Objective: To estimate the incidence of malignant neoplasms of lymphoid tissue (MNLT) among employees of the siberian chemical combine (SCC) occupationally exposed to prolonged ionizing radiation.Material and methods. The study included 44,041 employees of the SCC, of whom 16,938 were occupationally exposed to prolonged low-intensity ionizing radiation (IR). Of 295 cases with hemoblastoses, there were 89 with occupational exposure to IR. The structure and incidence of hemoblastoses (based on the number of person-years of observation, (PYO), as well as the standardized relative risk (SRR) of their development and excess relative risk (err) per unit dose of radiation (GR) were evaluated. Calculation of SRR was carried out for the following intervals of the total dose of external exposure: 0; >0–0.05; >0.05–0.10; >0.10-0.15; >0.15–0.20; >0.20-0.30; >0.30-0.50; >0.5–1.0; ≥ 1.0 Gy. The control group consisted of occupationally non-exposed employees of the SCC. The calculation of SRR and err was performed using the poisson regression using the amfit module of the EPICURE package.Results. The incidence of MNLT among males of SCC was 17.1 per 100,000 PYO, with the highest incidence rates for Non-Hodgkin’s lymphoma (NHL), chronic lymphocytic leukemia (CLL) and chronic leukemia (CL) excluding CLL. Among females of the SCC, the incidence of MNLT was 21.3 per 100,000 PYO. It was found that in none of the intervals of the external exposure there was no statistically significant excess of the SRR compared with the control group. The results of ERR/GY calculation also did not demonstrate the increased risk of hemoblastosis among people occupationally exposed to IR.Conclusion. Occupational exposure in the studied dose range does not increase the risk of developing MNLT.

Personnel safety is a priority when decommissioning obsolete nuclear facilities. The study was aimed to develop the methodological basis for the medical and sanitary support of the nuclear industry enterprise personnel radiation safety during the nuclear legacy elimination on the example of Siberian Chemical Plant (SCP, Seversk). The study involved the data of the SCP employees' medical and dosimetric register containing information about all cases of death (with an indication of the cause) of former and current employees of the enterprise. The study results were used to justify selection of the area for development of scientific and methodological support of activities in the field of medical and sanitary support of radiation safety during the nuclear legacy elimination. Death rates and the risk of dying from cancer of certain localizations (trachea, bronchi, lung, skin, stomach, colon, lymphoid, hematopoietic and related tissues, breast and prostate glands) in the nuclear industry enterprise employees were assessed. The directions for improving the medical support of the nuclear enterprise employees and the population of the surveillance zones during the nuclear legacy elimination were defined. The findings will make it possible to adjust the medical support of the nuclear industry enterprise employees in order to extend their working longevity, as well as to reduce the adverse radiation-induced health effects in people engaged in the nuclear legacy elimination.

The study involved an analysis of the dynamics of dermatological and oncological diseases [epithelial malignant skin neoplasms (С44), malignant skin melanoma (С43)] conducted among the population of the town of Seversk in 1970- 2009. A growth in the incidence rate of malignant skin neoplasms in 2000-2009 was revealed; it was established that such data exceed similar indices for the Tomsk region

Background. One of the main directions in the field of ensuring radiation safety of “nuclear legacy” facilities is the assessment of radiation effects and most significant radiogenic risks in employees of nuclear enterprises and their descendants.Objective. Analysis of the cancer incidence among employees of the Siberian Group of Chemical Enterprises (SGCE) exposed to ionizing radiation in the course of their professional activities.Material and Methods. The actual values and standardized estimated risks of developing cancer among the SGCE workers occupationally exposed to ionizing radiation were calculated using generally accepted methods based on the information of the regional medical dosimetry registry of Seversk Biophysical Research Center of FMBA, containing updated data on all SGCE employees diagnosed with cancer (period from 01.01.1950 to 31.12.2015 inclusive). The control group consisted of workers who were not occupationally exposed to ionizing radiation.Results. Among the male personnel of the SGCE, the highest incidence of cancer of the digestive, respiratory, and skin organs (including melanoma) was observed in patients aged 50–59 and 70–79 years. Among the female workers, the highest cancer incidence was in the age group 40–49 years; cancer of the gastrointestinal tract, genital tract and breast was the most common. The cancer incidence rate in the SGCE workers who occupationally exposed to ionizing radiation was not higher that that observed in the control group. The median age of male cancer patients occupationally exposed to ionizing radiation was significantly lower than the median age of male cancer patients of the control group. In female cancer patients, a significant difference in the median age of cancer diagnosis was found only in relation to skin cancer. Both male and female SGCE personnel occupationally exposed to ionizing radiation was at high risk of certain cancers: among male patients – cancer of the mesothelium and soft tissues, genital organs, eyes and brain, as well as multiple primary tumors; among female patients – cancer of lips, oral cavity, pharynx, digestive system, respiratory system, skin (including melanoma), mesothelium, soft tissues, breast, urinary tract, lymphatic and hematopoietic tissues, as well as multiple primary tumors.Conclusion. The data obtained will allow determination of the main directions for assessing the health risks of personnel of radiation hazardous facilities and the formation of a set of measures aimed at improving the system of protection and improving the health of workers at radiation hazardous enterprises and the extension of their working longevity.