2012
DOI: 10.1136/annrheumdis-2011-200568
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β-catenin is a central mediator of pro-fibrotic Wnt signaling in systemic sclerosis

Abstract: Objectives Pathologic fibroblast activation drives fibrosis of the skin and internal organs in patients with systemic sclerosis (SSc). β-catenin is an integral part of adherens junctions and a central component of canonical Wnt signaling. Here, the authors addressed the role of β-catenin in fibroblasts for the development of SSc dermal fibrosis. Methods Nuclear accumulation of β-catenin in fibroblasts was assessed by triple staining for β-catenin, prolyl-4-hydroxylase-β and 4′,6-diamidino-2-phenylindole (DAP… Show more

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Cited by 186 publications
(181 citation statements)
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“…8 Similar results were also described in a mouse model characterized by conditional overexpression of a stabilized β-catenin-mutant selectively in fibroblasts of the murine ventral dermis by Hamburg and Atit. 27 In addition, Hamburg-Shields et al 28 recently published that the conditional overexpression of β-catenin in dermal fibroblasts is associated with the increased expression of extracellular matrix genes in vivo.…”
Section: Activation Of Canonical Wnt Signaling Induces Fibrosissupporting
confidence: 73%
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“…8 Similar results were also described in a mouse model characterized by conditional overexpression of a stabilized β-catenin-mutant selectively in fibroblasts of the murine ventral dermis by Hamburg and Atit. 27 In addition, Hamburg-Shields et al 28 recently published that the conditional overexpression of β-catenin in dermal fibroblasts is associated with the increased expression of extracellular matrix genes in vivo.…”
Section: Activation Of Canonical Wnt Signaling Induces Fibrosissupporting
confidence: 73%
“…7,20,24 The nuclear accumulation of β-catenin occurs in fibrotic skin from SSc patients compared with healthy controls. 7,8 Consistently, classical targets of canonical Wnt signaling are elevated in skin samples from SSc patients. 7,20 Similar results were also observed in other fibrotic tissues, such as non-alcoholic liver fibrosis and idiopathic pulmonary fibrosis.…”
Section: Activation Of Canonical Wnt Signaling In Fibrotic Diseasesmentioning
confidence: 75%
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