Роль Холінергічного Дефіциту В Патогенезі Психоневрологічних Захворювань

Дзяк, Л. А.; Tsurkalenko, O.S.

doi:10.22141/2224-0713.3.105.2019.169917

Cited by 3 publications

(1 citation statement)

References 46 publications

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“…However, data on changes in cholinergic systems of the central nervous system following the exposure to manganese are considerably less extensive (Koroleva, 2023). The high representation of cholinergic neurons in brain structures that play a key role in the formation of cognitive functions determines the critical importance of cholinergic transmission for memory, learning, and attention (Dziak, and Tsurkalenko, 2019). In this connection, we assessed the content in the blood serum of one of the most important enzymes of the cholinergic system -acetylcholinesterase.…”

Section: Discussionmentioning

confidence: 99%

Influence of subchronic exposure to manganese carried by female rats during pregnancy on the behavioral and cognitive abilities of their offspring at later stages of postnatal development

Kazakova,

Marshinskaya,

Notova

2024

BioComm

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The study evaluated the effects of prenatal exposure to manganese (Mn) on the functional state of offspring at later stages of postnatal development (PND). Female rats were treated with MnSO4·5H2O in the diet at a dose of 1433 mg/kg starting 28 days prior to breeding and through gestation. The pregnancy proceeded normally, no physical abnormalities were observed. There was a lag in physical development of the offspring, which was characterized by a later opening of the eyes, the formation of a coat and the eruption of incisors, the weight gain was attenuated from PND 0-84. Offspring had hyperactive behavior and deterioration in spatial learning and memory. The level of Mn in the blood serum and cerebral cortex was higher than the control values by 11 % and 53 % respectively. The acetylcholinesterase level in the serum was higher by 47 %. These findings highlight the risk of prenatal exposure to subchronic doses of Mn.

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Section: Discussionmentioning

confidence: 99%

Influence of subchronic exposure to manganese carried by female rats during pregnancy on the behavioral and cognitive abilities of their offspring at later stages of postnatal development

Kazakova,

Marshinskaya,

Notova

2024

BioComm

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A personalized selection of choline precursors in evidence — based medicine

Путилина¹

2020

Z. nevrol. psikhiatr. im. S.S. Korsakova

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Influence of phytocomposition with nootropic properties on cognitive functions of the human brain

Filatova,

Mamishev,

Voronina

et al. 2024

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Objective: To study the effect of a phytocomposition with nootropic properties on the cognitive functions of the human brain.Materials and methods. Conditionally healthy volunteers of both sexes over the age of 45 took part in the study. The function of attention was studied using the Bourdon correction test. The short-term memory function was assessed using the tasks “Memorizing 10 numbers”, “Memorizing 10 words”. Logical thinking was assessed using the Complex Analogies test.Results. The parameters of the attention function such as productivity, accuracy of attention, integrative indicator of stability of attention, coefficient of mental productivity, mental performance, and level of concentration increased significantly in the group of people took phytocomposition. The ability to find logical connections between words pairs increased according to the results of the test. The effect of the phytocomposition was more pronounced, the lower the initial indicators were.Conclusion. The phytocomposition “Memoris” has a positive effect on cognitive functions (attention, thinking).

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Роль Холінергічного Дефіциту В Патогенезі Психоневрологічних Захворювань

Cited by 3 publications

References 46 publications

Influence of subchronic exposure to manganese carried by female rats during pregnancy on the behavioral and cognitive abilities of their offspring at later stages of postnatal development

Influence of subchronic exposure to manganese carried by female rats during pregnancy on the behavioral and cognitive abilities of their offspring at later stages of postnatal development

A personalized selection of choline precursors in evidence — based medicine

Influence of phytocomposition with nootropic properties on cognitive functions of the human brain

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