Парацетамол Среди Средств Суицидальных Действий В России И Зарубежом

Зотов, П.Б.; Борисович, Любов Евгений; Рафаиловна, Абузарова Гузель; Геннадьевич, Скрябин Евгений; Михайлович, Кляшев Сергей; Геннадьевич, Петров Виктор

doi:10.32878/suiciderus.19-10-04(37)-99-119

Cited by 3 publications

(2 citation statements)

References 48 publications

(223 reference statements)

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“…На госпитальном этапе парацетамол может быть использован путем парентерального введения. Использование парацетамола имеет очень широкий спектр, учитывая его многообразие форм выпуска [10].…”

Section: бронхопульмонология и отоларингологияunclassified

“…В Европе показатели смертности от токсического повреждения печени, вызванного передозировкой парацетамола, значительно различаются. Например, в Ирландии этот показатель составляет 52%, в Великобритании -28%, во Франции -18%, в Нидерландах -8%, а в Италии -всего 1% [10].…”

Section: бронхопульмонология и отоларингологияunclassified

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Paracetamol and ibuprofen in the treatment of pain and fever in children: modern views on the choice of a drug

Zakharova,

Berezhnaya,

Pupykina

et al. 2023

Medicinskij sovet

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Paracetamol (acetaminophen) and ibuprofen are commonly used to relieve fever and pain in children. Their effects are similar, but differ in strength and mechanisms of action on the body. Acetaminophen, a para-aminophenol derivative, has antipyretic and analgesic properties. Despite the fact that paracetamol has been officially used as a drug for more than 75 years, its mechanism of biological action has not been sufficiently studied. In paediatric practice, paracetamol is more often used as an antipyretic, but in recent years, with the development of technology and emergence of new dosage forms on the market, it came into common use as an analgesic in many diseases, including oncological, rheumatological, etc. Ibuprofen is the most commonly used non-steroidal anti-inflammatory drug with pronounced analgesic and antipyretic properties. Ibuprofen, a non-selective inhibitor of cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2), affects the hypothalamic thermoregulatory center via inhibition of prostaglandin synthesis. In the paediatric population, the most common indications for the use of ibuprofen are fever, sore throat, ear pain, headache and toothache, post-traumatic and musculoskeletal pain, and inflammatory joint diseases. Paracetamol and ibuprofen are safe for use in paediatric practice, if dosing rules are observed, and are approved for use by the World Health Organization, FDA and other expert organizations. In addition, the emergence of new presentation forms of these drugs is most important in paediatrics.

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Section: бронхопульмонология и отоларингологияunclassified

Paracetamol and ibuprofen in the treatment of pain and fever in children: modern views on the choice of a drug

Zakharova,

Berezhnaya,

Pupykina

et al. 2023

Medicinskij sovet

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Acute Chemical Poisoning in an Industrial City: Current Situation, Dynamics and Forecast

Marchenko,

Deryabkina,

Nesterova

et al. 2023

PH&LE

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Introduction: The urgency of the problem of acute chemical poisoning is attributed to the fact that it is the cause of poor health, disability and premature death of the population, as well as a significant medical and socio-economic damage. Objective: To conduct a retrospective and prospective epidemiological study of acute chemical poisoning based on the results of toxicological monitoring in the city of Taganrog for 2008–2022. Materials and methods: We carried out a comprehensive analysis of statistical reporting forms and a personalized database of 2,466 cases of acute chemical poisoning registered in the city of Taganrog, Rostov Region, in 2008–2022. To do this, we used software of our own design and professional software packages IBM SPSS Statistics version 19.0 and Matlab R2021a with a set of tools for synthesizing and analyzing neural networks Neural Network Toolbox. Results: Over the 15-year period under study, trends towards a decrease in the rates of acute chemical poisoning, mortality and lethality had formed, as confirmed by a favorable assessment of the situation based on regional criteria and actual risk indicators. Alcohol surrogates, pharmaceutical drugs, and carbon monoxide remain the priority etiological causes of poisoning. Relatively high rates were observed among children aged 0–6 not attending preschools and schoolchildren aged 7–17, as well as among the unemployed and pensioners, which allowed us to attribute them to risk groups. High accuracy of forecasts generated using artificial neural networks has been confirmed. Conclusion: The results of toxicological monitoring are the basis for assessing the situation and optimizing toxicological care, both necessary for managerial decision-making and elaboration of targeted chemical safety programs.

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Paracetamol Poisoning: Epidemiology, Diagnosis, Treatment (Status of the Issue)

Sentsov,

Gusev,

Davydova

et al. 2024

Урал. мед. журнал

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Introduction. Paracetamol (acetaminophen) is an over-the-counter analgesic and antipyretic drug, available in monoform and included in more than 200 combined drugs. Today, paracetamol is widely used in medicine, and therefore available in different age categories, including children from 0 to 18 years old, adults, the elderly and pregnant women.The aim is to systematize data on the epidemiology, diagnosis and treatment of paracetamol poisoning based on data from foreign and domestic literature.Materials and methods. Literary search on the platforms PubMed, Google Scholar, eLibrary.ru, CyberLeninka by keywords “paracetamol, acetaminophen, poisoning, epidemiology, hepatotoxicity, N-acetylcysteine”. Inclusion criteria: original, review articles, randomized and non-randomized clinical trials, meta-analyses and systematic reviews on the topic of paracetamol poisoning.Results and discussion. The literature review presents data on toxic effects, epidemiology, metabolism, and clinical picture; modern research on methods of diagnosis and treatment of paracetamol poisoning.Conclusions. Modern methods of diagnosing paracetamol poisoning allow us to focus not only on determining the concentration of the drug in the blood or the dose taken orally, as a decision-making tool. The development of new biomarkers of liver damage is a promising diagnostic tool, suggesting an “early warning” of potential liver damage.

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Парацетамол Среди Средств Суицидальных Действий В России И Зарубежом

Cited by 3 publications

References 48 publications

Paracetamol and ibuprofen in the treatment of pain and fever in children: modern views on the choice of a drug

Paracetamol and ibuprofen in the treatment of pain and fever in children: modern views on the choice of a drug

Acute Chemical Poisoning in an Industrial City: Current Situation, Dynamics and Forecast

Paracetamol Poisoning: Epidemiology, Diagnosis, Treatment (Status of the Issue)

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