β-Elemene Induces Apoptosis in Human Renal-cell Carcinoma 786-0 Cells through Inhibition of MAPK/ERK and PI3K/Akt/mTOR Signalling Pathways

β-elemene Induces Caspase-dependent Apoptosis in Human Glioma Cells in vitro through the Upregulation of Bax and Fas/FasL and Downregulation of Bcl-2

“…Researches have found that β-elemene showed strong antitumor activity in glioblastoma cell lines from the human and rat . β-elemene induced apoptosis in human renal-cell carcinoma cells by regulating MAPK/ERK and PI3K/Akt/ mTOR signaling pathways (Zhan et al, 2012). The result indicated a protective autophagy induced by β-elemene, and inhibition of autophagy might be an effective approach to enhance the anti-tumor effect of β-elemene.…”

Volatile constituents of Distichochlamys citrea M. F. Newman and Distichochlamys orlowii K. Larsen M. F. Newman (Zingiberaceae) from Vietnam

“…For example, 1,8-cineole was known to exhibited several biological activities such a antiinflammatory (Juergens, 2014) and allelopathic (Nishida et al, 2005). The antitumor activities of β-elemene (Zhan et al, 2012), β-caryophyllene (Legault and Pichette, 2007) and 1,8-cineole (Juergens et al, 2004) against human cell cancer lines have been reported. Geranly acetate ha possessed antinociceptive (Quintans-Júnior et al, 2013), antifungal and anti-inflammatory (Gonçalves et al, 2012) effects.…”

Autophagy in Kidney Health and Disease

“…However, studies have shown that induction of autophagy can promote either cell survival or death in RCC cells. Inhibition of mTOR pathway induced autophagy in several RCC cell lines (7,49,104,105), but autophagy inhibitor chloroquine promoted cell death by preventing autophagy and inducing RIP kinase-and ROSmediated necroptosis in RCC cell line (RCC4) and suppressed xenograft growth (7), whereas PI3K/mTOR inhibitor suppressed cell growth and induced apoptosis in RCC cells (786-0) and concomitantly activated autophagy that protected against apoptosis (49,104) (Fig. 7C).…”