β-Cyclodextrin-Bearing Gold Glyconanoparticles for the Development of Site Specific Drug Delivery Systems

Aykaç, Ahmet; Martos-Maldonado, Manuel C.; Casas‐Solvas, Juan M.; Quesada-Soriano, Indalecio; Garcı́a-Maroto, Federico; Garcı́a-Fuentes, Luis; Vargas‐Berenguel, Antonio

doi:10.1021/la403454p

Cited by 71 publications

(54 citation statements)

References 60 publications

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“…For instance, cyclodextrin-modified gold nanoparticles have been applied to construct versatile platform via host−guest interaction for targeted drug delivery conveniently. 31,32 Herein, a multifunctional nanocomposite based on β-cyclodextrin-modified gold nanoparticle (AuNP@CD) was delicately designed and fabricated for cancer-targeted therapy with intracellular pH-triggered drug delivery. As shown in Scheme 1, the peptidic derivative adamantane−PEG 8 −glycine− arginine−glycine−aspartic−serine (AD-PEG 8 -GRGDS) and the adamantane conjugated anticancer drug doxorubicin with hydrazone bond linkage (AD-Hyd-DOX) were decorated on the surface of AuNP@CD via host−guest interaction simultaneously, forming multifunctional nanocomposite AuNP@CD-AD-DOX/RGD.…”

Section: Introductionmentioning

confidence: 99%

Rational Design of Multifunctional Gold Nanoparticles via Host–Guest Interaction for Cancer-Targeted Therapy

Chen

Lei

Luo

et al. 2015

ACS Appl. Mater. Interfaces

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A versatile gold nanoparticle-based multifunctional nanocomposite AuNP@CD-AD-DOX/RGD was constructed flexibly via host-guest interaction for targeted cancer chemotherapy. The pH-sensitive anticancer prodrug AD-Hyd-DOX and the cancer-targeted peptide AD-PEG8-GRGDS were modified on the surface of AuNP@CD simultaneously, which endowed the resultant nanocomposite with the capability to selectively eliminate cancer cells. In vitro studies indicated that the AuNP@CD-AD-DOX/RGD nanocomposite was preferentially uptaken by cancer cells via receptor-mediated endocytosis. Subsequently, anticancer drug DOX was released rapidly upon the intracellular trigger of the acid microenvirenment of endo/lysosomes, inducing apoptosis in cancer cells. As the ideal drug nanocarrier, the multifunctional gold nanoparticles with the active targeting and controllable intracellular release ability hold the great potential in cancer therapy.

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Section: Introductionmentioning

confidence: 99%

Rational Design of Multifunctional Gold Nanoparticles via Host–Guest Interaction for Cancer-Targeted Therapy

Chen

Lei

Luo

et al. 2015

ACS Appl. Mater. Interfaces

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“…Compounds 2 [36], 3[31,32], 15 [36] and 16 [36] were synthesized as previously reported. Human galectin-3 was expressed and purified as previously reported [45].…”

Section: General Methodsmentioning

confidence: 99%

Multivalent Lactose–Ferrocene Conjugates Based on Poly(Amido Amine) Dendrimers and Gold Nanoparticles as Electrochemical Probes for Sensing Galectin-3

Martos-Maldonado

Quesada-Soriano

Garcı́a-Fuentes

et al. 2020

Preprint

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Galectin-3 is considered a cancer biomarker and bioindicator of fibrosis and cardiac remodeling, and, therefore, it is desirable to develop convenient methods for its detection. Herein, an approach based on the development of multivalent electrochemical probes with high galectin-3 sensing abilities is reported. The probes consist of multivalent presentations of lactose-ferrocene conjugates scaffolded on poly(amido amine) (PAMAM) dendrimers and gold nanoparticles. Such multivalent lactose-ferrocene conjugates are synthesized by coupling of azidomethylferrocene-lactose building blocks on alkyne-functionalized PAMAM, for the case of the glycodendrimers, and to disulfide-functionalized linkers that are then used for the surface modification of citrate-stabilized gold nanoparticles. The binding and sensing abilities towards galectin 3 of both ferrocene-containing lactose dendrimers and gold nanoparticles have been evaluated by means of isothermal titration calorimetry, UV-vis spectroscopy, and differential pulse voltammetry. The highest sensitivity by electrochemical methods to galectin-3 was shown by lactosylferrocenylated gold nanoparticles, which are able to detect the lectin in nanomolar concentrations.

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“…Despite the most common carriers are based on nano- and microparticles (i.e., albumin, poly(lactic- co -glycolic acid)-PLGA NPs, liposomes), many examples in literature report on the development of gold-based glyco nanoparticles as efficient system to delivery payloads. In this contest, AuNPs modified with lactose moieties and β-cyclodextrins have been reported by Vargas-Berenguel et al [87]. The authors showed that GAuNPs were still able to recognize specific lectin (peanut agglutinin, PNA) and human galectin-3 (Gal-3), exploiting multiple lactose residues displayed on gold surface.…”

Section: Reviewmentioning

confidence: 96%

Glyco-gold nanoparticles: synthesis and applications

Compostella¹,

Pitirollo²,

Silvestri³

et al. 2017

Beilstein J. Org. Chem.

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Glyco-gold nanoparticles combine in a single entity the peculiar properties of gold nanoparticles with the biological activity of carbohydrates. The result is an exciting nanosystem, able to mimic the natural multivalent presentation of saccharide moieties and to exploit the peculiar optical properties of the metallic core. In this review, we present recent advances on glyco-gold nanoparticle applications in different biological fields, highlighting the key parameters which inspire the glyco nanoparticle design.

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β-Cyclodextrin-Bearing Gold Glyconanoparticles for the Development of Site Specific Drug Delivery Systems

Cited by 71 publications

References 60 publications

Rational Design of Multifunctional Gold Nanoparticles via Host–Guest Interaction for Cancer-Targeted Therapy

Rational Design of Multifunctional Gold Nanoparticles via Host–Guest Interaction for Cancer-Targeted Therapy

Multivalent Lactose–Ferrocene Conjugates Based on Poly(Amido Amine) Dendrimers and Gold Nanoparticles as Electrochemical Probes for Sensing Galectin-3

Glyco-gold nanoparticles: synthesis and applications

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