Еlеctrochemical characterization of phenytoin and its derivatives on bare gold electrode

Trišović, Nemanja; Božić, Bojan; Lović, Jelena; Vitnik, Vesna D.; Vitnik, Željko J.; Petrović, Slobodan; Ivić, Milka L. Avramov

doi:10.1016/j.electacta.2015.02.114

Cited by 15 publications

(19 citation statements)

References 32 publications

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“…The cyclic voltammogram obtained for a 1 mM CYS solution at a scan rate of υ = 50 mV s −1 (Fig. 1) shows one anodic peak at 0.873 V. On scanning in the negative direction, a reduction peak was observed; as in previous studies, this peak corresponds to the reduction of gold oxides [21,22] and demonstrates that the oxidation of CYS is an irreversible process. The decrease in the oxidation current observed in successive scans might be caused by the adsorption of CYS or its oxidation products on the GE surface.…”

Section: Voltammetric Behaviour Of Cysmentioning

confidence: 74%

Electrochemical studies for the determination of an antibiotic drug, d-cycloserine, in pharmaceutical and human biological samples

Pattar

Nandibewoor

2016

Journal of Taibah University for Science

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An antibiotic drug, d-cycloserine (CYS), in phosphate buffer at different pH values was electrochemically studied using a gold electrode. A well-resolved, irreversible, diffusion-controlled voltammetric peak was obtained at 0.873 V in a pH 9.2 phosphate buffer solution with an ionic strength of 0.2 M. The experimental conditions, such as the solution pH and scan rate, were optimized. The pH dependence suggested that equal numbers of protons and electrons were involved in the electrochemical oxidation of CYS. A plausible oxidation mechanism was proposed. Under the selected conditions, the dependence on the concentration of CYS revealed that the detection limit for CYS was 3.3 × 10 −8 M for differential pulse voltammetry and 4.91 × 10 −8 M for square wave voltammetry. The proposed method was successfully applied to the determination of CYS in drug capsules and urine samples. The electrode exhibits good reproducibility and stability. In addition, the influence of various foreign species was studied.

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Section: Voltammetric Behaviour Of Cysmentioning

confidence: 74%

Electrochemical studies for the determination of an antibiotic drug, d-cycloserine, in pharmaceutical and human biological samples

Pattar

Nandibewoor

2016

Journal of Taibah University for Science

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“…Standard equipment, PGZ 402 Volta Lab (Radiometer Analytical, Lyon, France) has been used for the electrochemical measurements and the three electrode electrochemical cell was described in detail previously [23]. Polycrystalline gold (0.07 cm 2 ) served as the working electrode and a gold wire as the counter electrode.…”

Section: Apparatus and Preparation Of Electrode Surfacesmentioning

confidence: 99%

“…All the potentials are given vs. saturated calomel electrode (SCE) used as the reference one. Preparation and activation of gold electrode was described previously [23]. Electrolyte, 0.05 M NaHCO 3 (pH = 8.4) was previously deoxygenated by purging with nitrogen at room temperature.…”

Section: Apparatus and Preparation Of Electrode Surfacesmentioning

confidence: 99%

Investigation of electrochemical behavior of anisomycin on gold electrode followed by HPLC–MS/MS analysis

Tolić

Lović

Petrović

et al. 2015

Electrochemistry Communications

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Anisomycin is an immunosuppressant in low doses (b0.1 μM) with possible application in treatment of some autoimmune diseases and in inhibiting transplantation rejection. Anisomycin suppresses malignant tumor cell growth and affects memory. For the first time it was the subject of the electrochemical investigations by cyclic voltammetry and square wave voltammetry on gold electrode in 0.05 M NaHCO 3 using its electrochemical activity. The cyclic voltammetry experiments at different sweep rates show that electrochemical process is irreversible and diffusion controlled. Based on square wave voltammetry measurements, the calculated values of LOD and LOQ were 1 and 4 nM (in the absence of biological fluid), as well as 2 and 6 nM (in the presence of spiked urine) indicating the high sensitivity of the proposed electroanalytical method. High performance liquid chromatography-tandem mass spectrometry was a reference method for quantification of anisomycin and served for structural identification of its hydrolysis product (deacetylanisomycin).

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“…However since these methods are laborious, expensive and needed specialists to be conducted, more practical and economical methods like electrochemical methods are needed . The literature survey demonstrated that there are two electrochemical based methods for the examination of phenytoin . In the first study, where glassy carbon electrode (GCE) has been utilized as a working electrode, oxidation mechanisms of some hydantoin derivatives has been proposed which allow us to understand the important aspects of structure‐activity relationships .…”

Section: Introductionmentioning

confidence: 99%

“…In another work, gold (Au) electrode was used and electrochemical characterization of phenytoin and its derivatives were done where obtained results were supported by computational study. In this context a calibration graph was also provided …”

Section: Introductionmentioning

confidence: 99%

Development of Practical Electrochemical System for Phenytoin Detection

2019

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In this work a practical electrochemical approach has been developed by using gold (Au)-film electrode for phenytoin detection. The formation of Au-film was monitored by using scanning electron microscopy, energy dispersive X-ray spectroscopy and X-ray photoelectron spectroscopy techniques. After the electrochemical characterization, the experimental conditions were optimized and then the analytical characterizations were examined. As a result, two linear ranges were found between 5x10 À 7 M and 2x10 À 4 M with the limit of detection and limit of quantification values as 0.302 μM and 1.013 μM respectively. The developed system was applied for phenytoin detection in synthetically prepared plasma solution and as a result recovery value of 99.5% � 0.056 was obtained.[a] T.

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Еlеctrochemical characterization of phenytoin and its derivatives on bare gold electrode

Cited by 15 publications

References 32 publications

Electrochemical studies for the determination of an antibiotic drug, d-cycloserine, in pharmaceutical and human biological samples

Electrochemical studies for the determination of an antibiotic drug, d-cycloserine, in pharmaceutical and human biological samples

Investigation of electrochemical behavior of anisomycin on gold electrode followed by HPLC–MS/MS analysis

Development of Practical Electrochemical System for Phenytoin Detection

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