β2 Microglobulin expression in keratoacanthomas and squamous cell carcinoma

Graham, Robert; Macfarlane, Alexander W.; Curley, R.K.; Nash, Jennifer

doi:10.1111/j.1365-2133.1987.tb04923.x

Cited by 13 publications

(2 citation statements)

References 12 publications

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“…The distribution of ß2-microglobulin does not differ between KAs and SCCs. 38 However, blood group antigens have been reported to be present in KAs but either absent or present in a patchy distribution in SCCs,39 similar to the focal expression of TGF-a seen herein.…”

Section: Resultssupporting

confidence: 52%

Transforming Growth Factor a Expression Helps to Distinguish Keratoacanthomas From Squamous Cell Carcinomas

Ho¹

1991

Arch Dermatol

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Keratoacanthomas may be difficult to distinguish histologically from squamous cell carcinomas. We studied 20 keratocanthomas and 22 squamous cell carcinomas immunohistochemically using an antibody directed against transforming growth factor alpha to determine if the pattern of transforming growth factor alpha expression would provide a useful method of differentiating these tumors. Ninety percent of the keratoacanthomas demonstrated a diffuse pattern within tumor lobules in which all but the most peripheral rim of cells were stained. A similar localization of transforming growth factor alpha was not identified in squamous cell carcinomas. In addition, 40% of the squamous cell carcinomas but none of the keratoacanthomas showed focal transforming growth factor alpha immunostaining. Our results suggest that transforming growth factor alpha expression may be a marker of epithelial differentiation and may help distinguish between these two tumors.

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Section: Resultssupporting

confidence: 52%

Transforming Growth Factor a Expression Helps to Distinguish Keratoacanthomas From Squamous Cell Carcinomas

Ho¹

1991

Arch Dermatol

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“…A variety of investigative methods has been used to sepatate IvA frotn SC^C with vatyitig sticcess. These have included electroti mictoscopy (35), peantit lectin bitiditig siles (36,37), blood group H(O) andgeii distribulion (36), inltaepithelial elastic fibei" concentralioti (38), itiltacyloplastnic glycogeti coticetittaticin (38), ttatisfbtniitig gtowth factor alpha expression (39), involuctin locaiizalion (40), lDela.j-mictoglobttliti expressioti (41), atid flow and image cytometiy (42)(43)(44)(45)(46).…”

Section: Discussionmentioning

confidence: 99%

Keratoacanthoma: A deficient squamous cell carcinoma? Study of bcl‐2 expression

et al. 1994

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Ten keratoacanthomas with both proliferative and regressive histologic features along with 10 well‐differentiated squamous cell carcinomas were examined using immunohistochemistry for the expression of bcl‐2, a protooncogene recently recognized to be involved in protecting cells from undergoing apoptosis. The squamous cell carcinomas had a modest but diffuse staining pattern, while the proliferative keratoacanthomas stained only at the basal cells and only rare cells stained positively in the regressive keratoacanthomas. The degree and pattern of staining suggest a loss of bcl‐2 expression with tumor maturity in keratoacanthoma and a possible role in their ultimate involution. Sleater JP, Beers BB, Stephens CA, Hendricks JB. Keratoacanthoma: A deficient squamous cell carcinoma? Study of bcl‐2 expression.

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