Клініко-Анамнестична Характеристика Та Перебіг Госпітального Періоду Захворювання У Хворих Молодого Віку З Гострим Коронарним Синдромом З Елевацією Сегмента ST

Abstract

The aim – to compare the clinical, anamnestic characteristics and course of in-hospital period in patients of different age groups with ST-elevation acute coronary syndrome.
 Material and methods. Were analyzed the data of 835 patients with ST-elevation acute coronary syndrome admitted to the emergency departments from January 2000 to December 2015. Patients were divided into two groups: I group – < 45 years of age (n=189), II group ≥ 45 years (n=646).
 Results. The average age of patients in the I group was (37.8±6.5) years, in the II group – 59.3±8.1 years (Р<0.0001). Among the patients in group I there were more men (Р<0.0001). The mean body mass index (BMI) in young patients was 28.7±4.6 kg/m2 compared to 27.8±4.2 kg/m2 in group II (Р<0.021). The frequency of diabetes mellitus in patients of the I group was 4.2 %, arterial hypertension – 41.8 %. Young patients were much less likely to have a history of myocardial infarction or stroke and concomitant heart failure. The anterior localization of myocardial infarction in group I patients was registered in 59.8 % cases vs 51.9 % in the II group, Р=0.045; there were no significant differences regar­­ding frequency of posterior and lateral infarctions. The average time from the development of symptoms to hospitalization in the I group was 9.7±7.6 hours, and in group II – 4.5±5.3 hours (Р<0.001).
 Conclusions. Patients under 45 years of age with ST-elevation acute coronary syndrome are heterogeneous. The most important risk factors for the development of AMI in these patients are smoking, overweight and heredity. Hypertension and diabetes mellitus in young patients were much less frequent than in the older age group. In-hospital course of AMI in young patients was more favorable with fewer complications.