γ-Fe2O3@Poly(sucrose allyl ether) magnetic microspheres for tumor enhanced magnetic resonance imaging and high-efficiency cooperative magnetothermal therapy

Zhou, Yanfang; Chen, Piaoyi; Chen, Mianrong; Li, Jiesong; Li, Xufeng; Lin, Lingyin; Lun, Yingying; Li, Qiuxia; Xiao, Qinglin; Huang, Yugang; Wang, Xianshu; Zou, Hongzhi; Ye, Guodong

doi:10.1016/j.matdes.2022.111062

Cited by 3 publications

(2 citation statements)

References 36 publications

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“…Therefore, incorporating Fe 3 O 4 into microspheres endows them with a sensitive potential for in vivo heating. More importantly, our laboratory has discovered a photocatalytic polymerization process in recent years for allylic monomers that demonstrate satisfactory efficiency [35] and is successfully applied in the synthesis of microspheres [36][37][38]. Conclusively, the multifunctional lipiodol-doped Fe 3 O 4 @Polydiallylisophthalate microspheres (IFeD MS) were successfully synthesized in a one-step photocatalytic process.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of 3-in-1 multifunctional lipiodol-doped Fe₃O₄@Poly (diallyl isophthalate) microspheres for arterial embolization, chemotherapy, and imaging

Chen,

Xiao,

Guo

et al. 2024

Biomed. Mater.

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Transcatheter arterial embolization (TAE) plays a pivotal role in treating various diseases. However, the efficacy of embolization therapy in cancer treatment can be limited by several factors, such as inevitable incomplete or non-target embolization, and the tumor recurrence and metastasis caused by the hypoxic microenvironment. Moreover, it is essential to explore simpler, more economical, and efficient methods for microsphere synthesis. Herein, we achieved one-step photocatalytic synthesis of lipiodol-doped Fe3O4@Poly(diallyl iso-phthalate) multifunctional microspheres (IFeD MS) for arterial embolization, chemotherapy, and imaging. The prepared microspheres are in the shape of dried plums, with a particle size of 100-300 μm. Lipiodol demonstrates a certain degree of chemotherapeutic activity, and the incorporation of Fe3O4 enables the microspheres to exhibit magnetothermal response and magnetic resonance imaging capabilities. Furthermore, the radiopaque characteristics of both agents provide the microspheres with promising potential for computed tomography and digital radiography imaging. The renal embolization experiment in rabbits demonstrated that IFeD MS achieved significant embolization and chemotherapeutic effects. Biocompatibility experiments revealed that this embolic agent did not induce tissue damage or inflammation beyond the treatment area. Additionally, IFeD MS exhibited promising imaging potential. The results of this study imply that the developed multifunctional embolic agent IFeD MS may have significant potential in transforming tumors previously only suitable for palliative cares into resectable radical treatments.

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Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of 3-in-1 multifunctional lipiodol-doped Fe₃O₄@Poly (diallyl isophthalate) microspheres for arterial embolization, chemotherapy, and imaging

Chen,

Xiao,

Guo

et al. 2024

Biomed. Mater.

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“…Many studies on magnetic materials have been carried out , especially magnetic nanoparticles for applications such as Ferrofluids (Saputro et al, 2019;Afkhami & Renardy, 2017), humidity sensors (Khorsand et al, 2020), Magnetic Resonance Imaging (MRI) (Zhou et al, 2022) and many more. Some natural materials contain this magnetic material, such as iron sand.…”

Section: Introductionmentioning

confidence: 99%

Crystal Structure and Magnetic Susceptibility of Iron Sand From Pangeo Village, Morotai Jaya Subdistrict as The Cathode of Lithium-Ion Batteries

Achmad,

Taib,

Ningrum

2022

tjp

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Morotai Island has a wealth of iron sand which is a natural resource in Morotai Jaya District, Pangeo Village. The utilization of iron sand is still for local community building materials. The purpose of this study was to determine the structure and magnetic susceptibility of iron sand as a basic material for cathode materials in the manufacture of lithium-ion batteries (LIB). The research sample was taken randomly, then it was prepared in the laboratory to obtain dry-phase iron sand. After being tested using an XRD tool, namely samples A, E, and I, it was found that there was a lot of Fe3O4 contained in iron sand. The diffraction peaks indicate Fe3O4 material with an inverse spinel structure. Sample A is the most crystalline compared to sample I. Sample E has the lowest diffraction peak pattern due to the dominant mineral hematite (Fe2O3) 70.31%. The value of the BSM test obtained the greatest magnetic susceptibility of 82867.54x10 -8 m 3 /kg. The smallest is in sample J with a value of 13186.98 54x10 -8 m 3 /kg because during synthesis it is slightly attracted by magnets and the color is not too black which mixes a lot with other materials. In addition, this relationship is directly proportional to sample E which contains the magnetic material Fe2O3 of the characterization of 70.31. The range of magnetic susceptibility values in samples A to L is in the interval (46 -80,000) x 10 -8 m 3 /kg, and (20,000 -110,000) x 10 -8 m 3 /kg. Based on this interval, both magnetic and mass susceptibility of each iron sand sample contained ilmenite (FeTiO3) particles in the antiferromagnetic group and magnetite (Fe3O4) in the ferromagnetic group.

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Recent progress in γ-Fe2O3-based catalysts: An overview of the synthesis and applications in environmental remediation

Zhou,

Yang,

Gong

et al. 2023

Chemical Engineering Journal

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γ-Fe2O3@Poly(sucrose allyl ether) magnetic microspheres for tumor enhanced magnetic resonance imaging and high-efficiency cooperative magnetothermal therapy

Cited by 3 publications

References 36 publications

Synthesis and characterization of 3-in-1 multifunctional lipiodol-doped Fe₃O₄@Poly (diallyl isophthalate) microspheres for arterial embolization, chemotherapy, and imaging

Synthesis and characterization of 3-in-1 multifunctional lipiodol-doped Fe₃O₄@Poly (diallyl isophthalate) microspheres for arterial embolization, chemotherapy, and imaging

Crystal Structure and Magnetic Susceptibility of Iron Sand From Pangeo Village, Morotai Jaya Subdistrict as The Cathode of Lithium-Ion Batteries

Recent progress in γ-Fe2O3-based catalysts: An overview of the synthesis and applications in environmental remediation

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γ-Fe2O3@Poly(sucrose allyl ether) magnetic microspheres for tumor enhanced magnetic resonance imaging and high-efficiency cooperative magnetothermal therapy

Cited by 3 publications

References 36 publications

Synthesis and characterization of 3-in-1 multifunctional lipiodol-doped Fe3O4@Poly (diallyl isophthalate) microspheres for arterial embolization, chemotherapy, and imaging

Synthesis and characterization of 3-in-1 multifunctional lipiodol-doped Fe3O4@Poly (diallyl isophthalate) microspheres for arterial embolization, chemotherapy, and imaging

Crystal Structure and Magnetic Susceptibility of Iron Sand From Pangeo Village, Morotai Jaya Subdistrict as The Cathode of Lithium-Ion Batteries

Recent progress in γ-Fe2O3-based catalysts: An overview of the synthesis and applications in environmental remediation

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Synthesis and characterization of 3-in-1 multifunctional lipiodol-doped Fe₃O₄@Poly (diallyl isophthalate) microspheres for arterial embolization, chemotherapy, and imaging

Synthesis and characterization of 3-in-1 multifunctional lipiodol-doped Fe₃O₄@Poly (diallyl isophthalate) microspheres for arterial embolization, chemotherapy, and imaging