δ‐Catenin as a potential cancer biomarker

Lü, Qun; Lanford, George W.; Hong, Hao; Chen, Yanhua

doi:10.1111/pin.12156

Cited by 9 publications

(12 citation statements)

References 11 publications

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“…37 d-Catenin has been reported to be a potential biomarker and therapy target for various cancers. 15 We find it may be also a neo-TAA for HCC.…”

Section: Discussionmentioning

confidence: 71%

“…Moreover, as mentioned above, Ctnnd2 coded d-Catenin is a potential biomarker and therapy target for cancer. 15 We aimed to design peptide vaccines targeted d-Catenin for HCC therapy. Irradiation is a conventional method for whole tumor cell lysates vaccines, for irradiation treatment may induce the expression of TAAs.…”

Section: D-catenin May Be a Stress-induced Factor And Highly Conservementioning

confidence: 99%

“…d-Catenin, coded by the gene CTNND2, has been reported to be overexpressed in various types of cancers, prostate, breast, lung and ovarian cancer included. [15][16][17][18] It is a potential biomarker for cancer. CTNND2 is also overexpressed in HCC carcinoma tissues, compared with normal tissues.…”

Section: Introductionmentioning

confidence: 99%

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δ-Catenin peptide vaccines repress hepatocellular carcinoma growth via CD8⁺ T cell activation

et al. 2018

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As classical therapy method of advanced hepatocellular carcinoma (HCC) is not effective enough, HCC immunotherapy is a hot spot for research in recent years. Although in recent years, immune checkpoint inhibitors are focused in cancer therapy, vaccines and adoptive cell therapy (ACT), as traditional immunotherapy methods for HCC are still promising. We found that δ-Catenin might be a new tumor-associated antigen for HCC, for it could be upregulated as a stress associated protein under hypoxia and irradiation treatment. δ-Catenin peptide vaccines could inhibit the growth of subcutaneous hepatocellular tumors in vivo. According to our work, δ-Catenin peptide vaccines could stimulate the activation of cytotoxic T lymphocytes (CTLs) and enhance the infiltration of CD8+ T cells into tumors. Moreover, δ-Catenin peptide vaccines could enhance the secretion of IFN-γ and the killing of tumor cells by T cells. Mechanistically, δ-Catenin peptide vaccines, presented by antigen-presenting cells to T cells, could enhance the activation of T cells via MAPK/ERK signaling and the transcriptional factors Eomes and T-bet. Our research results indicate new potential peptide vaccines, which can be applied in clinical HCC therapy.

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“…37 d-Catenin has been reported to be a potential biomarker and therapy target for various cancers. 15 We find it may be also a neo-TAA for HCC.…”

Section: Discussionmentioning

confidence: 71%

Section: D-catenin May Be a Stress-induced Factor And Highly Conservementioning

confidence: 99%

See 1 more Smart Citation

δ-Catenin peptide vaccines repress hepatocellular carcinoma growth via CD8⁺ T cell activation

et al. 2018

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“…δ-Catenin coded by the gene CTNND2 is recognized to be primarily expressed in the brains of normal people (3,4). However, in recent years, various research has revealed that δ-catenin also can be a biomarker for cancers, since it has been found to be overexpressed in various types of cancers, including prostate, breast, lung and ovarian cancer (3,(5)(6)(7). δ-Catenin can be expressed as different variants in different type of cancers (3).…”

Section: Introductionmentioning

confidence: 99%

“…However, in recent years, various research has revealed that δ-catenin also can be a biomarker for cancers, since it has been found to be overexpressed in various types of cancers, including prostate, breast, lung and ovarian cancer (3,(5)(6)(7). δ-Catenin can be expressed as different variants in different type of cancers (3). In some cell lines of ovarian, breast and esophageal cancer, a full length δ-catenin transcript is overexpressed.…”

Section: Introductionmentioning

confidence: 99%

δ-Catenin promotes tumorigenesis and metastasis of lung adenocarcinoma

et al. 2017

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δ-Catenin coded by gene CTNND2 has been found to be overexpressed in various types of cancers, including prostate, breast, lung and ovarian cancers. However, the function of δ-catenin in lung carcinoma remains largely unknown. In the present study, we revealed that δ-catenin acts as an oncogene promoting the malignancy of lung adenocarcinoma. When δ-catenin proteins of Lewis lung cells were depleted by knocking out Ctnnd2 via CRISPR/Cas9 technology, the cells lost the tumorigenic and metastatic abilities in vivo. Consistently, overexpression of Ctnnd2 enhances the subcutaneous tumorigenesis and distant metastasis of Lewis lung cells in vivo. However, δ-catenin promotes cell proliferation and cell cycle progression of Lewis lung cells. Mechanistically, δ-catenin enhances G1-S phase transition in cooperation with canonical Wnt signaling in Lewis lung cells. Moreover, δ-catenin promotes oncosphere formation of lung adenocarcinoma cells and is associated with the expression of cancer stem cell markers, which indicates δ-catenin enhances colonization and invasion via cancer stem cell maintenance. Taken together, our data suggest that δ-catenin may serve an important role in the malignancy of lung adenocarcinoma through activating canonical Wnt signaling and cancer stem cell maintenance. Our research indicates that δ-catenin can be a new potential target for the treatment of lung adenocarcinoma.

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δ-Catenin promotes the malignant phenotype in breast cancer

Zhang

Wang

2014

Tumor Biol.

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δ-Catenin is a member of the p120 catenin family. Similar to p120ctn, δ-catenin contains nine central Armadillo repeats and binds to the juxtamembrane domain (JMD) of E-cadherin. We used immunohistochemistry to detect δ-catenin expression in breast carcinoma (128 cases), and δ-catenin mRNA and protein expression was detected by reverse transcription-polymerase chain reaction and Western blotting (45 cases). The effects of δ-catenin on the activity of small GTPases and the biological behavior of breast cancer cells were explored by pulldown, flow cytometry, methyl thiazolyl tetrazolium, and Matrigel invasion assays. The results showed that δ-catenin expression increased in breast cancer tissues and was associated with a higher degree of malignancy (invasive lobular breast cancer, high tumor-node-metastasis stage, lymph node metastasis, and C-erbB-2+) and poor prognosis. Postoperative survival was shorter in patients with δ-catenin-positive expression than in patients with negative expression. δ-Catenin may regulate Cdc42/Rac1 activity, promote proliferation and invasion of breast cancer cells, and alter cell cycle progression. We conclude that δ-catenin tends to overexpress in breast carcinoma and promotes the malignant phenotype.

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δ‐Catenin as a potential cancer biomarker

Cited by 9 publications

References 11 publications

δ-Catenin peptide vaccines repress hepatocellular carcinoma growth via CD8⁺ T cell activation

δ-Catenin peptide vaccines repress hepatocellular carcinoma growth via CD8⁺ T cell activation

δ-Catenin promotes tumorigenesis and metastasis of lung adenocarcinoma

δ-Catenin promotes the malignant phenotype in breast cancer

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δ‐Catenin as a potential cancer biomarker

Cited by 9 publications

References 11 publications

δ-Catenin peptide vaccines repress hepatocellular carcinoma growth via CD8+ T cell activation

δ-Catenin peptide vaccines repress hepatocellular carcinoma growth via CD8+ T cell activation

δ-Catenin promotes tumorigenesis and metastasis of lung adenocarcinoma

δ-Catenin promotes the malignant phenotype in breast cancer

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Product

Resources

About

δ-Catenin peptide vaccines repress hepatocellular carcinoma growth via CD8⁺ T cell activation

δ-Catenin peptide vaccines repress hepatocellular carcinoma growth via CD8⁺ T cell activation