Медико-Дозиметрический Регистр Персонала Сибирского Химического Комбината – База Для Оценки Эффектов Хронического Облучения

Takhauov, R. M.; Карпов, А. Б.; Зеренков, А. Г.; Овчинников, А. В.; Изместьев, К. М.; Спасибенко, П. В.; Богданов, И. М.; Казанцева, С. Б.; Семенова, Ю В; Калинкин, Д. Е.; Горина, Г. В.; Максимов, Д. Е.; Блинов, А. П.; Rodionova, Vlada; Brendakov, V. N.; Ермолаев, Ю. Д.; Миронова, Е. Б.; Борисова, Е. Г.; Брендаков, Р. В.; Плаксин, М. Б.; Некрасов, Г. Б.; Изосимов, А. С.; Гагарин, А. А.

doi:10.7868/s0869803115050124

Cited by 5 publications

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“…Данные об индивидуальных дозах внешнего облучения, измеренных с помощью фотопленочных и термолюминесцентных дозиметров, были получены из отдела охраны труда, ядерной и радиационной безопасности ОИИИ. Источником медицинской информации являлся архив медицинской документации и электронная база данных ББМ СБН Центра [8,9]. Накопленная доза ИИ у работников, участвовавших в исследовании, за эти годы либо не изменилась, либо изменилась незначительно.…”

Section: материал и методыunclassified

Comparative Retrospective Analysis of the Results of Cytogenetic Studies of Employees of the Object of Use of Ionizing Radiation

Vishnevskaya,

Isubakova,

Tsyplenkova

et al. 2024

MEDICAL RADIOLOGY AND RADIATION SAFETY

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Purpose: To conduct a comparative retrospective analysis of the results of cytogenetic studies of workers at facilities using ionizing radiation in 2003 and 2018. Material and methods: The material for the study was the venous blood of workers at facilities using ionizing radiation. The study was conducted on conditionally healthy workers (n = 11), of which 2 groups were formed: the control group (blood sampling and cytogenetic study of blood lymphocytes were carried out in 2003) and the study group (blood sampling was carried out in 2018). For all examined individuals, blood lymphocytes were cultured and standard cytogenetic analysis followed by statistical processing of the results. Results: A comparative retrospective analysis showed that in the study group (2018) compared to the control group (2003), the frequency of chromatid fragments was reduced (p = 0.0452). The frequencies of other types of cytogenetic disorders studied (aberrant cells, chromosomal fragments, dicentric and circular chromosomes) do not differ between groups. Cytogenetic abnormalities in blood lymphocytes are a highly sensitive measure of the degree of radiation exposure in the early and late periods after exposure and can be used as a biological indicator of ionizing radiation. The absence of differences in indicators of radiation exposure markers may be due to the large interval of time that elapsed after irradiation until the moment of examination (15 years), during which lymphocytes with chromosomal aberrations were eliminated from the blood. In the future, for the completeness of the retrospective analysis and the accuracy of the result, it is planned to conduct a study on a larger sample with a shorter time interval between cytogenetic studies. Conclusion: The result of this work allows us to supplement the understanding of the mutation process in the somatic cells of individuals exposed to ionizing radiation in the course of professional activities and indicates genotoxicity.

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Section: материал и методыunclassified

Comparative Retrospective Analysis of the Results of Cytogenetic Studies of Employees of the Object of Use of Ionizing Radiation

Vishnevskaya,

Isubakova,

Tsyplenkova

et al. 2024

MEDICAL RADIOLOGY AND RADIATION SAFETY

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“…В связи с высокими возможностями репаративных процессов высока вероятность развития опухоли в короткий латентный период (2-5 лет), типичный для острого лейкоза [2,3]. Для солидных опухолей он, как правило, более продолжителен и составляет не менее 5-10 лет [4][5][6].…”

Section: эпидемиологические исследованияunclassified

“…Так, в работе, объединяющей данные для трех стран -США, Великобритании и Канады, установлен повышенный уровень лейкемии, за исключением хронической лимфатической лейкемии, для работников радиационно опасных предприятий, подвергшихся облучению в диапазоне доз 0-400 мЗв. Относительный риск лейкемии оценён как 2,18 на 1 Зв, при этом повышенного риска развития солидных раков не установлено [5,14].…”

Section: эпидемиологические исследованияunclassified

“…Целью исследования являлась оценка заболеваемости ЗНОЛТ среди подвергавшегося долговременному радиационному воздействию персонала Сибирского химического комбината (СХК). Принципы формирования регистра, основные источники информации, методология дозиметрического контроля, а также подробная характеристика когорты персонала СХК были представлены в публикациях ранее [5]. Изучаемая когорта включала всех работников основного и вспомогательного производств СХК, нанятых в период с 01.01.1950 по 31.12.2000.…”

Section: эпидемиологические исследованияunclassified

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Assessment of Lymphoid Neoplasm Risk Factors in People Occupationally Exposed to Prolonged Ionizing Radiation

et al. 2020

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Objective: To estimate the incidence of malignant neoplasms of lymphoid tissue (MNLT) among employees of the siberian chemical combine (SCC) occupationally exposed to prolonged ionizing radiation.Material and methods. The study included 44,041 employees of the SCC, of whom 16,938 were occupationally exposed to prolonged low-intensity ionizing radiation (IR). Of 295 cases with hemoblastoses, there were 89 with occupational exposure to IR. The structure and incidence of hemoblastoses (based on the number of person-years of observation, (PYO), as well as the standardized relative risk (SRR) of their development and excess relative risk (err) per unit dose of radiation (GR) were evaluated. Calculation of SRR was carried out for the following intervals of the total dose of external exposure: 0; >0–0.05; >0.05–0.10; >0.10-0.15; >0.15–0.20; >0.20-0.30; >0.30-0.50; >0.5–1.0; ≥ 1.0 Gy. The control group consisted of occupationally non-exposed employees of the SCC. The calculation of SRR and err was performed using the poisson regression using the amfit module of the EPICURE package.Results. The incidence of MNLT among males of SCC was 17.1 per 100,000 PYO, with the highest incidence rates for Non-Hodgkin’s lymphoma (NHL), chronic lymphocytic leukemia (CLL) and chronic leukemia (CL) excluding CLL. Among females of the SCC, the incidence of MNLT was 21.3 per 100,000 PYO. It was found that in none of the intervals of the external exposure there was no statistically significant excess of the SRR compared with the control group. The results of ERR/GY calculation also did not demonstrate the increased risk of hemoblastosis among people occupationally exposed to IR.Conclusion. Occupational exposure in the studied dose range does not increase the risk of developing MNLT.

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Industry Workers of Russia and Great Britain

Kuznetsova

Gillies

2020

Medical Radiology and Radiation Safety

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Purpose: The estimation of the radiation risk of leukemia incidence and mortality for occupational exposure. Material and methods: The study was conducted in the pooled cohort comprised 45,817 workers from the two enterprises; 23,443 radiation workers first employed in 1947–2002 from the Sellafield plant (Great Britain) and 22,774 workers from the Mayak PA (Russia) first employed at the main plants in 1948–1982. The period of follow-up was terminated at the end of 2008 for Mayak workers who were Ozyorsk city residents, and at the end of 2005 for Sellafield workers and Mayak workers who had migrated from Ozyorsk. Results: Comparable radiation risk estimates of leukemia incidence and mortality were found among Mayak PA and Sellafield workers as for the whole dose range and separate dose intervals. Averaged by attained age estimate of excess relative risk per 1 Gy of external gamma-dose was 3.0 (95 % CI: 1.3–6.3) under the assumption of the linear dose–effect model. The quadratic model with attained age modification showed the best quality of fit. Risk estimates were statistically significant in the dose range 0.15–1.5 Gy. There was no evidence of any relationship between leukemia risks and accumulated red bone marrow dose of internal alpha-exposure due to incorporated Pu-239. Conclusion: Preliminary analysis of the pooled cohort data has demonstrated the feasibility and efficiency of a research project looking at leukemia risks in a joint cohort of Mayak and Sellafield workers. The current study provides further evidence about the already well established link between external-gamma exposure and leukemia risk. However, it fails to provide any firm further evidence about the absence or presence of relationship between plutonium exposure and leukemia risk.

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Медико-Дозиметрический Регистр Персонала Сибирского Химического Комбината – База Для Оценки Эффектов Хронического Облучения

Cited by 5 publications

References 0 publications

Comparative Retrospective Analysis of the Results of Cytogenetic Studies of Employees of the Object of Use of Ionizing Radiation

Comparative Retrospective Analysis of the Results of Cytogenetic Studies of Employees of the Object of Use of Ionizing Radiation

Assessment of Lymphoid Neoplasm Risk Factors in People Occupationally Exposed to Prolonged Ionizing Radiation

Industry Workers of Russia and Great Britain

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