Annotation. The article is devoted to the study and comparison of the professionally important psychophysiological parameters of the operators of unmanned aerial systems (UAVs), practically healthy (40 people) and those suffering from stress-related diseases (80 people), who are serving in the Armed Forces of Ukraine. In patients with stress-associated diseases of UAVs operators, we found the significance of the changes in the indicators of the latent period of simple and complex visual-motor reaction, balance during the study of the reaction to a moving object, and the number of false marks when performing a concentration test with a reliability of p<0.05. The structure of the correlations of practically healthy and patients with stress-related diseases of UAVs operators in the parameters of concentration of attention, orientation in space and short-term visual memory are definitely different, which indicates a major restructuring of the functional system of the operators' professional activity in these aspects. Therefore, in order to prevent the occurrence of such changes, it is necessary to develop a set of organizational and medical measures to compensate for the negative impact of stress-associated diseases on the functional state of UAVs operators.