β-carotene improves oocyte development and maturation under oxidative stress in vitro

Yu, Shuai; Zhao, Yong; Feng, Yanni; Zhang, Hongfu; Li, Lan; Shen, Wei; Zhao, Minghui; Liu, Min

doi:10.1007/s11626-019-00373-0

Cited by 21 publications

(20 citation statements)

References 51 publications

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“…Melatonin is a pineal secretory product regulating circadian rhythms [ 87 ]. Several studies have documented its capacity in scavenging ROS [ 88 ], also within ovarian follicles [ 88 ].…”

Section: Agents Consideredmentioning

confidence: 99%

Effects of Supplementation with Natural Antioxidants on Oocytes and Preimplantation Embryos

Budani

Tiboni

2020

Antioxidants

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For most infertile couples, in vitro fertilization (IVF) represents the only chance to conceive. Given the limited success of IVF procedures, novel approaches are continuously tested with the aim of improving IVF outcomes. Growing attention is devoted today to the potential benefit of natural antioxidants in the optimization of infertility treatments. This review summarizes current data in this context, focusing on both experimental studies on oocytes/embryos and clinical trials on antioxidants supplementation. Based on information gained from experimental studies, antioxidant supplementation may have beneficial effects on IVF outcomes in terms of quality and cryotolerance of in vitro produced embryos, together with positive effects on in vitro maturation oocytes and on early embryonic development. Unfortunately, from the clinical side, there is a paucity of evidence favoring the protective qualities of antioxidants. Among the antioxidants considered, coenzyme Q10 may be regarded as one of the most promising for its positive role in rescuing the oxidative stress-induced damages, but further data are needed. It is concluded that further trials are necessary to characterize the potential clinical value of antioxidants in IVF treatments.

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“…Melatonin is a pineal secretory product regulating circadian rhythms [ 87 ]. Several studies have documented its capacity in scavenging ROS [ 88 ], also within ovarian follicles [ 88 ].…”

Section: Agents Consideredmentioning

confidence: 99%

Effects of Supplementation with Natural Antioxidants on Oocytes and Preimplantation Embryos

Budani

Tiboni

2020

Antioxidants

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“…To explore the deep mechanisms of β-carotene improving spermatogenesis, the anti-oxidant enzymes and glutathione (GSH) level in testes were determined. We and other groups have found that β-carotene can increase the anti-oxidant capability to benefit the function of the biological systems ( Yu et al, 2019 ). GSH is an important antioxidant molecule.…”

Section: Resultsmentioning

confidence: 99%

“…Short-term dietary β-carotene supplement ameliorates ovarian steroidogenesis with the increase in the production of progesterone ( Arellano-Rodriguez et al, 2009 ), and benefits serum insulin concentrations in goats ( Meza-Herrera et al, 2013 ). We found that β-carotene acts as a potential antioxidant in the oocyte to improve its quality ( Yu et al, 2019 ). Moreover, β-carotene has been found to act as a valuable protective agent to improve heat stress or titanium oxide nanoparticle induced spermatogenic disorders due to its potent antioxidative effects ( Orazizadeh et al, 2014 ; Lin et al, 2016 ).…”

Section: Introductionmentioning

confidence: 99%

β-carotene Rescues Busulfan Disrupted Spermatogenesis Through Elevation in Testicular Antioxidant Capability

Han

Ming-ji

et al. 2021

Front. Pharmacol.

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β-carotene, precursor of vitamin A, is an excellent antioxidant with many beneficial properties. It is a lipid-soluble antioxidant and a very effective quencher of reactive oxygen species (ROS) to reduce the oxidative stress. In contrast to vitamin A, β-carotene is not toxic even consumed in higher amount when it is delivered from natural plant products. Recently, we found that β-carotene acts as a potential antioxidant in the oocyte to improve its quality. Even though many studies have been reported that β-carotene has the beneficial contribution to the ovarian development and steroidogenesis, it is unknown the effects of β-carotene on the spermatogenesis. This investigation aimed to explore the hypothesis that β-carotene could improve spermatogenesis and the underlying mechanism. And we found that β-carotene rescued busulfan disrupted spermatogenesis in mouse with the increase in the sperm concentration and motility. β-carotene improved the expression of genes/proteins important for spermatogenesis, such as VASA, DAZL, SYCP3, PGK2. Moreover, β-carotene elevated the testicular antioxidant capability by the elevation of the antioxidant glutathione and antioxidant enzymes SOD, GPX1, catalase levels. In conclusion, β-carotene may be applied for the infertile couples by the improvement of spermatogenesis, since, worldly many couples are infertile due to the idiopathic failed gametogenesis (spermatogenesis).

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“…Such a physiological-chronological scenario highlights the key role of BETA not only as a very effective quencher of ROS, but also as an important molecule which enhances both ovarian development and steroidogenesis. In an elegant study, the possible effect of BETA on oocyte maturation under oxidative stress and the involved underlying mechanisms was explored [46]; while ROS inhibited oocyte development/maturation and parthenogenetic activation, BETA actions vanished such deleterious mechanisms, enhancing ovarian activation and development. Additionally, the protective BETA effects against the oxidative damage in ovarian tissue facing ischemia throughout different expression patterns of the antioxidant enzymes superoxidase dismutase (SOD) and glutathione (GSH), plus the malondialdehyde (MDA) level, which is the end result of lipid peroxidation, have been proposed [47].…”

Section: Discussionmentioning

confidence: 99%

Precision Betacarotene Supplementation Enhanced Ovarian Function and the LH Release Pattern in Yearling Crossbred Anestrous Goats

Lopez-Flores

Meza-Herrera

Marı́n

et al. 2020

Animals

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The possible out-of-season effect of beta-carotene supplementation on ovulation rate (OR), antral follicles (AFN), and total ovarian activity (TOA = OR + AFN) as related to the LH release pattern in yearling anestrous goats was evaluated. In late April, Alpine-Saanen-Nubian x Criollo goats (n = 22, 26 N) were randomly allotted to: (1) Beta-carotene (BETA; n = 10, orally supplemented with 50 mg/goat/d; 36.4 ± 1.07 kg live weight (LW), 3.5 ± 0.20 units, body condition score (BCS) or (2) Non-supplemented (CONT; n = 12, 35.2 ± 1.07 kg LW, 3.4 ± 0.2 units BCS). Upon estrus synchronization, an intensive blood sampling (6 h × 15 min) was accomplished in May for LH quantifications; response variables included (pulsatility-PULSE, time to first pulse-TTFP, amplitude-AMPL, nadir-NAD and area under the curve-AUC). Thereafter, an ultrasonography scanning was completed to assess OR and AFN. The Munro algorithm was used to quantify LH pulsatility; if significant effects of time, treatment or interaction were identified, data were compared across time. Neither LW nor BCS (p > 0.05) or even the LH (p > 0.05); PULSE (4.1 ± 0.9 pulses/6 h), NAD (0.47 ± 0.13 ng) and AUC (51.7 ± 18.6 units) differed between treatments. Nonetheless, OR (1.57 vs. 0.87 ± 0.18 units) and TOA (3.44 vs. 1.87 ± 0.45 units) escorted by a reduced TTFP (33 vs. 126 ± 31.9 min) and an increased AMPL (0.55 vs. 0.24 ± 0.9 ng), favored to the BETA supplemented group (p < 0.05), possibly through a GnRH-LH enhanced pathway and(or) a direct effect at ovarian level. Results are relevant to speed-up the out-of-season reproductive outcomes in goats while may embrace translational applications.

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β-carotene improves oocyte development and maturation under oxidative stress in vitro

Cited by 21 publications

References 51 publications

Effects of Supplementation with Natural Antioxidants on Oocytes and Preimplantation Embryos

Effects of Supplementation with Natural Antioxidants on Oocytes and Preimplantation Embryos

β-carotene Rescues Busulfan Disrupted Spermatogenesis Through Elevation in Testicular Antioxidant Capability

Precision Betacarotene Supplementation Enhanced Ovarian Function and the LH Release Pattern in Yearling Crossbred Anestrous Goats

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