The article highlights the importance of individual adaptability aligned with mental health in the workplace. Levels of employees’ personal adaptability were examined and described. The study revealed a set of diagnostic indicators that can indirectly indicate mental health, namely satisfaction with work and its components, levels of emotional burnout and general psychological well-being. The performed correlation analysis indicated positive links between the parameters of adaptability (mental stability, communication and moral norms) and key markers of psychological well-being and job satisfaction (achievements at work, relationships with employees, the level of professional aspirations and professional responsibility). The findings also suggested negative correlations between adoptability and most symptoms of burnout. The mental health of workers with high and normal adaptability was characterized by good professional well-being, interest in work, wide professional responsibilities, professional “inclusion”, emotional and communicative activity, and, at the same time, however, a tendency to burnout; employees with satisfactory adaptability demonstrated emotional burnout, disintegrated psychological well-being, immature professional communications, emotional dissatisfaction with work, dissatisfaction with themselves, emotional and professional helplessness and conformism; employees with low adaptability demonstrated communicative-emotional suggestibility, professional-existential burnout, emotional resistance, external locus of control, integral dissatisfaction with work, emotional exhaustion and emotional-communicative frustration.