Современные Этиологические И патогенетические Аспекты Воспалительнодеструктивных Процессов Тканей Пародонта

Ушницкий, И. Д.; Ivanova, Angelina A.; Пинелис, И. С.; Юркевич, А. В.; Михальченко, Д В

doi:10.36377/1683-2981-2019-17-4-46-49

Cited by 4 publications

(1 citation statement)

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“…В ходе современных научных исследований получены комплексные сведения о механизмах клеточных реакций в условиях физиологического, репаративного и патологического ремоделирования тканей пародонта в сравнительном аспекте [3,4]. Дополнены уже имеющиеся и углублены существующие знания об иммунопатогенезе ХГП [5,6].…”

Section: Introductionunclassified

Index Evaluation of Clinical Efficacy of Immunomodulatory and Osteotropic Therapy for Chronic Generalized Periodontitis of Varying Severity: A Prospective Cohort Study

Bykova,

Sirak,

Ovsyannikova

et al. 2023

Kuban. nauсh. med. vestnik

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Background. The significant prevalence of chronic generalized periodontitis, the severity of its course, the increase in the number of complicated forms and short-term remissions cause a constant search for new methods and means of its treatment. When choosing the most effective methods of therapy, specialists mostly prefer a complex effect on the main pathogenetic links of the disease, while often losing sight of the body's own defenses, especially in terms of pharmacotherapeutic support and immunity strengthening. This study presents the results of a study of the clinical efficacy of the treatment of chronic generalized periodontitis by means of the developed therapy complex, including the use of immunomodulatory and osteotropic drugs.Objective — to study clinical efficacy of the developed complex immunomodulatory and osteotropic treatment for chronic generalized periodontitis.Methods. A prospective cohort study was conducted in 154 patients aged 20 to 75 with periodontitis of varying severity. Conventional examination of patients was carried out in specialized dental clinics DentoProma (Krasnodar) and Dentalife (Stavropol) based at the Dentistry Department, Stavropol State Medical University (Russia). The study period was 24 months. The patients were divided into a main group of 118 participants and a control group of 36 participants. The comprehensive treatment plan, prescribed to all patients, included proper oral hygiene education, individual and professional dental hygiene, topical anti-inflammatory agents, Vector therapy, open flap debridement, flap surgery, relevant splinting prosthetics (if necessary). The authors developed a comprehensive therapy, which included administration of the immunomodulatory agent Hepon (Immapharma Company, Russia), glucosamine hydrochloride and chondroitin sulfate sodium. All patients of the main and control groups were additionally ranked into subgroups depending on the severity of diagnosed periodontitis: slight (subgroup 1), moderate (subgroup 2) and severe (subgroup 3). The major focus of the study was to establish efficacy of the developed therapy which was defined by the degree of resolution of the inflammatory process and increase in the period of remission. Reflecting the presence and degree of inflammation, dental plaque index and oral hygiene status were considered to be the target indicators. Analysis and statistical processing of the obtained data were carried out using Microsoft Excel (Microsoft, USA).Results. The analysis of the data revealed that the immediate clinical results of the developed complex therapy both in the main group and in the control group were approximately identical. According to the follow-up data obtained one month after the treatment, additional prescription of complex osteotropic treatment to the patients with chronic generalized periodontitis contributed to rapid resolution of infection in the gingival tissues and provided stable treatment results.Conclusion. Introduction of the complex clinical and hygienic treatment promoted resolution of the inflammatory process in the gingival tissues of all patients who received immunomodulatory and osteotropic therapy.

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Section: Introductionunclassified

Index Evaluation of Clinical Efficacy of Immunomodulatory and Osteotropic Therapy for Chronic Generalized Periodontitis of Varying Severity: A Prospective Cohort Study

Bykova,

Sirak,

Ovsyannikova

et al. 2023

Kuban. nauсh. med. vestnik

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Evaluation of the Clinical Effectiveness of Toothpaste Containing Grapefruit Extract and Lysotech and Protelyse Lysates in the Complex Treatment of Inflammatory Periodontal Diseases

Токмакова

Бондаренко

Lunitsyna

2021

Actual Problems in Dentistry

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The preventive direction in dentistry is the leading one today. Individual oral hygiene plays a significant role in preventing the development of inflammatory periodontal diseases. The use of therapeutic and prophylactic toothpastes containing natural components with antibacterial properties is promising. Among plant extracts, grapefruit extract has the most pronounced antimicrobial activity. LysoTech and ProteLyse lysates, which have antimicrobial and immunomodulatory effects, have long been used in dentistry in the form of tablets for resorption in the complex treatment of various diseases. Their introduction into toothpastes is also considered a promising direction for the prevention and treatment of oral pathology. The aim of our study was to clinically evaluate the effectiveness of therapeutic and prophylactic toothpaste, which contains grapefruit extract and LysoTech and ProteLyse lysates, in patients with inflammatory diseases of periodontal tissues. A clinical and laboratory comparative study of two therapeutic and prophylactic toothpastes was conducted. The composition of the samples was identical, except for two components: grapefruit extract and LysoTech and ProteLyse lysates. The study involved 60 volunteers who were divided into two groups depending on the toothpastes used. The purifying and anti-inflammatory effects of the samples were evaluated for one month. An in vitro laboratory study was also conducted to identify the antimicrobial properties of toothpastes. During the work, high clinical results were noted in a group of volunteers using toothpaste with grapefruit seed extract and bacterial lysates, which are expressed in a decrease in PMA and SBI indices, and an improvement in oral hygiene. According to a laboratory study, the toothpaste containing grapefruit extract and LysoTech and ProteLyse lysates has a more pronounced antimicrobial and antifungal effect, which indicates a high preventive and therapeutic potential of the test sample.

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Treatment of aggressive (rapidly progressing) generalized periodontitis using systemic enzyme therapy in combination with osteoinductive medicines

Gudaryan¹,

Мащенко²,

Kucherenko³

2020

Medicni Perspektivi (Medical Perspectives)

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Современные Этиологические И патогенетические Аспекты Воспалительнодеструктивных Процессов Тканей Пародонта

Cited by 4 publications

References 0 publications

Index Evaluation of Clinical Efficacy of Immunomodulatory and Osteotropic Therapy for Chronic Generalized Periodontitis of Varying Severity: A Prospective Cohort Study

Index Evaluation of Clinical Efficacy of Immunomodulatory and Osteotropic Therapy for Chronic Generalized Periodontitis of Varying Severity: A Prospective Cohort Study

Evaluation of the Clinical Effectiveness of Toothpaste Containing Grapefruit Extract and Lysotech and Protelyse Lysates in the Complex Treatment of Inflammatory Periodontal Diseases

Treatment of aggressive (rapidly progressing) generalized periodontitis using systemic enzyme therapy in combination with osteoinductive medicines

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