Роль Імунної Системи У Механізмі Терапевтичної Дії Метформіну У Хворих На Цукровий Діабет 2-Го Типу

Abstract

Abstract. Background. Metformin is one of the most prescribed hypoglycemic drugs of the first line of treatment for patients with type 2 diabetes (T2D

Порівняльна Характеристика Активності Протеолізу За Умов Експериментального Перитоніту Та Його Розвитку На Тлі Цукрового Діабету

“…The activation of proteolytic transformation of kinins may be of regulatory nature. One cannot deny that imbalance between kinin activity dilating the vessels, and angiotensin, which causes vasoconstriction, stimulates the development of circulatory disorders that are common for DM [1,8]; in addition, the disorders intensify kininase, which converts angiotensin І to angiotensin ІІ [16]. The role of kinins in the realization of the inflammation program is shown [9], their proteolytic transformation is enhanced by one of the factors, which modify the course of inflammation in the peritoneal cavity in AP developing against the background of DM.…”

“…The collagenolysis activation in group 2 can be interpreted from diffe rent points of view. On the one hand, this could be due to some need for extra-influence on the vessel walls as their structure changes in DM [1]. On the other hand, increased collagenolysis could be one of the additional factors for activation of cells of the monocyte-macrophage system and lymphocytes taking into consideration the chemoattractant and cytoimmunoregulatory properties of the proteolytic transformation of collagen products [19].…”

“…The incidence of diabetes mellitus (DM) is constantly growing all over the world in recent years [1][2][3]. That is why the number of patients with acute peritonitis (AP) which is common [4][5][6] is growing that is associated with DM.…”