Инъекционный Коллаген В Коррекции Возрастных Изменений Кожи: Экспериментально-Клинические Параллели

Мантурова, Н.Е.; Stenko, A.G.; Петинати, Я А; Чайковская, Е А; Bolgarina, A. A.

doi:10.24075/vrgmu.2019.010

Cited by 5 publications

(4 citation statements)

References 30 publications

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“…Коллаген составляет до 25% (по сухому весу) от всех белков в организме человека, что является основой соединительной ткани, в том числе и кожи [2]. Большое количество современных методик эстетической медицины направлено на улучшение, стимуляцию синтеза коллагеновых волокон в коже [3]. При этом часть компаний приводит результаты клинических испытаний, согласно которым применение той или иной методики приносит значимый результат по данным клинических и гистологических исследований.…”

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Collagen synthesis in the skin: genetic and epigenetic aspects

et al. 2022

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One of the most important functions of the skin, mechanical, is provided by collagen fibers and their interaction with other elements of the extracellular matrix. Synthesis of collagen fibers is a complex multistep process. At each stage, disturbances may occur, leading, as a result, to a decrease in the mechanical properties of the connective tissue. In clinical practice, disorders of collagen synthesis are manifested through increased skin laxity and looseness and premature aging. In addition to the clinical presentation, it is important for the cosmetologist and dermatologist to understand the etiology and pathogenesis of collagenopathies. The present review summarizes and systematizes available information about the role of genetic and epigenetic factors in the synthesis of collagen fibers in the skin. Understanding the etiology of collagen synthesis disorders can allow doctors to prescribe pathogenetically grounded treatment with the most effective results and minimize adverse reactions.

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Collagen synthesis in the skin: genetic and epigenetic aspects

et al. 2022

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“…Актуальность данного исследования связана со стремительным развитием косметологических процедур в эстетической медицине [1,2]. Инъекционные методики активно используются и занимают лидирующие позиции в инъекционной косметологии [3,4,5]. В частности, популярна мезотерапия для коррекции возрастных изменений кожи лица и тела, связанных со старением [6,7].…”

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Influence of preparations with peptides on innate and adaptive immunity

Sizyakina,

Sergeeva

2023

Med. vestn. Ûga Ross.

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Objective: to assess the dynamics of the immune system functioning when using mesotherapy with peptide complexes. Materials and methods: the observation group consisted of 26 women (from 35 to 55 years old) who received a course of mesotherapy with preparations containing peptides for the first time. Injections were carried out in a course of 5 procedures with an interval of 14 days. The exclusion criteria were the absence of same manipulations in the past, hormone replacement therapy, combined oral contraceptives, pregnancy, lactation, acute infections, somatic pathologies. The parameters of innate and adaptive immunity were studied before the course of procedures, right after it, 3 and 6 months after the course. Skin quality changes were assessed using the Aramo Smart Lite 300 dermatoscope. Results: improved skin quality, decreased skin creases, increased skin moisture. The obtained clinical improvements last for three months after the end of the course and there is a tendency for the effects to decrease after six months. In the functioning of the immune system, there is a redistribution of lymphocytes population in the peripheral bloodstream immediately after the course of mesotherapy. In addition, an increase in peripheral T-regulatory lymphocytes responsible for intraimmune suppression was documented. The activation of spontaneous oxygen-producing activity was noted. 3 months after the procedure, no significant changes in immunological parameters were found. 6 months after the course of procedures, a decrease in the level of T-lymphocytes with an increase in the expression of markers of early T-cell activation was recorded. In the humoral link, an increase in circulating B-lymphocytes was documented. In the parameters of innate immunity, there is a decrease in the spontaneous oxygen-producing activity of neutrophils. Conclusion: as a result of the study, a positive persistent clinical effect is documented, simultaneously with the mobilization of factors of innate and adaptive immunity. It is important to note the fact that the immune response restores completely within 6 months after a course of mesotherapy with peptide complexes, with still noticeable clinical results.

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“…Collagen makes up 25% (in dry weight) of all proteins in the human body, constituting the basis of connective tissue, including skin [2]. Many modern methods of aesthetic medicine are aimed at improving or stimulating the synthesis of collagen fibers in the skin [3]. Furthermore, various companies have undertaken clinical trials and histological studies and have suggested that particular techniques bring significant results.…”

Section: Introductionmentioning

confidence: 99%

Genetic and Epigenetic Aspects of Skin Collagen Fiber Turnover and Functioning

et al. 2021

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One of the most important functions of the skin, i.e., protection from mechanical damage, is ensured by collagen fibers and their interaction with other elements in the extracellular matrix. Collagen fiber turnover is a complex multi-stage process. At each stage, a disruption may occur, leading to a decrease in the mechanical properties of the connective tissue. Clinically, collagen formation disorders manifest themselves as increased flabbiness and looseness of the skin and as early signs of facial aging. In addition to the clinical picture, it is important for cosmetologists and dermatologists to understand the etiology and pathogenesis of collagenopathies. In our review, we summarized and systematized the available information concerning the role of genetic and epigenetic factors in skin collagen fiber turnover. Furthermore, we focused on the functions of different types of collagens present in the skin. Understanding the etiology of impaired collagen formation can allow doctors to prescribe pathogenetically based treatments, achieve the most effective results, and minimize adverse reactions.

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Инъекционный Коллаген В Коррекции Возрастных Изменений Кожи: Экспериментально-Клинические Параллели

Cited by 5 publications

References 30 publications

Collagen synthesis in the skin: genetic and epigenetic aspects

Collagen synthesis in the skin: genetic and epigenetic aspects

Influence of preparations with peptides on innate and adaptive immunity

Genetic and Epigenetic Aspects of Skin Collagen Fiber Turnover and Functioning

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