One of the main branches of agricultural production in Ukraine was and remains animal husbandry. Under modern conditions of cattle breeding, the hooves of cows deserve special attention of a veterinarian, which are often exposed to various adverse factors, which, for the most part, leads to the development of inflammatory processes in the area of the base of the sole skin, sometimes of septic genesis complicated by keratomycetes. It is known that for the treatment of orthopedically ill animals there is enough wide arsenal of medicinal substances and developed methods of therapy, however, most of the proposed means exhibit only antibacterial properties, act in the lesions superficially, poorly penetrate into the depths of the tissues and do not always give the desired result. Therefore, the aim of the work was to develop an effective method of treatment of such animals with the use of medicinal substances with a wide range of antibacterial, antimycotic action, which have the ability to penetrate into tissues and promote their regeneration. For research, two groups of cows were formed, 5 animals in each, selected on the principle of analogues in terms of the nature and location of the pathological process. For therapeutic purposes, the cows of both groups after anesthesia were corrective clearing, formed a funnel-shaped hole in the area of purulent pododermatitis and irrigated with 10 % hypertonic sodium chloride solution. On the affected area, the animals of the control group was applied a finely grated (separately) mixture of potassium permanganate and boric acid, and the control – a mixture of nanoclusters of aquachelates Ag, Cu, Zn, impregnated with a cotton swab and pantevenoli. A bandage and a protective cover were applied to the affected hooves of animals of both groups. It is defined that the proposed method of treatment makes it possible to promote the recovery of animals and reduce the treatment period by 6 days, confirmed by the results of clinical, biochemical, bacteriological, mycological and statistical studies.