Δ⁶-i-Cholestadiene

Abstract

The yield was 5.27 g.(33.4% of the theoretical) of crude 5-chloromercuri-2thiophenecarbinol. Repeated recrystallization from hot water produced, a white powder melting at 183-185°, with decomposition.

Catechol‐O‐methyltransferase‐Inhibiting Pyrocatechol Derivatives: Synthesis and Structure‐Activity Studies

“…The skeleton of ketones of types A' and A' may be obtained by addition of an appropriate metallated alkyl or aryl entity, respectively, to an appropriate aldehyde and subsequent A4; Scheme 4). The phenacyl bromide IVa [24] was nitrated, affording IVb. The latter was transformed into the CI -keto-ester IVc by reaction with SeO, in EtOH [25].…”

“…NaHCO, (1.5 I). Bromomethyl4-Hydroxy-3 [24] (1 12.5 g, 0.46 mol) in AcOH (560 nl) was added, at r.t. within !4 h, under stirring a soln. of fuming HNO, (96%; 38 g, 0.58 mol) in AcOH (50 ml).…”

Scalable C–H Oxidation with Copper: Synthesis of Polyoxypregnanes

“…20 At this juncture, the allylic cyclopropane, which remained chemically silent until this point, was cleanly dismantled using HBr to afford the homoallylic bromide. 21 Silver-assisted solvolysis followed by acid treatment produced the natural product pergularin 2 (60% over 3 operations). From this point, two additional natural polyoxypregnanes were accessed by sequential stereoselective reductions.…”

Compounds with Positive Inotropic Activity, III1):Synthesis of 4‐Aminoquinoline Derivatives as Potential Positive Inotropic Agents

“…1. for the amination of the 4-chloro-quinolines 8a, 9a, and 9d to form quinoline derivatives [16][17][18][19][20][21][22][23] A solution of 5 mmol of 8a, 9a, and 9d resp. and 50 mmol of the appropriate amine in 50 ml of EtOH was refluxed for 30 min.…”