β-estradiol 3-benzoate affects spermatogenesis in the adult mouse

Toyama, Yoshiro; Hosoi, Ikuyoshi; Ichikawa, S.; Maruoka, Masayuki; Yashiro, Eiko; Itô, Haruo; Yuasa, Shigeki

doi:10.1016/s0303-7207(01)00419-1

Cited by 40 publications

(28 citation statements)

References 46 publications

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“…Since appearance of multinucleated giant cells and exfoliation of spermatids observed in the present study have been repeatedly reported in various experimental studiesclomiphene-treated rats (Vitale et al, 1973), E2-treated mice (Ohta and Takasugi, 1974), testosterone-treated and hypophysectomized rats (Muffly et al, 1994), E2B-treated rats (Blanco-Rodriguez and Martinez-Garcia, 1996), E2B-treated mice (Toyama et al, 2001a), BPA-, E2-, or E2B-treated rats and mice (Toyama and Yuasa, 2004), GOPC (Golgi associated PDZ-and coiled-and coil motif-containing protein) -/-mice (Yao et al, 2002;Ito et al, 2004, in this isssue), CAF1 (Chromatin Assembly Factor 1) -/ -or Cnot -/ -mice (Nakamura et al, 2004), mgcl (mouse germ cell less) -/ -mice (Kimura et al, 2003;Maekawa et al, 2004, in this issue) these phenomena do not seem to be hormone-specific defects.…”

Section: Discussionsupporting

confidence: 81%

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Adverse effects of bisphenol A to spermiogenesis in mice and rats

Toyama

Suzuki-Toyota

Maekawa

et al. 2004

Archives of Histology and Cytology

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Section: Discussionsupporting

confidence: 81%

“…It is noteworthy that the adult administration of E2B caused similar affects on mice (Toyama et al, 2001a). The treated mice showed disrupted spermiogenesis, and the ectoplasmic specialization between the Sertoli cell and spermatids was also affected.…”

Section: Discussionmentioning

confidence: 84%

Adverse effects of bisphenol A to spermiogenesis in mice and rats

Toyama

Suzuki-Toyota

Maekawa

et al. 2004

Archives of Histology and Cytology

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“…Exposure to the synthetic hormone, 17β-estradiol (E2), has been shown to induce Leydig cell atrophy, seminiferous tubule degeneration, and decreased sperm production, resulting in decreased testis weight (Cook et al, 1998). Estrogens are closely related to testicular development, spermatogenesis control, and male fertility (Carreau et al, 2007;Sinkevicius et al, 2009;Toyama et al, 2001). Estrogens also suppress c-KIT (type III receptor tyrosine kinase) expression in seminiferous tubules of the testis and simultaneously decrease proliferation and increase apoptosis in germ cells.…”

Section: Discussionmentioning

confidence: 99%

Effects of Short-Term Treatment with Estrogen Receptor Agonist on Morphological Changes in Reproductive Organs of Adult Male Mice

Choi

Lee

et al. 2016

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Male reproductive organs are strongly affected by estrogen signaling mediated via the estrogen receptor. In this study, propyl pyrazole triol (PPT), an estrogen receptor alpha agonist, was subcutaneously injected in adult male mice every 2 days for a total duration of 8, 16, or 24 days. Histological changes in the reproductive organs, including the testes, efferent ductules, and epididymides, were observed. The weight of the reproductive organs decreased in the PPT group. In addition, the diameter of the seminiferous tubules decreased in the PPT group compared with the control group. The epithelial cell height decreased in the initial segment of the epididymis, whereas the luminal diameter increased in the efferent ductules of the PPT group. PPT induced irregular morphology of stereocilia in the luminal region of the initial segment. Therefore, PPT treatment at high concentrations had inhibitory effects in the reproductive organs of adult male mice. These findings suggest that short-term treatment with estrogen receptor agonist causes histological changes in the testes, efferent ductules, and epididymis, which are similar to those caused by estrogen receptor antagonist treatment. Therefore, the estrogen receptor may have functional roles in male reproductive organs, implying that treatment with an estrogen receptor agonist can affect male fertility.

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“…Weights of the efferent ductules and epididymis showed similar results as that of testis weight. Estrogen is correlated with spermatogenesis regulation, histopathology, and changes in reproductive organ weight or fertility (Cook et al, 1998;Toyama et al, 2001;Aleem et al, 2006;Carreau et al, 2007). It has been suggested that decreased testis weight by estrogen treatment is related with interstitial cell atrophy, seminiferous tubule degeneration, and reduced sperm number (Cook et al, 1998).…”

Section: Discussionmentioning

confidence: 99%

Effects of Alternate Treatment of Estrogen Receptor Antagonist and Agonist on Morphology of Male Reproductive Organs of Adult Mice

Choi¹,

Seong²,

Park³

et al. 2013

Applied Microscopy

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ICI 182,780 (ICI) is known as an estrogen receptor antagonist, whereas propyl pyrazole triol (PPT) is an estrogen receptor agonist. In this study, ICI or ICI added with PPT was injected into adult male mice. Body and reproductive organ weights were reduced in the ICI added with PPT group compared to the control group. Further, the ICI and ICI added with PPT groups both showed increases in luminal areas of the seminiferous tubules of the testis, whereas cell heights of efferent ductules and the initial segment of the epididymis were reduced. Sperm count in the caudal epididymis was reduced in the ICI and ICI added with PPT groups. These results show that reproductive tissues were more deeply affected in the ICI added with PPT group. We also demonstrated that treatment with ICI resulted in histological changes in the testis, efferent ductule, and epididymis. Further, alternate treatment with ICI and PPT induced abnormalities in reproductive organs. These results indicate that a high concentration of PPT together with ICI may cause histological abnormalities instead of histological restoration in reproductive organs.

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β-estradiol 3-benzoate affects spermatogenesis in the adult mouse

Cited by 40 publications

References 46 publications

Adverse effects of bisphenol A to spermiogenesis in mice and rats

Adverse effects of bisphenol A to spermiogenesis in mice and rats

Effects of Short-Term Treatment with Estrogen Receptor Agonist on Morphological Changes in Reproductive Organs of Adult Male Mice

Effects of Alternate Treatment of Estrogen Receptor Antagonist and Agonist on Morphology of Male Reproductive Organs of Adult Mice

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