In this article, the author continues research in the field of technological development of industrial regions of the Russian Federation. This study expands the author’s methodology for diagnosing the technological development of industrial regions. The purpose of the study is to diagnose material, labor and investment factors in the development of traditional and high-tech sectors of the economy of industrial regions. Based on the diagnostics carried out, the identification of risk factors for the technological development of industrial regions is identified. For the purpose of diagnosing and assessing the factors of technological development, the author has developed a research methodology in relation to the industrial regions of the Russian Federation, including: 1) Development of a system of indicators characterizing the factors of technological development of the industrial regions of the Russian Federation. Grouping of factors of technological development of industrial regions into three groups: material, labor and investment. Dividing the factors of technological development into two sectors of the economy: traditional and high-tech. 2) Analysis of the values of statistical indicators of factors of technological development of industrial regions of the Russian Federation. 3) Point-rating assessment of factors, which is carried out on a scale from -2 to 2. 4) Analysis of factors of technological development of industrial regions of the Russian Federation with values below the average for the Russian Federation for 2018-2022. 5) Grouping of industrial regions into risk zones, which was carried out on the basis of an analysis of scientific literature and diagnostics of factors of technological development. 6) Development of directions for neutralizing risk factors identified during the diagnostic process in the traditional and high-tech sectors of the economy. Research tools include: economic analysis, factor analysis, statistical analysis, comparative analysis, scoring.