β-TCP nanoparticles doped with antimicrobial agents as an orthodontic adhesive component

Almeida, Carianne Mendes de; Ribeiro, Juliana Silva; Meereis, Carine Taís Welter; Ogliari, Aline Oliveira; Noremberg, Bruno S.; Ogliari, Fabrício Aulo; Michelon, Douver; Lund, Rafael Guerra

doi:10.1016/j.ijadhadh.2021.102896

Cited by 4 publications

(3 citation statements)

References 40 publications

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“…Lund and coworkers investigated the antibacterial effect of ß-tricalcium phosphate nanoparticles doped with commercial QACs (benzalkonium chloride, chlorhexidine) in orthodontic adhesive bonding brackets. 138 The resulting material largely inhibited the growth of cariogenic biofilms. Jin and co-workers developed two types (sphere and wire) of antibiofilm mesoporous silica nanoparticles with chlorhexidine.…”

Section: ■ Qac-embedded Antibiofilm Compositesmentioning

confidence: 99%

“…This approach appears promising in view of the lower toxicity of the nanocomposite in the vesicular membrane compared with free nanoparticles. Lund and co-workers investigated the antibacterial effect of ß-tricalcium phosphate nanoparticles doped with commercial QACs (benzalkonium chloride, chlorhexidine) in orthodontic adhesive bonding brackets . The resulting material largely inhibited the growth of cariogenic biofilms.…”

Section: Qac-embedded Antibiofilm Compositesmentioning

confidence: 99%

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From Antibacterial to Antibiofilm Targeting: An Emerging Paradigm Shift in the Development of Quaternary Ammonium Compounds (QACs)

et al. 2023

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In a previous development stage, mostly individual antibacterial activity was a target in the optimization of biologically active compounds and antiseptic agents. Although this targeting is still valuable, a new trend has appeared since the discovery of superhigh resistance of bacterial cells upon their aggregation into groups. Indeed, it is now well established that the great majority of pathogenic germs are found in the environment as surface-associated microbial communities called biofilms. The protective properties of biofilms and microbial resistance, even to high concentrations of biocides, cause many chronic infections in medical settings and lead to serious economic losses in various areas. A paradigm shift from individual bacterial targeting to also affecting more complex cellular frameworks is taking place and involves multiple strategies for combating biofilms with compounds that are effective at different stages of microbiome formation. Quaternary ammonium compounds (QACs) play a key role in many of these treatments and prophylactic techniques on the basis of both the use of individual antibacterial agents and combination technologies. In this review, we summarize the literature data on the effectiveness of using commercially available and newly synthesized QACs, as well as synergistic treatment techniques based on them. As an important focus, techniques for developing and applying antimicrobial coatings that prevent the formation of biofilms on various surfaces over time are discussed. The information analyzed in this review will be useful to researchers and engineers working in many fields, including the development of a new generation of applied materials; understanding biofilm surface growth; and conducting research in medical, pharmaceutical, and materials sciences. Although regular studies of antibacterial activity are still widely conducted, a promising new trend is also to evaluate antibiofilm activity in a comprehensive study in order to meet the current requirements for the development of highly needed practical applications.

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Section: ■ Qac-embedded Antibiofilm Compositesmentioning

confidence: 99%

Section: Qac-embedded Antibiofilm Compositesmentioning

confidence: 99%

From Antibacterial to Antibiofilm Targeting: An Emerging Paradigm Shift in the Development of Quaternary Ammonium Compounds (QACs)

et al. 2023

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“…Neste sentido, o processo de dopagem pode melhorar as propriedades de manuseio, desempenho angiogênico e osteogênico, atividade antimicrobiana, entre outras propriedades. Dentre os íons mais utilizados como dopantes na estrutura cristalina do β-TCP, o estrôncio (Sr) desempenha um papel importante na formação e remodelação óssea, onde é utilizado para o tratamento de osteoporose, acelerando o processo de osteogênese e de mineralização (Schatkoski et al, 2021;Almeida et al, 2021).…”

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ANÁLISE DO USO DO ESTRÔNCIO (Sr) COMO ÍON DOPANTE NA SÍNTESE DO BETA FOSFATO TRICÁLCICO (β-TCP): UM ESTUDO PROSPECTIVO

Farias,

Sales,

Almeida

et al. 2023

Análise E Desenvolvimento De Materiais Cerâmicos: Novas Perspectivas

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Historicamente, os cerâmicos são uns dos materiais mais antigos do mundo, em virtude do seu emprego desde a pré-história. São compostos inorgânicos formados por elementos metálicos e não metálicos, ligados através de ligações iônicas e/ou covalentes.As propriedades destes materiais são determinadas pelo tipo de ligação atômica, seu caráter amorfo ou cristalino, bem como pelos métodos de seu processamento. São caracterizados por apresentar propriedades tais como: resistência a altas temperaturas e a corrosão, dureza, são isolantes térmicos e elétricos.Cerâmicas a base de argilas, como peças decorativas, louças de mesa e relacionadas com a construção civil (louças sanitárias, cimento, tijolos, revestimento de piso ou parede), são classificadas como cerâmicas tradicionais. São elaboradas a partir de materiais naturais (ou pouco beneficiadas), de pureza variável, e com pouca exigência de controle em seu processamento.As cerâmicas avançadas ou cerâmicas de Engenharia são produzidas a partir de matérias primas sintéticas (óxidos, nitretos, carbetos e outros) ou beneficiadas industrialmente, com alto grau de pureza, e processamento controlado rigosamente. Estas cerâmicas são utilizadas em aplicações tecnológicas, estando presentes nas indústrias de componentes eletrônicos, de comunicação, automotiva, naval, aeroespacial, biomédica, e em muitas outras áreas industriais.Tendo em vista a importância dos materiais cerâmicos ao promover um resultado significativo na sociedade, visto que estão presentes em diferentes aplicações indústrias, este livro apresenta diferentes pesquisas relacionadas a estudos originais e de revisões bibliográficas na abordagem dessa área da ciência e engenharia de materiais.

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Chlorhexidine-loaded bioactive glass for incorporation into adhesive systems: Mechanical properties, antibacterial activity, cell viability, and hydroxyapatite precipitation

Brito

Ferreira

Cardoso

et al. 2023

International Journal of Adhesion and Adhesives

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β-TCP nanoparticles doped with antimicrobial agents as an orthodontic adhesive component

Cited by 4 publications

References 40 publications

From Antibacterial to Antibiofilm Targeting: An Emerging Paradigm Shift in the Development of Quaternary Ammonium Compounds (QACs)

From Antibacterial to Antibiofilm Targeting: An Emerging Paradigm Shift in the Development of Quaternary Ammonium Compounds (QACs)

ANÁLISE DO USO DO ESTRÔNCIO (Sr) COMO ÍON DOPANTE NA SÍNTESE DO BETA FOSFATO TRICÁLCICO (β-TCP): UM ESTUDO PROSPECTIVO

Chlorhexidine-loaded bioactive glass for incorporation into adhesive systems: Mechanical properties, antibacterial activity, cell viability, and hydroxyapatite precipitation

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