μ-opioid receptor genetic polymorphisms and duration of epidural fentanyl analgesia during early labor

Zgheib, Nathalie K.; Aouad, Marie T.; Taha, Samar K.; Nassar, Anwar H.; Masri, Riwa F.; Khoury, Mira Y.; Makki, Maha; Siddik-Sayyid, Sahar M.

doi:10.23736/s0375-9393.18.12697-6

Cited by 6 publications

(4 citation statements)

References 38 publications

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“…It is not permitted to frame or use framing techniques to enclose any trademark, logo, or other proprietary information of the Publisher. nulliparous women undergoing epidural fentanyl analgesia for labor; the authors found no difference in pain intensity, analgesia duration, side effects, and patient satisfaction in relation to three genetic polymorphisms: oPrM1 118a>g, ivs2+31g>a, and ivs2+691g>c. 140 the intraoperative use of opioids can affect the degree of postoperative analgesia by inducing hyperalgesia and tolerance. 141 Many studies showed that the n-methyl-D-aspartate receptor (nMDa) antagonist, ketamine is useful for both primary and secondary hyperalgesia after a variety of surgical procedures.…”

confidence: 99%

A year in review in Minerva Anestesiologica 2018

Cavaliere

Allegri²,

Apan

et al. 2019

Minerva Anestesiol

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confidence: 99%

A year in review in Minerva Anestesiologica 2018

Cavaliere

Allegri²,

Apan

et al. 2019

Minerva Anestesiol

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“…Ropivacaine is widely used in obstetric anesthesia due to its good analgesic properties while without resulting in motor blockade or systemic toxicity 10,11 . Fentanyl is an appropriate analgesic drug in use for labor because of its low molecular weight and high potency 12 . Some nonpharmacological pain management techniques include breathing techniques, water use, acupuncture/acupressure, massage, hypnotherapy, as well as transcutaneous electrical nerve stimulation (TENS) machine 13 .…”

Section: Introductionmentioning

confidence: 99%

“… 10 , 11 Fentanyl is an appropriate analgesic drug in use for labor because of its low molecular weight and high potency. 12 Some nonpharmacological pain management techniques include breathing techniques, water use, acupuncture/acupressure, massage, hypnotherapy, as well as transcutaneous electrical nerve stimulation (TENS) machine. 13 TENS machine relieves pain by activating descending inhibitory systems of the central nervous system with a low‐voltage electrical current.…”

Section: Introductionmentioning

confidence: 99%

Comparisons of nonpharmaceutical analgesia and pharmaceutical analgesia on the labor analgesia effect of parturient women

Zhu

Pan

Cao

2023

Immunity Inflam & Disease

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We aimed to compare the labor analgesia effects of nonpharmaceutical analgesia and pharmaceutical analgesia on parturient women.Methods: One hundred and four parturient women with spontaneous births were selected and randomly divided into pharmaceutical and nonpharmaceutical analgesia groups. Before and after analgesia, the Visual Analogue Scale (VAS), parturient satisfaction with analgesia, serum pain stress factors (substance P [SP], neuropeptide Y [NPY], nerve growth factor [NGF], and prostaglandin E2 [PGE2]), duration of labor, vaginal bleeding at 2 h postpartum, postpartum urinary retention and dysuria incidence, Apgar score of 1 min and 5 min after birth, and neonatal cord blood gas analysis (pH, partial pressure of oxygen [PO 2 ], partial pressure of carbon dioxide [PCO 2 ], and lactate [Lac]) were compared in the two groups.Results: VAS scores were lower and the analgesia satisfaction was higher in the pharmaceutical analgesia group than in the nonpharmaceutical analgesia group (all p < .05). Serum levels of SP, NPY, NGF, and PGE2 in the pharmaceutical analgesia group were lower than those in the nonpharmaceutical analgesia group (all p < .05). The first and second stages of labor were longer and the bleeding volume at 2 h postpartum was greater in the pharmaceutical analgesia group than those in the nonpharmaceutical analgesia group (all p < .05). Reduced Lac and PCO 2 levels and increased PO 2 level were found in the pharmaceutical analgesia group in comparison to the nonpharmaceutical analgesia group (all p < .05). Conclusion: This study demonstrates that the analgesic effect and neonatal condition of the pharmaceutical analgesia are better than the nonpharmaceutical analgesia, but the labor duration and postpartum bleeding volume of

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“…As a result, one branch of pain research focuses on single nucleotide polymorphisms (SNPs) in acute and inflammatory pain as potential objective pain markers. SNPs can act as predictors of pain intensity and may indicate an increased need for opioid analgesics in the perioperative period [17,18]. One potential SNP associated with differences in pain perception and opioid requirements is the A118G SNP in the mu-opioid receptor 1 (OPRM1) gene.…”

Section: Introductionmentioning

confidence: 99%

Mu-Opioid Receptor 1 and C-Reactive Protein Single Nucleotide Polymorphisms as Biomarkers of Pain Intensity and Opioid Consumption

Turczynowicz,

Jakubów,

Niedźwiecka

et al. 2023

Brain Sciences

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Children constitute a special group in pain therapy. Single nucleotide polymorphisms that are associated with differences in postoperative, inflammatory pain perception and opioid requirement are the A118G SNP in the mu-opioid receptor 1 (OPRM1) gene and the rs1205 CRP. This study aimed to determine connection between OPRM1 and rs1205 CRP SNPs in pediatric patients postoperatively and pain intensity, the opioid dose needed to control pain after scoliosis correction, and other clinical aspects. Genotypes of rs1205 CRP and OPRM1 polymorphisms in a sample of 31 patients were specified, and statistical analysis was performed in terms of age, genotype frequency, pain assessment, sufentanil flow, post-anesthesia care unit stay, and the use of coanalgesics. The frequency of A/A and A/G genotypes in the OPRM1 gene was in line with 1000Genomes data for the European population. Patients from the AG group of OPRM1 SNP more frequently required coanalgesics for adequate pain control; however, it was of weak statistical significance. Other parameters measured in the study were not statistically significant in relation to OPRM1 and CRP polymorphisms. The effect of SNPs on postoperative pain management and opioid therapy in children was not confirmed by this study. An expansion of the study sample and other opioid-related SNPs is required.

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μ-opioid receptor genetic polymorphisms and duration of epidural fentanyl analgesia during early labor

Abstract: OPRM1 SNVs did not affect the duration of epidural fentanyl administered for early labor analgesia in nulliparous women. These results should be confirmed in patients receiving epidural opioids in other clinical settings.

Cited by 6 publications

References 38 publications

A year in review in Minerva Anestesiologica 2018

A year in review in Minerva Anestesiologica 2018

Comparisons of nonpharmaceutical analgesia and pharmaceutical analgesia on the labor analgesia effect of parturient women

Mu-Opioid Receptor 1 and C-Reactive Protein Single Nucleotide Polymorphisms as Biomarkers of Pain Intensity and Opioid Consumption

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