To date, the study of the relationship between the intestinal microbiome and COVID-19 infection remains a topical issue. As is known, the gastrointestinal tract is the entrance gate for SARS-CoV2 infection, and the prevalence of gastrointestinal manifestations reaches 17,6%. The conducted studies testify in favor of changes in the composition of the intestinal microflora in patients with COVID-19 compared with patients without a respiratory infection, their influence on the course and prognosis of the disease is being studied.