κ-Opioid modulation of vasopressin secretion in conscious rats

Wells, Timothy; Forsling, ML

doi:10.1677/joe.0.1290411

Cited by 25 publications

(18 citation statements)

References 20 publications

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“…In vivo evidence indicates that endogenous dynorphin plays a key role in regulating the excitability of neurons in the hypothalamus, which in turn control the release of neurohormones from the posterior pituitary (Wells and Forsling, 1991;Brown et al, 1998). Specifically, this work has focused on the magnocellular neurosecretory cells (MNCs) in the paraventricular (PVN) and supraoptic (SON) nuclei of the hypothalamus.…”

Section: Introductionmentioning

confidence: 99%

“…The MNCs make either oxytocin (OT) or vasopressin (VP), but it is these latter cells in particular that have one of the highest concentrations of somatodendritically stored dynorphin in the brain (Watson et al, 1982;Shuster et al, 2000). Blocking -opioid receptors in vivo dramatically increases the excitability of MNCs (Wells and Forsling, 1991;Brown et al, 1998), indicating an ongoing and important role for dynorphin in regulating the output of this network. Since spiking in MNCs in vivo, both tonically (Nissen et al, 1995) and in response to physiological stimuli , is dependent on excitatory, glutamatergic synaptic inputs, we hypothesized that the retrograde modulation of glutamate neurotransmission by dynorphin would be an efficient way for MNCs to control their own activity.…”

Section: Introductionmentioning

confidence: 99%

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Retrograde Opioid Signaling Regulates Glutamatergic Transmission in the Hypothalamus

Iremonger¹,

Bains²

2009

J. Neurosci.

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Opioid signaling in the CNS is critical for controlling cellular excitability, yet the conditions under which endogenous opioid peptides are released and the precise mechanisms by which they affect synaptic transmission remain poorly understood. The opioid peptide dynorphin is present in the soma and dendrites of vasopressin neurons in the hypothalamus and dynamically controls the excitability of these cells in vivo. Here, we show that dynorphin is released from dendritic vesicles in response to postsynaptic activity and acts in a retrograde manner to inhibit excitatory synaptic transmission. This inhibition, which requires the activation of -opioid receptors, results from a reduction in presynaptic release of glutamate vesicles. The opioid inhibition is downstream of Ca 2ϩ entry and is likely mediated by a direct modulation of presynaptic fusion machinery. These findings demonstrate that neurons may self-regulate their excitability through the dendritic release of opioids to inhibit excitatory synaptic transmission.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Retrograde Opioid Signaling Regulates Glutamatergic Transmission in the Hypothalamus

Iremonger¹,

Bains²

2009

J. Neurosci.

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“…Because olanzapine is a selective monoaminergic antagonist with high binding affinity to D 2 , serotonin, muscarine, histamine, and adrenergic receptors, it causes SIADH by its antagonism to D 2 receptors (7,8).…”

Section: Discussionmentioning

confidence: 99%

Syndrome of Inappropriate Secretion of Antidiuretic Hormone Due to Olanzapine Use

Kir¹,

Gozugul²,

Dusunur³

et al. 2017

JAREM

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Hyponatremia secondary to syndrome of inappropriate secretion of antidiuretic hormone (SIADH), which is characterized by the sustained release of antidiuretic hormone (ADH) from the posterior pituitary gland, is a less-known but life-threatening complication of treatment with antipsychotic medications. We report a patient who was using olanzapine due to the diagnosis of schizophrenia and presented with status epilepticus. The patient's medical history and biochemical blood and urine test results were suggestive of SIADH and revealed that hyponatremia was secondary to SIADH, induced by olanzapine use. The patient was treated succesfully with olanzapine discontinuation, fluid restriction, and hypertonic/normal saline infusion. The possible adverse effects of olanzapine on sodium-water balance should always be kept in mind while prescribing it, and we suggest that clinicians should closely monitor electrolytes, particularly sodium, in patients on atypical antipsychotic medications such as olanzapine.

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“…( Wells, 1987;Wells & Forsling, 1991) and the animals allowed to recover for at least 24 h. After a 7 min intravenous infusion of sterile isotonic saline (0'1 ml/min), to offset the reduction in hlood volume caused by blood sampling, a measurement of mean arterial pressure was made, and a 1 ml arterial blood sample collected (between 1000 and 1600 h). The samples were treated as above to determine PCV and plasma AVP concentration, but the red cells were resuspended in sterile saline and re-injected.…”

Section: Basal a Vp Secretionmentioning

confidence: 99%

“…and diazepam (2' 5 mg/kg, Lp.) anaesthesia (Wells & Forsling, 1991). After 3 days recovery vascular cannulae were implanted as described above, and following a further 24 h recovery, mean arterial pressure was measured and a 1 ml arterial blood sample collected 2 min after the ICV injection of 5 ILl 0,85 M NaCl, a procedure previously characterized (Wells et al , 1990).…”

Section: Stimulated a Vp Secretionmentioning

confidence: 99%

Inter-colony variation in fluid balance and its relationship to vasopressin secretion in male Sprague-Dawley rats

et al. 1993

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SummarySalt and water balance and vasopressin secretion were measured in three colonies of SpragueDawley rats. Although sodium and water retention were similar between the groups, there were marked differences in both the rate and diurnal pattern of intake and excretion. Animals housed under semi-barrier conditions showed a lower basal plasma vasopressin concentration but were more sensitive to physiological stimuli.However, since pathogenic status and environmental conditions cannot entirely explain these results, genetic variation is likely to be a contributory factor. Animal science depends to a large extent upon the comparison of data obtained by different research groups on the same strains of animals. The validity of quantitative comparisons may be questioned if inter-colony variations arise from different breeding and housing conditions, or the isolated genetic pools from which the animals were derived. Fluid balance is one parameter affected by such factors. In rats there are marked strain differences in drinking behaviour (Walsh, 1980; Fregly et 01., 1990) and food intake (Walsh, 1980; Rowland & Fregly, 1988) There is some evidence that in man the osmotic threshold for AVP release is affected by genetic or environmental factors (Schrier et 01., 1979). It is therefore conceivable that the differences in salt and water balance, seen between strains, may also occur between separate colonies of the same strain of rat. KeywordsHaving performed water and salt balance studies on Sprague-Dawley rats at 3 research institutions, we report a retrospective comparison of these parameters from the 3 colonies. Since the secretion of AVP is a major factor in the control of body fluid homeostasis, this comparison also includes data for basal and stimulated plasma AVP concentrations. In addition, there is some evidence for a diurnal variation in AVP secretion (Windle et al., 1992) and therefore the patterns of water and electrolyte turnover have been investigated during the light and dark phases. An attempt was made to interpret the findings in relation to the available information on the pathogenic status and the conditions under which the animals were housed. The first group (colony X) were bred and housed under semi-barrier conditions, as described by Lewin and Hansen (1986), the second (colony Y) under open conditions separated only from other species and the third (colony Z) were purchased from a commercial supplier and housed in isolation.

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κ-Opioid modulation of vasopressin secretion in conscious rats

Cited by 25 publications

References 20 publications

Retrograde Opioid Signaling Regulates Glutamatergic Transmission in the Hypothalamus

Retrograde Opioid Signaling Regulates Glutamatergic Transmission in the Hypothalamus

Syndrome of Inappropriate Secretion of Antidiuretic Hormone Due to Olanzapine Use

Inter-colony variation in fluid balance and its relationship to vasopressin secretion in male Sprague-Dawley rats

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