An information base has been developed to ensure the need to modernize the company’s personnel policy for the effective functioning of the economic security management mechanism in the conditions of the Fourth Industrial Revolution and the realities of the BANI world. The need to transform the mechanism of managing the financial and economic security of economic entities and the personnel component of ensuring its functioning in accordance with the needs of the time has been substantiated. The risks of the Fourth Industrial Revolution, which must be taken into account in the management of the financial and economic security of the enterprise, have been identified and systematized. The list of personnel risks includes: low level of digital literacy of the staff; development of strategic plans by a person without professional training; employees’ use of unsecured channels for communication and work with information resources; elimination of personnel from many business processes (their automation); low level of hard skills when working with new equipment; low level of soft skills; excessive load of personnel with information, incl. information unnecessary for a specific employee; reluctance to lifelong learning and professional development, ineffective spending of time in the process of working with gadgets; careless attitude to the preservation and use of personal and corporate information. It has been determined what characteristics the financial and economic security management mechanism of the business entity should meet in order to ensure the effectiveness of its functioning and achieve the goal of its existence in the conditions of Industry 4.0. The main characteristics are: the systematic and consistent planning of innovations, specific clear KPIs and the periodicity of their evaluation, orientation towards the maximum level of digitalization, development and stimulation of leadership qualities in security specialists, the maximum number of diversified information and qualification technologies. Directions for modernization of personnel policy of enterprises in the realities of the Fourth Industrial Revolution and BANI World have been proposed with four priority vectors: personnel training, employee motivation, talent development and preservation of personnel potential. It has been established which personnel competencies are necessary for managing financial and economic security in the conditions of Industry 4.0. Among them: the use of gadgets to perform official duties, teamwork, information hygiene, information literacy, the ability to self-develop, time management, communication skills.