β-Glucan attenuates inflammatory responses in oxidized LDL-induced THP-1 cells via the p38 MAPK pathway

Wang, S; Zhou, Haoming; Feng, Tianyu; Wu, Ruihan; Sun, Xiu‐Lan; Guan, Naifu; Qu, Lefeng; Gao, Zhiwei; Yan, Jun; Xu, N.; Zhao, Jingjing; Qi, Chunjian

doi:10.1016/j.numecd.2013.09.019

Cited by 33 publications

(19 citation statements)

References 26 publications

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“…Moreover, it decreases lipoprotein lipase activity and monomeric lipoprotein lipase levels in plasma, which contributes to increased macrophage uptake of lipids [ 11 ]. The latter result suggests that a regular intake of the pasta investigated in this study may have an anti-inflammatory effect, probably linked to the immunomodulatory effects of β-glucans [ 12 ].…”

Section: Resultsmentioning

confidence: 97%

β-glucans: ex vivo inflammatory and oxidative stress results after pasta intake

et al. 2016

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BackgroundIt is well known that Mediterranean Diet can positively influence the health of each individual, in particular it is know that fibers have an important role. However, in Mediterranean cities most people do not have a close adherence to Mediterranean diet. Thus, in our study, we considered fibers like β-glucans that have been added to pasta with a percentage of 6 %. Our study aimed to evaluate the capacity of β-glucans intake on oxidative stress and inflammation in a cohort of middle aged slightly overweight subjects.MethodsWe used a longitudinal study design. The study lasted 30 days during which time, each participant acted with no food restriction. Participants underwent morning fasting blood venous sample for blood chemistry and other biological parameters at the beginning of the study and after 30 days of pasta supplemented with 6 % of β-glucan intake 4 times a week. We performed anthropometric, biochemical, oxidative stress and cytokine analysis at the beginning and the end of study.ResultsAfter the 30 days of pasta intake we obtained a significant decrease of LDL-cholesterol, IL-6 and AGEs levels.ConclusionThe results confirmed a capacity of β-glucans intake to lower oxidative stress. Additional longitudinal observation on community-based cohorts are needed to confirm these data and investigate the biological mechanisms through which effects are induced, and to fully explore the therapeutic potential of β-glucans.

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Section: Resultsmentioning

confidence: 97%

β-glucans: ex vivo inflammatory and oxidative stress results after pasta intake

et al. 2016

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“…Counteracting these mechanisms could also be attractive strategies to reduce atherosclerosis. Lastly, in vitro work with macrophages has shown that a potent nutritional supplement, β-D-glucan, is able to inhibit oxLDL-induced proinflammatory effects through regulation of p38 MAPK phosphorylation [196].…”

Section: Novel Strategies Targeting Inflammation Before MImentioning

confidence: 99%

The Role of Inflammation in Myocardial Infarction

Daskalopoulos

Hermans

Delft

et al. 2015

Inflammation in Heart Failure

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“…Moreover, Du et al (2016) found that the anti-inflammatory activity of polysaccharide from S. commune was influenced by ultrasonic treatment. It has been proposed that the potent anti-inflammatory activity of polysaccharide, possibly due to the inhibition of pro-inflammatory cytokines or enhancing production of anti-inflammatory cytokines (Wang S. et al, 2014). The aim of current study was to characterize the S. commune exopolysaccharide by elemental analysis, high performance liquid chromatography (HPLC), gas chromatography (GC), methylation analysis, circular dichroism (CD) studies, Fourier transform infrared spectroscopy (FT-IR), nuclear magnetic resonance (NMR) spectra, scanning electron microscopy (SEM), and atomic force microscope (AFM).…”

Section: Introductionmentioning

confidence: 99%

Characterization and Anti-Inflammatory Potential of an Exopolysaccharide from Submerged Mycelial Culture of Schizophyllum commune

Yang

Bian

et al. 2017

Front. Pharmacol.

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Background and Purpose: Mushroom polysaccharides have attracted attention in food and pharmacology fields because of their many biological activities. The structure characterization and anti-inflammatory activity of exopolysaccharide from Schizophyllum commune were evaluated in present study.Methods: An exopolysaccharide from a submerged mycelial fermentation of S. commune was obtained using DEAE-52 cellulose and Sephadex G-150 chromatography. The molecular weight (MW), monosaccharide compositions, chemical compositions, methylation analysis, circular dichroism studies, Fourier transform infrared spectroscopy, nuclear magnetic resonance (NMR) spectra, scanning electron microscopy (SEM), and atomic force microscopy were investigated.Results: It was a homogeneous protein-bound heteropolysaccharide with MW of 2,900 kDa. The exopolysaccharide contained a β-(1→3) glycosidic backbone, (1→4)- and (1→6)- glycosidic side chain, and high amount of glucose. The anti-inflammatory activity of exopolysaccharide was assessed by inhibiting the production of nitric oxide (NO), inducible nitric oxide synthase (iNOS), and 5- lipoxygenase (5-LOX) from macrophages. This exopolysaccharide significantly (p < 0.05) inhibited lipopolysaccharides-induced iNOS expression levels in the cells in a dose-dependent manner.Conclusion: It indicated significant anti-inflammatory effects, which showed that exopolysaccharide might be exploited as an effective anti-inflammatory agent for application in NO-related disorders such as inflammation and cancer.

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β-Glucan attenuates inflammatory responses in oxidized LDL-induced THP-1 cells via the p38 MAPK pathway

Cited by 33 publications

References 26 publications

β-glucans: ex vivo inflammatory and oxidative stress results after pasta intake

β-glucans: ex vivo inflammatory and oxidative stress results after pasta intake

The Role of Inflammation in Myocardial Infarction

Characterization and Anti-Inflammatory Potential of an Exopolysaccharide from Submerged Mycelial Culture of Schizophyllum commune

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