β-adrenoceptor agonists downregulate adiponectin, but upregulate adiponectin receptor 2 and tumor necrosis factor-α expression in adipocytes

Fu, Ling; Isobe, Kazumasa; Zeng, Qin; Suzukawa, Kazumi; Takekoshi, Kazuhiro; Kawakami, Yasushi

doi:10.1016/j.ejphar.2007.05.005

Cited by 63 publications

(43 citation statements)

References 43 publications

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“…In addition, a negative correlation between p-NE and insulin sensitivity (measured as QUICKI) was found in the present study. This is consistent with results of previous studies, one of which found that catecholamines stimulate adipocyte secretion of tumor necrosis factor-α (TNF-α) (Fu et al, 2007). By directly inhibiting the actions of insulin, TNF-α may contribute to the pathogenesis of catecholamine induced decreased insulin sensitivity (Borst, 2004).…”

Section: Discussionsupporting

confidence: 82%

The association between norepinephrine and metabolism in patients with major depression

Futtrup

Nordentoft²,

Elfving

et al. 2018

Neurology, Psychiatry and Brain Research

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Background: Previous studies indicate that levels of plasma norepinephrine (p-NE) are altered in depressed patients. However, it is unclear whether altered NE metabolism is involved in the pathogenic association between depression and cardiovascular disease. The aim of the present study was, firstly, to investigate if p-NE levels differ between patients with major depression and healthy controls. Secondly, the study sought to assess the associations between p-NE and metabolic variables in all participants. The third and final aim of the study was to assess if the associations between p-NE and metabolic variables are influenced by disease status (depression vs. healthy). Methods: 108 patients with major depression and 44 healthy controls were tested for levels of p-NE and metabolic variables that affect cardiovascular risk. Results: The median level of p-NE in depressed patients (DSM-IV) was 2636 pg/ml, (IQR 2094-3143) and 2279 pg/ml (IQR 2007-2562) in non-depressed controls (p = 0.013). However, the difference between p-NE levels was non-significant when adjusted for daily smoking (p = 0.138). Significant associations (p ≤ 0.05) were observed between p-NE and p-lipids, mean arterial blood pressure, p-insulin, quantitative insulin sensitivity check index as well as inflammatory markers. Conclusions: Elevated levels of p-NE observed in patients with major depression were attributable to daily smoking, rather than to the depressive disorder. Important associations were found between p-NE and metabolic variables that affect cardiovascular risk. This is interesting from a clinical point of view, since affected individuals may benefit from simple and inexpensive treatments that influence sympathetic activity. All associations were independent of disease status.

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Section: Discussionsupporting

confidence: 82%

The association between norepinephrine and metabolism in patients with major depression

Futtrup

Nordentoft²,

Elfving

et al. 2018

Neurology, Psychiatry and Brain Research

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“…In a previous study, we observed that -adrenergic agonists enhance adiponectin receptor 2 mRNA expression in mice and the 3T3-L1 cell line 6) . Pheochromocytoma is a catecholamine-producing tumor, and the incidence of impaired glucose tolerance in patients with pheochromocytoma has been reported to range from 25% to 75% 7,8) .…”

Section: Introductionmentioning

confidence: 86%

Adiponectin and Adiponectin Receptors in Human Pheochromocytoma

Isobe

Tatsuno

et al. 2009

JAT

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Aim: Recent studies have demonstrated that serum adiponectin and its receptors in adipose and muscle tissues are suppressed in diabetic or obese individuals. Patients with pheochromocytoma are frequently diabetic. Methods: Using real-time PCR, we examined mRNA expressions of adiponectin (Adp) and adiponectin receptor 1 (AdpR1) and AdpR2 in pheochromocytoma tissues from 49 patients. We also measured levels of serum total and high molecular weight (HMW) adiponectin levels in 10 pheochromocytomas and 33 normal volunteers.

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“…Much experimental evidence has demonstrated that adipose tissue is innervated by the sympathetic nervous system in rodents, which can regulate lipolysis, fat cell number, proliferation, and the secretion of some adipocytokines, such as TNF-␣ and MCP-1 (3,19,26). Furthermore, the activity of the sympathetic nervous system has been shown to be increased in obese individuals and proposed to contribute to insulin resistance through the various effects of catecholamines on adipocytes (38).…”

Section: Discussionmentioning

confidence: 99%

“…To examine the relationship between adipocytokines and poststroke hyperglycemia, we used a rat model with ischemic brain injury and examined the changes of several adipose tissue-derived cytokines, including TNF-␣, IL-1␤, IL-6, MCP-1, leptin, and adiponectin, after acute stroke. In addition, sympathetic tone has been shown to be activated by experimental cerebral ischemia (10,34), and several studies have reported that sympathetic nervous system regulates the expression of several adipocytokines through adipocyte ␤-adrenergic receptors (3,19,26). Therefore, this study also determined whether alterations in adipose proinflammatory cytokines following acute stroke, if any, were medicated by sympathetic system using a nonselective ␤-adrenergic receptor blocker, propranolol.…”

mentioning

confidence: 99%

Adipose proinflammatory cytokine expression through sympathetic system is associated with hyperglycemia and insulin resistance in a rat ischemic stroke model

Wang

Lin²,

Chuang³

et al. 2011

American Journal of Physiology-Endocrinology and Metabolism

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Wang YY, Lin SY, Chuang YH, Chen CJ, Tung KC, Sheu WH. Adipose proinflammatory cytokine expression through sympathetic system is associated with hyperglycemia and insulin resistance in a rat ischemic stroke model. Am J Physiol Endocrinol Metab 300: E155-E163, 2011. First published October 26, 2010 doi:10.1152/ajpendo.00301.2010Patients who experience acute ischemic stroke may develop hyperglycemia, even in the absence of diabetes, but the exact mechanisms are still unclear. Adipose tissue secretes numerous proinflammatory cytokines and is involved in the regulation of glucose metabolism. This study aimed to determine the effects of acute stroke on adipose inflammatory cytokine expression. In addition, because sympathetic activity is activated after acute stroke and catecholamines can regulate the expression of several adipocytokines, this study also evaluated whether alterations in adipose proinflammatory cytokines following acute stroke, if any, were medicated by sympathetic system. Acute ischemic brain injury was induced by ligating the right middle cerebral artery and bilateral common carotid arteries in male adult Sprague-Dawley rats. Adipose tumor necrosis factor-␣ (TNF-␣) and monocyte chemoattractant protein-1 (MCP-1) mRNA and protein levels were determined by RT-PCR and enzyme-linked immunoassay, respectively. The stroke rats developed glucose intolerance on days 1 and 2 after cerebral ischemic injury. The fasting blood insulin levels and insulin resistance index measured by homeostasis model assessment were higher in the stroke rats compared with the sham group. Epididymal adipose TNF-␣ and MCP-1 mRNA and protein levels were elevated one-to twofold, in association with increased macrophage infiltration into the adipose tissue. When the rats were treated with a nonselective ␤-adrenergic receptor blocker, propranolol, before induction of cerebral ischemic injury, the acute stroke-induced increase in TNF-␣ and MCP-1 was blocked, and fasting blood insulin concentration and homeostasis model assessment-insulin resistance were decreased. These results suggest a potential role of adipose proinflammatory cytokines induced by the sympathetic nervous system in the pathogenesis of glucose metabolic disorder in rats with acute ischemic stroke. monocyte chemoattractant protein-1; sympathetic nervous system; tumor necrosis factor-␣

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β-adrenoceptor agonists downregulate adiponectin, but upregulate adiponectin receptor 2 and tumor necrosis factor-α expression in adipocytes

Cited by 63 publications

References 43 publications

The association between norepinephrine and metabolism in patients with major depression

The association between norepinephrine and metabolism in patients with major depression

Adiponectin and Adiponectin Receptors in Human Pheochromocytoma

Adipose proinflammatory cytokine expression through sympathetic system is associated with hyperglycemia and insulin resistance in a rat ischemic stroke model

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