η⁴‐Pyrone Iron(0)carbonyl Complexes as Effective CO‐Releasing Molecules (CO‐RMs).

Abstract

2006Medicinal chemistry V 1100 η 4 -Pyrone Iron(0)carbonyl Complexes as Effective CO-Releasing Molecules (CO-RMs). -In order to rationalize the CO-releasing activity of some pyrone Fe(0)carbonyl complexes, the new products (I) are synthesized. Their intrinsic stability seems to influence the extent and rate of CO release, a feature which is affected by the presence of a halogen substituent on the pyrone ring. The cell viability index demonstrates that active carbon monoxide-releasing molecules such as (Ib) and (Ic) are promising compounds with potential therapeutic applications. -(FAIRLAMB*, I. J. S.; DUHME-KLAIR, A.-K.; LYNAM, J. M.; MOULTON, B. E.; O'BRIEN, C. T.; SAWLE, P.; HAMMAD, J.; MOTTERLINI, R.; Bioorg. Med. Chem. Lett. 16 (2006) 4, 995-998; Dep. Chem., Univ. York, Heslington, York YO10 5DD, UK; Eng.) -H. Hoennerscheid

Carbon monoxide-releasing molecules (CO-RMs): vasodilatory, anti-ischaemic and anti-inflammatory activities

“…Nonetheless, the results on CO-RMs' biology and chemistry undoubtedly indicate that these compounds are good candidates for the implementation of CO-releasing drugs [5,57]. As more and diversified new CO-RMs are being developed [57][58][59], we envision that this class of agents will be transformed into pharmaceuticals for the treatment of vascular and inflammatory disease states.…”

Dicarbonyl-bis(cysteamine)iron(II): A light induced carbon monoxide releasing molecule based on iron (CORM-S1)

“…In already known iron-based CORMs with iron(0)-or iron(II)-centers the CO-releasing properties (such as half life time) are triggered by the ligands [16][17][18], which themselves, however, possess an unknown degradation metabolism. Light-induced CO liberation from iron complexes is only known for pentacarbonyl iron, which is water insoluble and highly toxic.…”

Tricarbonylmanganese(I) and –rhenium(I) Complexes of Imidazol‐Based Phosphane Ligands: Influence of the Substitution Pattern on the CO Release Properties

“…[7][8][9] Whereas Motterlini et al have pioneered the use of carbonylruthenium compounds, with tricarbonylchloro(glycinato)ruthenium(II) (CORM-3) as the CO-releasing molecule most commonly employed in biological studies at present, [10] more recently carbonyl(pyrone)iron and -molybdenum complexes (CORM-F7 and CORM-F10) have also received considerable attention. [11][12][13] Whereas in these complexes the CO release is usually triggered by ligand-substitution reactions in aqueous solution, an alternative approach has explored the light-induced liberation of carbon monoxide from darkstable carbonylmanganese complexes, like [Mn 2 (CO) 10 ] (CORM-2). [14] In particular, the tricarbonyl complex [(tpm)Mn (CO) 3 ]PF 6 was shown to release CO upon UV radiation and exhibit cytotoxic activity against cancer cells while being inactive even after prolonged exposure in the dark.…”