β-Carboline Alkaloids from <i>Stellaria dichotoma</i> var. <i>lanceolata</i> and Their Anti-inflammatory Activity

Chen, Yuh‐Fung; Kuo, Ping Chung; Chan, Hsiu-Hui; Kuo, I-Je; Lin, Fu‐Wen; Su, Chung‐Ren; Yang, Meilin; Li, Ding-Tzai; Wu, Tong

doi:10.1021/np1003627

Cited by 66 publications

(18 citation statements)

References 19 publications

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“…Ten compounds were putatively identified in the extract according to a previous report (Chen et al, 2010). We detected some β-carboline alkaloids, such as stellarine A–C, dichotomine B, H, and L, glucodichotomine B as well as vanillin, 5-hydroxymethylfurfural (Fig.…”

Section: Resultsmentioning

confidence: 99%

“…RS was first described in “Ben Cao Gang Mu” 400 years ago (Teng, 1985). According to the clinical studies, RS also has several other pharmacological functions, including anti-inflammatory (Chen et al, 2010), anti-cancer, and anti-allergic activities (Morikawa et al, 2004; Sun et al, 2004) as well as dilation of blood vessels (Morita et al, 2005). Recently, it has been reported that RS had a higher content of α-spinasterol, which has anti-inflammatory and antipyretic effect and β-carboline alkaloids in RSE with anti-allergy properties through the mice anti-allergic reaction experiment (Morikawa et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

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Radix Stellariae extract prevents high-fat-diet-induced obesity in C57BL/6 mice by accelerating energy metabolism

Liu

Fan

et al. 2017

PeerJ

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Stellaria dichotoma L. is widely distributed in Ningxia and surrounding areas in northwestern China. Its root, Radix Stellariae (RS), has been used in herbal formulae for treating asthenic-fever, infection, malaria, dyspepsia in children and several other symptoms. This study investigated whether the RS extract (RSE) alleviates metabolic disorders. The results indicated that RSE significantly inhibited body weight gain in high-fat (HF)-diet-fed C57BL/6 mice, reduced fasting glucose levels, and improved insulin tolerance. Moreover, RSE increased the body temperature of the mice and the expression of uncoupling proteins and peroxisome proliferator-activated receptors in the white adipose tissue. Thus, RSE alleviated metabolic disorders in HF-diet-fed C57BL/6 mice by potentially activating UCP and PPAR signaling.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Radix Stellariae extract prevents high-fat-diet-induced obesity in C57BL/6 mice by accelerating energy metabolism

Liu

Fan

et al. 2017

PeerJ

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“…-scavenging activity in concomitance with NO mitigation potential might makes both the alkaloids extracts of T. terrestris as superior antiinflammatory drug entities, as like β-carboline alkaloids from Stellaria dichotoma [22] . Although the functioning of NO in inflammation concerns are quite obscure [23] .…”

Section: Resultsmentioning

confidence: 99%

Reactive Species Metabolism and Cytotoxicity of Tribulus terrestris L. Alkaloid Extracts in Leukemic Cell Line

Basaiyye¹,

Bafana²,

Naoghare³

et al. 2018

pharmaceutical-sciences

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Basaiyye et al.: Cytotoxic Nature of Antioxidant Alkaloid Extracts of Tribulus terrestris L. FruitsThe present communication dealt with cytotoxic and free radical scavenging potential of tertiary and quaternary alkaloid extracts of Tribulus terrestris fruits. Tertiary and quaternary alkaloid extracts were found to be cytotoxic to leukemic cells (Jurkat E6-1) with LC 50 values of 100 and 42 µg/ml, respectively. Compared to the control, reactive oxygen species and reactive nitrogen species were significantly reduced in the cells treated with lower concentrations of tertiary and quaternary alkaloid extracts. Cells treated with tertiary alkaloid extract demonstrated significantly elevated levels of peroxidise, catalase and superoxide dismutaselike activities, whereas cells treated with quaternary alkaloid extracts showed insignificant elevations of the tested enzyme activities, compared to the control cells. The antioxidant activity of tertiary alkaloid (100 µg/ml) extract was 46.78 and 14.92 µg/ml of ascorbic acid equivalent as estimated in ferric reducing antioxidant potential and total antioxidant assays. Quaternary alkaloid extract displayed an IC 50 value of 159 µg/ml in the nitric oxide mitigation assay. Cells treated with quaternary alkaloid extracts showed 1.4-fold increase in superoxide dismutase-like activity compared to the control cells. These results suggest that tertiary and quaternary alkaloid extracts possessed cytotoxic and free radical scavenging potential against leukemic cells.

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“…All compounds tested exhibited signifi cant inhibition of NO production, with IC50 values in the range of 11.3-19.3 μM. [12] Flavonoids 1. Jaceosidin [ Figure 2a]: It is a fl avonoid isolated from several plants of the Compositae family.…”

Section: Introductionmentioning

confidence: 99%

Phytoconstituents responsible for anti-inflammatory activity

Sundriyal¹,

Mukhija²

2013

J Nat Pharm

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Infl ammation is the response of an organism's immune system to the damage caused to its cells and vascularized tissues by microbial pathogens such as viruses and bacteria, as well as by injurious chemicals or physical insults. Although painful, infl ammation is usually a healing response, but in some instances infl ammation proceeds to a chronic state, associated with debilitating diseases such as arthritis, multiple sclerosis, or even cancer. Although several anti-infl ammatory drugs are available, the treatment of infl ammation is still far from adequate. The current therapy of infl ammation with modern anti-infl ammatory drugs is associated with side effects and drug interactions. Several plants used for the treatment of infl ammation in different systems of traditional medicine have shown anti-infl ammatory activity in experimental animal models and many such plants claimed in the traditional system still remain to be scientifi cally investigated. In this review, we have compiled the newer reported herbal anti-infl ammatory constituents with their research advancements.

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β-Carboline Alkaloids from Stellaria dichotoma var. lanceolata and Their Anti-inflammatory Activity

Cited by 66 publications

References 19 publications

Radix Stellariae extract prevents high-fat-diet-induced obesity in C57BL/6 mice by accelerating energy metabolism

Radix Stellariae extract prevents high-fat-diet-induced obesity in C57BL/6 mice by accelerating energy metabolism

Reactive Species Metabolism and Cytotoxicity of Tribulus terrestris L. Alkaloid Extracts in Leukemic Cell Line

Phytoconstituents responsible for anti-inflammatory activity

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