Сorrelation between the level of 25(OH)D3 in blood, the content of antimicrobial peptides in oral fluid and dental caries intensity in young individuals

Putneva, A.S.; Mishchenko, M.N.; Karavaeva, T.M.; Mudrov, V.A.; Maksimenya, M.V.; Цыбиков, Н. Н.; Drozdova, A.M.

doi:10.20333/25000136-2022-2-62-68

Cited by 2 publications

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“…Subsequently, 29 publications were recognized as potentially relevant records. A comprehensive full-text screening resulted in the exclusion of 16 articles due to their failure to meet the eligible inclusion criteria, lack of sufficient data, or duplication of study content [16,17,[49][50][51][52][53][54][55][56][57][58][59][60][61][62] (Supplementary Table S2). As a result, the current systematic review and meta-analysis included a total of 13 cross-sectional studies.…”

Section: Literature Searchmentioning

confidence: 99%

Association between Vitamin D Levels and Dental Caries: A Systematic Review and Dose-Response Meta-Analysis of Cross-Sectional Studies

Mahmood,

Tassery,

Tardivo

et al. 2023

Applied Sciences

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Background and Aims: Previous observational studies found inconsistent associations between serum vitamin D levels and dental caries risk. A dose-response meta-analysis of cross-sectional studies was performed to investigate the association. Methods: To April 2023, the ISI Web of Science, PubMed, Scopus, and Google Scholar databases were searched for published papers. Finally, 13 cross-sectional studies were considered that provided odds ratios (ORs) with 95% confidence intervals (CIs) for dental caries in relation to serum vitamin D levels across all age groups. Two reviewers conducted a thorough screening of the studies, data extraction, bias risk assessment, and evidence quality. A random-effect model was used to assess the pooled estimated odd ratios (with 95% confidence intervals). A weighted mixed-effects dose-response meta-analysis in one stage was carried out. Results: Dental caries was significantly more likely to occur when serum vitamin D levels were low compared to high (OR: 1.41; 95% CI: 1.18, 1.68; GRADE = poor confidence). With a 10 nmol/L increase in serum vitamin D level, linear dose-response analysis showed a significant 3% (OR: 0.97; 95% CI: 0.96, 0.99) decrease in the likelihood of dental caries. Serum vitamin D levels and dental caries were found to be inversely correlated, with a significant dose-response relationship at levels greater than 78 nmol/L. Conclusion: This meta-analysis showed that vitamin D insufficiency was strongly associated with dental caries, and that a 10 nmol/L increase in blood 25(OH)D levels was linked to a 3% decrease in dental caries. However, the findings may have less clinical significance due to the uncertainty of the evidence.

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Section: Literature Searchmentioning

confidence: 99%

Association between Vitamin D Levels and Dental Caries: A Systematic Review and Dose-Response Meta-Analysis of Cross-Sectional Studies

Mahmood,

Tassery,

Tardivo

et al. 2023

Applied Sciences

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The influence of professional oral hygiene on the indicators of local immunity

Reshetnyova,

Rukosueva,

Afanas’eva

et al. 2024

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Professional oral hygiene is an important part of measures aimed at preventing and maintaining the patient’s health. Local immune response is the first barrier of immune protection capable of preventing infection diseases. The aim of the study - the influence of professional hygiene on the indicators of local immunity has been studied. The study involved two groups of patients: the first group included 19 individuals with chronic caries of varying depths (class I), and the second group comprised 15 individuals with moderate periodontal disease. To evaluate nonspecific oral protection, the index of natural colonization of the buccal epithelium and the activity of microbial adsorption by oral mucosal cells were assessed. Specific immunity was evaluated by measuring the concentration of immunoglobulins in unstimulated saliva. All indicators were recorded both before and after professional oral hygiene procedures. When studying the index of natural colonization of the buccal epithelium, it was found that professional cleaning in both groups led to normalization of the spectrum of bacteria adhered to the epithelium: there was a decrease in the amount of gram-negative microflora, atypical for this biotope, while maintaining a high adhesion index of gram-positive cocci. In persons with caries, before sanation, “unsatisfactory” resistance of oral mucosa was revealed in a third of the examined, after sanation, the number of such patients decreased by 3 times, with “satisfactory” resistance increased by 2 times. In the group with periodontal disease, all patients exhibited “unsatisfactory” mucosal resistance before the hygiene procedures. After sanitation, 20 % “unsatisfactory” resistance persisted. In the majority of patients (80 %), the resistance of the oral mucosa improved to “satisfactory”. The concentration of all classes of immunoglobulins in both groups before sanitation was significantly below the norm, after the measures taken, the indicators increased significantly and reached the level typical for healthy individuals. Carrying out professional cleaning of the teeth leads to the normalization of local immune status even without additional medical immunocorrection.

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Сorrelation between the level of 25(OH)D3 in blood, the content of antimicrobial peptides in oral fluid and dental caries intensity in young individuals

Cited by 2 publications

References 0 publications

Association between Vitamin D Levels and Dental Caries: A Systematic Review and Dose-Response Meta-Analysis of Cross-Sectional Studies

Association between Vitamin D Levels and Dental Caries: A Systematic Review and Dose-Response Meta-Analysis of Cross-Sectional Studies

The influence of professional oral hygiene on the indicators of local immunity

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