β-Caryophyllene suppresses ferroptosis induced by cerebral ischemia reperfusion via activation of the NRF2/HO-1 signaling pathway in MCAO/R rats

Hu, Qingwen; Zuo, Tianrui; Deng, Liangliang; Chen, Sha; Wu, Yu; Liu, Shengwei; Liu, JingDong; Wang, Xuan; Fan, Xiaomei; Dong, Zhi

doi:10.1016/j.phymed.2022.154112

Cited by 91 publications

(36 citation statements)

References 41 publications

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“…Metformin attenuates hyperlipidemia-associated vascular calcification through anti-ferroptotic effects [88]. β-Caryophyllene has significant neuroprotective effects in attenuating ischemic stroke injury, which is correlated with ferroptosis via the activation of the NRF2/HMXO1 axis [89]. Furthermore, baicalein and Xingnaojing injection reverse the injury of transient middle cerebral artery occlusion treatment via anti-ferroptosis, indicating ferroptosis is important in the development of cerebral I/R-induced injury [90, 91].…”

Section: Ferroptosis and Cvdmentioning

confidence: 99%

A Panoramic View of Ferroptosis in Cardiovascular Disease

Cheng¹,

Yu²,

Yang³

et al. 2023

Kidney Dis

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Background: Cardiovascular disease (CVD) remains the leading cause of disease burden worldwide. Ferroptosis, an iron-dependent form of programmed cell death, is characterized by the lethal accumulation of lipid peroxidation, which is morphologically, biochemically and genetically distinct from apoptosis, necrosis and pyroptosis. Emerging evidence provides exciting novel insights to allow for a deeper understanding of the physiology and pathology of ferroptosis in CVD. Summary: The rapidly evolving insights into ferroptosis have revealed its role in the pathogenesis of diverse forms of CVD, including cardiomyopathy, heart failure, atherosclerosis, pulmonary arterial hypertension and cerebrovascular disease. Various types of metabolic pathways are involved in the regulation of ferroptosis, including iron metabolism, lipid metabolism and oxidative metabolism. Modulators of ferroptosis, such as several clinical drugs, preclinical compounds and other emerging materials, have been applied as promising approaches in the prevention and treatment of CVD. Key message: In this review, we provide a 360-degree view of the latest progress in the field of ferroptosis in CVD, highlight the pathogenic role of ferroptosis in CVD and also discuss the importance and future directions of targeting ferroptosis in CVD.

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Section: Ferroptosis and Cvdmentioning

confidence: 99%

A Panoramic View of Ferroptosis in Cardiovascular Disease

Cheng¹,

Yu²,

Yang³

et al. 2023

Kidney Dis

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“…Study has proved that BCP can improve the neurological function score, infarct volume after CIRI. The mechanism is related to the activation of Nrf2/HO-1 axis [ 151 ].…”

Section: Activation Of Nrf2 Signaling Pathway In Cerebral Ischemic St...mentioning

confidence: 99%

“…Studies have shown that ferroptosis is involved in the process of injury induced by ischemia-reperfusion. The protective effect of BCP on ischemic brain injury is related to the regulation of ferroptosis, and its mechanism is related to the activation of the Nrf2/HO-1 pathway [ 151 ]. Another study showed that rehmannioside A can improve cognitive impairment after ischemic stroke, which may be related to inhibition of neuroptosis and activation of the PI3K/AKT/Nrf2 pathway [ 112 ].…”

Section: The Role and Mechanism Of Nrf2 In Cerebral Ischemic Strokementioning

confidence: 99%

Nrf2 Regulates Oxidative Stress and Its Role in Cerebral Ischemic Stroke

et al. 2022

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Cerebral ischemic stroke is characterized by acute ischemia in a certain part of the brain, which leads to brain cells necrosis, apoptosis, ferroptosis, pyroptosis, etc. At present, there are limited effective clinical treatments for cerebral ischemic stroke, and the recovery of cerebral blood circulation will lead to cerebral ischemia-reperfusion injury (CIRI). Cerebral ischemic stroke involves many pathological processes such as oxidative stress, inflammation, and mitochondrial dysfunction. Nuclear factor erythroid 2-related factor 2 (Nrf2), as one of the most critical antioxidant transcription factors in cells, can coordinate various cytoprotective factors to inhibit oxidative stress. Targeting Nrf2 is considered as a potential strategy to prevent and treat cerebral ischemia injury. During cerebral ischemia, Nrf2 participates in signaling pathways such as Keap1, PI3K/AKT, MAPK, NF-κB, and HO-1, and then alleviates cerebral ischemia injury or CIRI by inhibiting oxidative stress, anti-inflammation, maintaining mitochondrial homeostasis, protecting the blood–brain barrier, and inhibiting ferroptosis. In this review, we have discussed the structure of Nrf2, the mechanisms of Nrf2 in cerebral ischemic stroke, the related research on the treatment of cerebral ischemia through the Nrf2 signaling pathway in recent years, and expounded the important role and future potential of the Nrf2 pathway in cerebral ischemic stroke.

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“…Rehmannioside A remarkably increased SLC7A11 and GPX4 protein levels in H 2 O 2 -induced neuronal injury by promoting the PI3K/AKT/NRF2 pathway, attenuating ferroptosis, and improving cell survival [ 121 ]. β-Caryophyllene also remarkably enhances the nuclear translocation of NRF2 and promotes HO-1 and GPX4 expression to inhibit ferroptosis in cerebral IRI [ 122 ]. Kaempferol can also alleviate I/R-induced neuronal ferroptosis by promoting GPX4 and SLC7A11 expression in an NRF2-dependent manner [ 123 ].…”

Section: Mechanisms and Targeted Therapies For Ferroptosis In Irimentioning

confidence: 99%

Ferroptosis—A New Dawn in the Treatment of Organ Ischemia–Reperfusion Injury

Zhou

Han

Guo

et al. 2022

Cells

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Ischemia–reperfusion (I/R) is a common pathological phenomenon that occurs in numerous organs and diseases. It generally results from secondary damage caused by the recovery of blood flow and reoxygenation, followed by ischemia of organ tissues, which is often accompanied by severe cellular damage and death. Currently, effective treatments for I/R injury (IRI) are limited. Ferroptosis, a new type of regulated cell death (RCD), is characterized by iron overload and iron-dependent lipid peroxidation. Mounting evidence has indicated a close relationship between ferroptosis and IRI. Ferroptosis plays a significantly detrimental role in the progression of IRI, and targeting ferroptosis may be a promising approach for treatment of IRI. Considering the substantial progress made in the study of ferroptosis in IRI, in this review, we summarize the pathological mechanisms and therapeutic targets of ferroptosis in IRI.

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β-Caryophyllene suppresses ferroptosis induced by cerebral ischemia reperfusion via activation of the NRF2/HO-1 signaling pathway in MCAO/R rats

Cited by 91 publications

References 41 publications

A Panoramic View of Ferroptosis in Cardiovascular Disease

A Panoramic View of Ferroptosis in Cardiovascular Disease

Nrf2 Regulates Oxidative Stress and Its Role in Cerebral Ischemic Stroke

Ferroptosis—A New Dawn in the Treatment of Organ Ischemia–Reperfusion Injury

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