies with cell maturity and lymphocyte subtype and is decreased after antigen administration

Fuchs, Bruce A.; Albright, Julia W.; Albright, Joseph F.

doi:10.1016/0008-8749(88)90318-8

Cited by 106 publications

(42 citation statements)

References 25 publications

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“…Compared to mature T cells, unfractionated thymocytes express very low levels of high-affinity β-AR [53]. Mature corticosteroneresistant thymocytes express β-AR at levels equivalent to those seen in peripheral T cell populations [54,55]. These data suggest that β-AR expression is limited on immature thymocytes, but increases as thymocytes mature and differentiate.…”

Section: Sympathetic Neurotransmission In the Thymusmentioning

confidence: 78%

“…Human and murine T lymphocytes express β 2 -AR [54,55,[126][127][128][129][130][131][132][133][134][135][136][137][138][139][140]. T helper (Th)1 and Th2 cell clones generated from naïve cells differentially express β 2 -AR [141].…”

Section: T Lymphocytesmentioning

confidence: 99%

“…Studies using activated splenic or lymph node T cells have reported either increased [55,134,143] or decreased [55,144] β 2 -AR expression 24 h after activation with either Con A or phorbol 12-myristate-13-acetate (PMA)/calcium ionophore. Contact sensitization increases expression of β-AR in murine draining lymph node cells [145]; however, immunization with a Th cell-dependent antigen significantly decreases β-AR expression in unfractionated spleen cells [54]. Variability in the absolute numbers of β-AR per cell reported may result from different experimental conditions, such as the T cell isolation techniques, source of T cells, types of radiolabel used to tag pharmacological ligands, using ligands with different affinities, or specific activity of the radioligand.…”

Section: T Lymphocytesmentioning

confidence: 99%

“…Based on radioligand binding and RT-PCR studies, B cells express a higher density of β-AR than CD4 + Th cells [54,126,129,131,133,[157][158][159]. These receptors are of the β 2 -AR subtype [54,129,131,160] and their stimulation also elevates intracellular concentrations of cAMP [127,131,[135][136][137]148,160].…”

Section: B Lymphocytesmentioning

confidence: 99%

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Sympathetic modulation of immunity: Relevance to disease

Bellinger

Millar

Perez

et al. 2008

Cellular Immunology

227

185

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Optimal host defense against pathogens requires cross-talk between the nervous and immune systems. This paper reviews sympathetic-immune interaction, one major communication pathway, and its importance for health and disease. Sympathetic innervation of primary and secondary immune organs is described, as well as evidence for neurotransmission with cells of the immune system as targets. Most research thus far as focused on neural-immune modulation in secondary lymphoid organs, and have revealed complex sympathetic modulation resulting in both potentiation and inhibition of immune functions. SNS-immune interaction may enhance immune readiness during disease-or injury-induced 'fight' responses. Research also indicate that dysregulation of the SNS can significantly affect the progression of immune-mediated diseases. However, a better understanding of neural-immune interactions is needed to develop strategies for treatment of immune-mediated diseases that are designed to return homeostasis and restore normal functioning neural-immune networks.

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Section: Sympathetic Neurotransmission In the Thymusmentioning

confidence: 78%

Section: T Lymphocytesmentioning

confidence: 99%

Section: T Lymphocytesmentioning

confidence: 99%

Section: B Lymphocytesmentioning

confidence: 99%

See 2 more Smart Citations

Sympathetic modulation of immunity: Relevance to disease

Bellinger

Millar

Perez

et al. 2008

Cellular Immunology

227

185

View full text Add to dashboard Cite

show abstract

“…It has been documented that numerous (Fuchs, Albright, & Albright, 1988). This evidence highlights the readiness of the immune system to interact and respond to neurotransmitters produced by the SNS (Kusnecov & Rabin, 1994).…”

Section: List Of Tablesmentioning

confidence: 84%

Psychological Hardiness and Biochemical Markers of Acute Stress

McCoy¹

2003

PsycEXTRA Dataset

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The establishment of physiological norms for psychologically hardy vs. nonhardy individuals was attempted by examination of levels of salivary cortisol and urinary norepinephrine before and after a mid-term examination stressor.Normative data was collected on the reported frequency of stressors and their severity one week prior to the examination, and self-reported ratings of stress immediately prior to the examination. Performance on the examination as a function of hardiness was explored. Associations between demographic variables and psychological hardiness were also studied. Results from this study were inconclusive in establishing physiological norms for psychologically hardy individuals. Associations were found between: 1) hardiness and frequency of stressors; 2) hardiness and age; and 3) self-reported ratings of stress and anxiety as measured by the State-Trait Anxiety Inventory (STAI).ii ACKNOWLEDGEMENTS With thanks and praise to God, who is the source of all wisdom; to Mike, for his constant love and support, and for helping to make this dream a reality; to Fr. Juan, who epitomizes hardiness, for assistance with graphics and for spiritual guidance during the rough spots; to Fr. Ken, for encouraging me to take this step and for spiritual direction through all the trials in my life; to Ernest Harrell, Mike Richmond, the Welch Foundation, and the Department of Psychology for funding my research; to Aunt Charlotte and Uncle Tony, for their emotional and financial support; to Scott for assistance in data collection and for being the best friend and colleague anyone could hope for; to Paul Lambert and Patti Price for allowing me to collect data in their classes; to Clarice and Shannon for all the laughter and for keeping me grounded; to

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Effect of adrenaline on lymphocyte metabolism and function. A mechanism involving cAMP and hydrogen peroxide

Rosa

1997

Cell Biochem. Funct.

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This study examined the effect of adrenaline on lymphocyte metabolism and function. The following parameters were addressed: cell proliferation, glucose and glutamine metabolism as indicated by the measurement of enzyme activities, the utilization of metabolites and production and oxidation of substrates. We also evaluated the involvement of beta-receptors in this response as well as the possible effect of cAMP and hydrogen peroxide in the process of lymphocyte activation by adrenaline. The results indicated that adrenaline is able to induce metabolic changes in lymphocytes that are related to enhanced proliferative capacity, but under physiological conditions fails to initiate the process, the catecholamine could, increase cell proliferation via increased production of H2O2 by macrophages, since this reactive oxygen intermediate can act as a trigger for lymphocyte activation. The results also showed that distinct populations of lymphocytes present different responses to adrenaline activation, as demonstrated by cells obtained from the same site but exposed to different mitogens such as LPS and ConA.

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β-Adrenergic receptors on murine lymphocytes: Density varies with cell maturity and lymphocyte subtype and is decreased after antigen administration

Cited by 106 publications

References 25 publications

Sympathetic modulation of immunity: Relevance to disease

Sympathetic modulation of immunity: Relevance to disease

Psychological Hardiness and Biochemical Markers of Acute Stress

Effect of adrenaline on lymphocyte metabolism and function. A mechanism involving cAMP and hydrogen peroxide

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