Дослідження Еег-Предикторів Нейромедіаторної І Нейрогліальної Активності У Хворих Із Гострою Церебральною Недостатністю Різного Генезу

Abstract

(0-1 Гц, 4-5 Гц, 5-6 Гц, 11-12 Гц, 24-25 Гц)

The Role of Cholinergic Insufficiency in Cognitive Impairment Among Patients With Chronic Cerebral Ischemia

“…Our results of researching EEG predictors of neurotransmitter and neuroglial activity in patients with chronic brain ischemia indicate a serious dysfunction of these systems: a significant increase in neuroglial, glutamatergic and adrenergic activity with a parallel decrease in cholinergic and dopaminergic activity [12].…”

“…Self-assessment of cognitive abilities on the part of the patient should be considered, taking into account the fact that cognitive disorders are often accompanied by a decrease in criticism [12].…”

“…Duplex scanning of extra-and intracranial vessels of the brain was carried out with the help of stenosis and deformation of the vessels of the head and neck, their hemodynamic significance, thickness and uniformity of the intima-media complex, and the presence of atherosclerotic changes were identified. To evaluate the patients' cognitive functions, a short scale for assessing the mental status of MMSE was used -Mini-mental State Examination (determining orientation in time and place, state of short-term, long-term memory, language function, gnosis, praxis) [12]. According to MMSE, 29-30 points were evaluated as the absence of cognitive impairment, 27-28 points -mild cognitive impairment, 24-26 -moderate cognitive impairment, 20-23 points -the initial stage of dementia, <20 -expressed stages of dementia.…”

“…According to MMSE, 29-30 points were evaluated as the absence of cognitive impairment, 27-28 points -mild cognitive impairment, 24-26 -moderate cognitive impairment, 20-23 points -the initial stage of dementia, <20 -expressed stages of dementia. Anxiety and depression were researched using the scale "Depression, Anxiety, Stress" (Depression Anxiety Stress Scales (DASS-21)) [12].The results of the survey determined normal, mild, moderate, strong and very strong degrees of depression, anxiety and stress. Investigations were conducted in the dynamics of treatment.…”