β‐Cyclodextrin‐Based Nanocomposite Derivatives: State of the Art in Synthesis, Characterization and Application in Molecular Recognition

Abstract

This review describes the synthesis of nanocomposite derivatives based on β‐cyclodextrin (β‐CD) using silver nanoparticles (NPs), gold NPs, magnetic NPs, carbon nanotubes, nanosheets, carbon dots and graphene oxide NPs. These nanocomposites were prepared by green synthesis method, chemical method, reduction method, thermal reduction, ultrasonication method and hydrothermal method. β‐CD is cyclic oligosaccharide consisting of seven glucose units linked by 1,4‐α‐glycosidic bonds. Its external surface is hydrophilic due to the substantial hydroxyl groups, and the interior is hydrophobic. β‐CD are useful in nanocomposites and metallic NPs because they provide nanoplatforms for biocompatibility. β‐CD is commonly used to change NPs because of their excellent biocompatibility, amphipathic properties and for enhancing the morphological and chemical features of nanocomposites. Thus, nanostructured materials based on β‐CD may enhance the potential for molecular recognition property which is a natural phenomenon and fundamentally important in chemistry and biology. The most important area in molecular recognition research is design and synthesis of model receptors (hosts) to recognize substrates (guests) of biochemical significance to mimic biological events. Because NPs have a high surface‐to‐volume ratio when combined with molecularly imprinted polymers (MIPs). This review briefs the application and characterizations of β‐CD based nanocomposites derivatives in molecular recognition.

Synthesis of cationic β-cyclodextrin functionalized silver nanoparticles and their drug-loading applications

“…CDs are extensively used in nanocomposites and metallic nanoparticles as they may influence the characteristics of nanoparticles, such as drug loading, solubility, stability, and bioavailability. 47 The C-β-CD has a characteristic structure and unique ability, which allows it to form inclusion complexation with drug molecules via the non-covalent interaction. Hence, CβCD-AgNPs were employed in loading thymol (THY), a natural phenolic compound with numerous biological activities, which could enhance the solubility and bioavailability of THY.…”

Comparison of the Conventional and Mechanochemical Syntheses of Cyclodextrin Derivatives

“…Although many CD-based nanoparticles contain both polymers and derivatized CDs, their preparation utilizes ultrasound, and in minority ball mills, they are dominantly not CD polymers [ 142 ]. There are two essential groups of CD-derived polymers.…”

Synthesis, Structural, Thermal Studies And Biological Activity Of Schiff Base Transition Metal Complexes

“…After refluxing the mixture for an hour and stirring it, the complexes precipitated. They were collected by filtration, and then cleaned many times using a 1:1 ethanol-water mixture and diethyl ether (11,12,(41)(42)(43)(44)(45).…”