The paper summarized the experience of blended learning of students in quarantine conditions caused by the pandemic of the coronavirus infection COVID-19, which fundamentally changed the blended learning paradigm through the use of LMS Moodle and Google Classroom. The technical and methodological aspects of the implementation of blended learning are considered in the system of classical education. The didactic and methodological support of the educational process has been developed using LMS Moodle and Google Classroom. Using LMS Moodle, educational platforms have been created, both for students and for everyone, in the virtual educational environment of the university. It is shown that the use of LMS Moodle and Google Classroom tools is a new basis for independent work of students, since it completely changes and expands the format of learning: provides a complete electronic box of educational materials and resources during lectures and practical classes, creates an individual educational environment and sufficient methodological support for the chosen specialty. This is especially relevant to ensure quality education during the quarantine caused by the COVID-19 pandemic. Attention is focused on the need to structure educational training and teaching materials in such a way as to provide individual educational trajectories in the mode of synchronous and asynchronous learning with a mandatory system of monitoring and control of knowledge assimilation, in particular by means of LMS Moodle. A system of automated monitoring of knowledge control has been introduced, which is mandatory in the distance education system and includes initial, final control, self-control, an electronic journal with teachers’ grades and comments, which makes it possible for an individual approach to learning, improves the effectiveness of educational activities on the part of the student and increases motivation of teachers to use distance technologies through LMS Moodle and Google Classroom. The paper presents the results of a survey, which was attended by teachers who worked in the blended learning system during the quarantine caused by the coronavirus infection COVID-19 in March 2020 - June 2021 and used LMS Moodle and Google Classroom tools in their classes. Given the introduction of a blended learning system for students in a quarantine environment caused by the COVID-19 coronavirus pandemic, the described experience can be used not only in organizing the educational process, but also to form the prerequisites for creating an open learning system in the virtual educational environment of classical universities.