Нейроиммунология: Теоретические И Клинические Аспекты

Столяров, И. Д.; Петров, А. М.; Вотинцева, М. В.; Ивашкова, Е. В.

doi:10.7868/s0131164613010153

Cited by 2 publications

(2 citation statements)

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“…Особую опасность свинец представляет для женщин, так как он обладает способностью проникать через плаценту [16], а также накапливаться в грудном молоке [17]. Показано, что при хронической интоксикации свинцом у женщин резко падает иммунитет [18] и значительно возрастает число гинекологических заболеваний. Свинец активно влияет на биосинтез белка, энергетический обмен в клетке и на ее генетический аппарат [19].…”

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Environmental aspects of primers and prospects for their improvement

Zhulikov,

Tikhonov,

Dudnik

et al. 2023

Mining Industry Journal

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The main primers in the mining industry are blasting caps with highly toxic energy-intensive priming materials based on lead compounds. Unfortunately, behind the detailed complexity of modern approaches to calculate the environmental damage, it is rather difficult to assess the specific indicators of lead emissions from the blasting caps, therefore, an alternative option is presented, which allows to demonstrate a more explicit equivalent of the negative consequences. Analysis of statistical data on production and consumption of lead-containing primers indicates their significant contribution to the total and annually increasing pollution of the environment with lead, emphasizing the need to seek alternative energy-intensive priming materials. The current stage of global engineering and technological development has witnessed alternative primers already introduced into production and use, but still somewhat controversial in terms of some performance specifications and manufacturing technologies, which are utilizing new compounds that do not contain heavy metals. They are also based on fundamentally new methods of blast initiation in energy-intensive materials, in particular, using the effects of radiation from optical quantum generators (lasers). The combination of the presented environmental factors and scientific and technological achievements point to the need to intensify domestic research and development to replace highly toxic primers.

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Environmental aspects of primers and prospects for their improvement

Zhulikov,

Tikhonov,

Dudnik

et al. 2023

Mining Industry Journal

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“…Бехтеревой РАН оценка повреждений ЦНС и иммунной системы при РС проводится с применением как клинических неврологических, так и радиологических нейровизуализационных и иммунологических методов. Помимо рутинных исследований по изучению иммунного статуса пациентов с РС на фоне патогенетической терапии [16], нами проводятся исследования особенностей вовлечения белого и серого вещества головного мозга в демиелинизирующий патологический процесс при различных типах течения РС [17,18], анализируются уровни и дифференцировка ключевых иммуноцитов, когнитивные и двигательные нарушения в зависимости от степени выраженности неврологического дефицита при РС [19,20].…”

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Safety of pathogenetic therapy for multiple sclerosis during the COVID-19 pandemic

Петров

Вотинцева

Stolyarov

2022

Annals of Clinical and Experimental Neurology

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The safety of pathogenetic therapy for multiple sclerosis (MS) is a crucial aspect of the therapeutic strategy during the COVID-19 pandemic. Based on our own data, obtained during the study of MS pathogenesis and safety analysis of MS disease-modifying therapies (DMTs), we hereby suggest a classification of DMTs side effects, based on their type, development, and direction of action. There is a need to thoroughly analyse adverse events caused by pathogenetic therapy, with a balanced assessment of the direct vs. adverse effects of immunosuppressive drugs. Based on available literature, in the article, data on the effect of DMTs with various mechanisms of action on severe coronavirus infection are systematized. Interferon- and glatiramer acetate are the safest drugs to use during the COVID-19 pandemic. Teriflunomide, dimethyl fumarate, natalizumab, ocrelizumab, fingolimod, alemtuzumab, and cladribine should be used with caution. Drugs with a minor systemic immunosuppressant effect (e.g. natalizumab) and selective immunosuppressants (e.g. ocrelizumab) are safer than drugs that cause non-selective depletion of T and B cells. It must be stressed that the risk of MS exacerbation and progression due to untimely prescription or cessation of pathogenetic therapy can significantly exceed the potential risk of COVID-19. Long-term safety monitoring is required for DMTs during the COVID-19 pandemic and when the epidemiological situation stabilizes.

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Нейроиммунология: Теоретические И Клинические Аспекты

Cited by 2 publications

References 0 publications

Environmental aspects of primers and prospects for their improvement

Environmental aspects of primers and prospects for their improvement

Safety of pathogenetic therapy for multiple sclerosis during the COVID-19 pandemic

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