μ-MIP: Molecularly Imprinted Polymer-Modified Microelectrodes for the Ultrasensitive Quantification of GenX (HFPO-DA) in River Water

Glasscott, Matthew W.; Vannoy, Kathryn J.; Kazemi, Rezvan; Verber, Matthew D.; Dick, Jeffrey E.

doi:10.1021/acs.estlett.0c00341

Cited by 57 publications

(81 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A 20 nm MIP film was deposited on the surface of a gold microelectrode ( r = 6.25 µm) via electropolymerization with the aim of the ultrasensitive quantification of GenX. [ 157 ] Electropolymerization was performed via ten cycles of cyclic voltammetry in an acetate buffer solution of o ‐phenylenediamine and GenX. Since the MIP layer was very thin, the template molecules were removed by soaking the microelectrode in a H 2 O/MeOH mixture (50:50, v/v) for only 15 min.…”

Section: Green Strategies For Benign Mipsmentioning

confidence: 99%

Molecular Imprinting: Green Perspectives and Strategies

et al. 2021

View full text Add to dashboard Cite

Large quantities of organic solvents and reagents are usually required in the fabrication of these materials. Moreover, the use of excess reagents in solvent extraction, purification, filtration/ centrifugation, and cleaning processes is essential for adequate product purity. Because of the numerous practical applications of advanced materials, some are synthesized on a large scale and commercialized. [3] The excessive consumption of nonrenewable, hazardous chemicals is an unsustainable practice and a prominent criticism of these materials. Nonetheless, the use of advanced materials in sensing applications, medicine, electronics, and catalysis is inevitable. [4] During various research activities, such as fabricating advanced materials, as well as in the subsequent stage, i.e., industrial operations, new challenges have arisen that impact not only almost every aspect of human life but also other living creatures and ecosystems. It is estimated that the impact of these practices will endure into the next century. [5] Since the advancement of science, industry, and technology is inevitable, scientists have been persuaded to search for methods to counteract or minimize the negative impacts of human activities. [6] Thus, green chemistry has advanced and green principles have been defined for most sciences, including synthesis, [7] analytical chemistry, [8] engineering, [9] and pharmaceutical science. [10] Fortunately, contemporary society has great awareness of deleterious environmental side effects, resulting in a sense Advances in revolutionary technologies pose new challenges for human life; in response to them, global responsibility is pushing modern technologies toward greener pathways. Molecular imprinting technology (MIT) is a multidisciplinary mimic technology simulating the specific binding principle of enzymes to substrates or antigens to antibodies; along with its rapid progress and wide applications, MIT faces the challenge of complying with green sustainable development requirements. With the identification of environmental risks associated with unsustainable MIT, a new aspect of MIT, termed green MIT, has emerged and developed. However, so far, no clear definition has been provided to appraise green MIT. Herein, the implementation process of green chemistry in MIT is demonstrated and a mnemonic device in the form of an acronym, GREENIFICATION, is proposed to present the green MIT principles. The entire greenificated imprinting process is surveyed, including element choice, polymerization implementation, energy input, imprinting strategies, waste treatment, and recovery, as well as the impacts of these processes on operator health and the environment. Moreover, assistance of upgraded instrumentation in deploying greener goals is considered. Finally, future perspectives are presented to provide a more complete picture of the greenificated MIT road map and to pave the way for further development.

show abstract

Section: Green Strategies For Benign Mipsmentioning

confidence: 99%

Molecular Imprinting: Green Perspectives and Strategies

et al. 2021

View full text Add to dashboard Cite

show abstract

Section: Pfas Sensorsmentioning

confidence: 99%

“…Utilizing a similar mechanism, Glasscott et al designed a MIP-modified microelectrode to detect GenX and achieved ultrasensitive detection with a LOD of 82.5 pg/L (250 fM) ( Figure 3 g). 61 Garada et al used ion-transfer voltammetry to measure the lipophilicity and fluorophilicity of perfluoroalkanesulfonates and perfluoroalkanecarboxylates as well as to detect the concentration of PFOS ions. They employed poly(vinyl chloride) (PVC) membranes plasticized with 2-nitrophenyl octyl ether (oNPOE) as a selective membrane for PFAS ions.…”

Section: Pfas Sensorsmentioning

confidence: 99%

“… 51 The analyte of their selectivity studies was mostly PFOS, followed by PFOA, with one study focusing on GenX. 61 The concentrations of those PFAS analytes in most studies were quite high. If we take USEPA’s advisory level as a comparison, the concentration of PFOS or PFOA should be below 70 ng/L, which is 0.14 nM for PFOS and 0.17 nM for PFOA.…”

Section: Selectivity Toward Pfasmentioning

confidence: 99%

See 1 more Smart Citation

Selectivity of Per- and Polyfluoroalkyl Substance Sensors and Sorbents in Water

Darling

Chen

2021

ACS Appl. Mater. Interfaces

View full text Add to dashboard Cite

Per- and polyfluoroalkyl substances (PFAS) are a large group of engineered chemicals that have been widely used in industrial production. PFAS have drawn increasing attention due to their frequent occurrence in the aquatic environment and their toxicity to animals and humans. Developing effective and efficient detection and remediation methods for PFAS in aquatic systems is critical to mitigate ongoing exposure and promote water reuse. Adsorption-based removal is the most common method for PFAS remediation since it avoids hazardous byproducts; in situ sensing technology is a promising approach for PFAS monitoring due to its fast response, easy operation, and portability. This review summarizes current materials and devices that have been demonstrated for PFAS adsorption and sensing. Selectivity, the key factor underlying both sensor and sorbent performance, is discussed by exploring the interactions between PFAS and various probes. Examples of selective probes will be presented and classified by fluorinated groups, cationic groups, and cavitary groups, and their synergistic effects will also be analyzed. This review aims to provide guidance and implication for future material design toward more selective and effective PFAS sensors and sorbents.

show abstract

“…14 The monitoring of long-chain and new generation PFAS through fluorescence-based, optical and electrochemical sensors is giving promising results. [15][16][17][18] However, examples of biosensing platforms are still limited. 19 Transposing toxicological studies, particularly the ones focused on PFAS-protein interactions, to bioreceptor design is of great importance to develop new sensing platforms.…”

Section: Introductionmentioning

confidence: 99%