Прогнозирование Развития Рецидива После Эффективной Химиотерапии У Больных Туберкулезом С Множественной Лекарственной Устойчивостью Микобактерии Туберкулеза, "Вестник Центрального Научно-Исследовательского Института Туберкулеза"

Аллилуев, А. С.; Шнайдер, Е.Е.; Vrazhnov, Denis A.; Филинюк, О. В.

doi:10.7868/s2587667820050350

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…В Санкт-Петербурге были изучены отдаленные результаты оперативного лечения 187 больных ТБ легких с широкой лекарственной устойчивостью (ШЛУ). Суммарная частота послеоперационных рецидивов составила 10,6%: у пациентов с массивным бактериовыделением -22,5%, при его отсутствии -5,3% [27][28][29].…”

Section: туберкулезunclassified

Long-term results of treatment of patients with newly detected pulmonary tuberculosis

Pavlova,

Lushina,

Anisimova

et al. 2023

Medicinskij sovet

View full text Add to dashboard Cite

Introduction. The article is devoted to the effectiveness of the treatment of pulmonary tuberculosis with multiple (MDR) and broad drug resistance (XDR) M. tuberculosis (MBT) in patients after the end of the main course of treatment (intensive and continuation phase), which were observed with clinical cure in 3rd dispensary registration group.Aim. To study the long-term results of treatment of newly diagnosed patients with pulmonary tuberculosis with MDR and XDR MBT with the determination of significant risk factors for relapse in a megalopolis.Materials and methods. The main course of treatment was completed by 119 newly diagnosed patients with pulmonary tuberculosis with MDR or XDR TB for the period from 2013 to 2019, who were treated in anti-tuberculosis hospitals in St. Petersburg and outpatient in St. Petersburg Interdistrict Petrograd-Primorsky TB Dispensary No. 3. The patients were divided into two groups: the main group (MG) consisted of 40 people who received treatment regimens that included drugs (thioureidoiminomethylpyridinium perchlorate (perchlosone, bedaquiline, linezolid ), the control group (CG) – 79 people who received who received standard therapy, without the above drugs. The groups are comparable in clinical, radiological and bacteriological characteristics. The course of treatment was found effective in 86 (72.3%): in MG – in 34 (85.0%) people, in CG – in 52 (65.8%) people, p < 0.01. These 86 patients were transferred to the 3rd group of dispensary registration with a diagnosis of “clinical cure”.Results. Adverse treatment outcomes were analyzed, including the causes of tuberculosis recurrence. The use of drugs (perchlosone, bedaquiline, linezolid) in the complex chemotherapy of tuberculosis with MDR and XDR MBT increases the effectiveness of treatment of patients and significantly less often they have a recurrence of pulmonary tuberculosis (12.5%), compared with the group without the use of these drugs (27.8%). The most significant risk factors for relapses of drug-resistant tuberculosis: the preservation of residual cavities in the absence of bacterial excretion at the end of the main c male gender, concomitant pathology (HIV infection), past incarceration, late detection of the disease and destructive forms of tuberculosis.Conclusions. The main course of therapy was found to be effective in 86 (72.3%) in patients with MG – in 34 (85.0%) people, in CG – in 52 (65.8%) people, p < 0.01. All the patients who completed the course of therapy were transferred to the 3rd group of dispensary registration with a diagnosis of “clinical cure”. Relapses of the disease occurred much less frequently in patients receiving perchlozon, bedaquiline, linezolid in complex therapy compared with the control group.

show abstract

Section: туберкулезunclassified

Long-term results of treatment of patients with newly detected pulmonary tuberculosis

Pavlova,

Lushina,

Anisimova

et al. 2023

Medicinskij sovet

View full text Add to dashboard Cite

show abstract

Cited by 1 publication

References 0 publications

Long-term results of treatment of patients with newly detected pulmonary tuberculosis

Long-term results of treatment of patients with newly detected pulmonary tuberculosis

Contact Info

Product

Resources

About