β-carotene Rescues Busulfan Disrupted Spermatogenesis Through Elevation in Testicular Antioxidant Capability

Ma, Dongxue; Han, Pengfei; Ming-ji, Song; Zhang, Hongfu; Shen, Wei; Huang, Guian; Zhao, Minghui; Sun, Qing‐Yuan; Zhao, Yong; Liu, Min

doi:10.3389/fphar.2021.593953

Cited by 9 publications

(7 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has been reported that olive leaf extract, Korean red ginseng, and Genistein can improve spermatogenesis (Chi et al, 2013;Jung et al, 2015;Ganjalikhan Hakemi et al, 2019). Furthermore, we found that alginate oligosaccharides, beta-carotene, and chestnut polysaccharides improved spermatogenesis at various levels (Yu et al, 2020;Zhao et al, 2020;Ma et al, 2021).…”

Section: Introductionmentioning

confidence: 84%

Taxifolin increased semen quality of Duroc boars by improving gut microbes and blood metabolites

et al. 2022

View full text Add to dashboard Cite

Taxifolin (TAX), as a natural flavonoid, has been widely focused on due to its strong anti-oxidation, anti-inflammation, anti-virus, and even anti-tumor activity. However, the effect of TAX on semen quality was unknown. The purpose of this study was to analyze the beneficial influences of adding feed additive TAX to boar semen in terms of its quality and potential mechanisms. We discovered that TAX increased sperm motility significantly in Duroc boars by the elevation of the protein levels such as ZAG, PKA, CatSper, and p-ERK for sperm quality. TAX increased the blood concentration of testosterone derivatives, antioxidants such as melatonin and betaine, unsaturated fatty acids such as DHA, and beneficial amino acids such as proline. Conversely, TAX decreased 10 different kinds of bile acids in the plasma. Moreover, TAX increased “beneficial” microbes such as Intestinimonas, Coprococcus, Butyrivibrio, and Clostridium_XlVa at the Genus level. However, TAX reduced the “harmful” intestinal bacteria such as Prevotella, Howardella, Mogibacterium, and Enterococcus. There was a very close correlation between fecal microbes, plasma metabolites, and semen parameters by the spearman correlation analysis. Therefore, the data suggest that TAX increases the semen quality of Duroc boars by benefiting the gut microbes and blood metabolites. It is supposed that TAX could be used as a kind of feed additive to increase the semen quality of boars to enhance production performance.

show abstract

Section: Introductionmentioning

confidence: 84%

Taxifolin increased semen quality of Duroc boars by improving gut microbes and blood metabolites

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Beta-carotene and other carotenoids are commonly recognized as biological antioxidants. However, the effectiveness of beta-carotene and other carotenoids as antioxidants in disease prevention has been a subject of controversy in clinical studies ( 37 , 38 ).…”

Section: Discussionmentioning

confidence: 99%

The effect of antioxidant dietary supplements and diet-derived circulating antioxidants on vitiligo outcome: evidence from genetic association and comprehensive Mendelian randomization

Ni,

Zhang,

Sun

et al. 2024

Front. Nutr.

View full text Add to dashboard Cite

BackgroundPrevious studies have indicated that antioxidant diets may have a positive impact on vitiligo by interfering with oxidative stress mechanisms. However, there has been a lack of research utilizing the Mendelian randomization (MR) method to analyze the relationship between antioxidant diet intake and vitiligo.MethodsIn this study, we employed both univariate Mendelian randomization (UVMR) and multivariate Mendelian randomization (MVMR) approaches. The specific antioxidant dietary supplements (such as coffee intake, green tea intake, herbal tea intake, standard tea intake, and average weekly red wine intake) as well as diet-derived circulating antioxidants, including Vit. C (ascorbate), Vit. E (α-tocopherol), Vit. E (γ-tocopherol), Carotene, Vit. A (retinol), Zinc, and Selenium (N = 2,603–428,860) were significantly associated with independent single-nucleotide polymorphisms (SNPs). We obtained pooled statistics on vitiligo from a meta-analysis of three genome-wide association studies (GWASs) of European ancestry, including 4,680 cases and 39,586 controls. Inverse variance weighted (IVW) was employed as the primary analytical method, and sensitivity analysis was conducted to assess the robustness of the main findings.ResultsGenetically, coffee intake [odds ratio (OR) = 0.17, 95% confidence interval (CI) 0.07–0.37, p = 1.57 × 10–5], average weekly red wine intake (OR = 0.28, 95% CI 0.08–1.00, p = 0.049), and standard tea intake (OR = 0.99, 95% CI 0.98–0.99, p = 5.66 × 10–7) were identified as protective factors against vitiligo. However, no causal effect between the intake of other antioxidant diets and vitiligo was found. Moreover, no instances of pleiotropy or heterogeneity were observed in this study.ConclusionOur study indicates that coffee, standard tea, and red wine consumption can potentially reduce the risk of vitiligo. However, there is insufficient evidence to support that other antioxidant diets have a significant effect on vitiligo.

show abstract

“…The balance of antioxidants and ROS is essential for many physiological processes including spermatogenesis and sperm maturation [ 44 , 45 ]. Studies have reported that GSH levels decline with aging and are accompanied by elevated oxidative stress in the heart, liver, kidneys, and brain [ 46 , 47 ].…”

Section: Discussionmentioning

confidence: 99%

Gss deficiency causes age-related fertility impairment via ROS-triggered ferroptosis in the testes of mice

Zhu,

Cheng,

Wang

et al. 2023

Cell Death Dis

View full text Add to dashboard Cite

Glutathione synthetase (GSS) catalyzes the final step in the synthesis of glutathione (GSH), a well-established antioxidant. Research on the specific roles of the Gss gene during spermatogenesis remains limited due to the intricate structure of testis. In this study, we identified pachytene spermatocytes as the primary site of GSS expression and generated a mouse model with postnatal deletion of Gss using Stra8-Cre (S8) to investigate the role of GSS in germ cells. The impact of Gss knockout on reducing male fertility is age-dependent and caused by ferroptosis in the testis. The 2-month-old S8/Gss−/− male mice exhibited normal fertility, due to a compensatory increase in GPX4, which prevented the accumulation of ROS. With aging, there was a decline in GPX4 and an increase in ALOX15 levels observed in 8-month-old S8/Gss−/− mice, resulting in the accumulation of ROS, lipid peroxidation, and ultimately testicular ferroptosis. We found that testicular ferroptosis did not affect spermatogonia, but caused meiosis disruption and acrosome heterotopia. Then the resulting aberrant sperm showed lower concentration and abnormal morphology, leading to reduced fertility. Furthermore, these injuries could be functionally rescued by inhibiting ferroptosis through intraperitoneal injection of GSH or Fer-1. In summary, Gss in germ cells play a crucial role in the resistance to oxidative stress injury in aged mice. Our findings deepen the understanding of ferroptosis during spermatogenesis and suggest that inhibiting ferroptosis may be a potential strategy for the treatment of male infertility.

show abstract

β-carotene Rescues Busulfan Disrupted Spermatogenesis Through Elevation in Testicular Antioxidant Capability

Cited by 9 publications

References 41 publications

Taxifolin increased semen quality of Duroc boars by improving gut microbes and blood metabolites

Taxifolin increased semen quality of Duroc boars by improving gut microbes and blood metabolites

The effect of antioxidant dietary supplements and diet-derived circulating antioxidants on vitiligo outcome: evidence from genetic association and comprehensive Mendelian randomization

Gss deficiency causes age-related fertility impairment via ROS-triggered ferroptosis in the testes of mice

Contact Info

Product

Resources

About