Третинний Перитоніт Як Проблема Абдомінальної Хірургії

Fomin, P D; Matviychuk, Oleh

doi:10.26779/2522-1396.2018.01.49

Cited by 4 publications

(4 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In 15-25 %, the course of urgent surgical diseases is complicated by peritonitis. Mortality in common forms of peritonitis, according to different authors, ranges from 10 to 60 %, and in hospital peritonitis it can reach 90 % [1,2,3].…”

Section: Introductionmentioning

confidence: 99%

“…However, in case of untimely correction, some cytokines (TNF-α, IL-1, IL-6, IL-10) can penetrate into the systemic circulation and accumulate there in quantities sufficient for the ОРИГІНАЛЬНІ ДОСЛІДЖЕННЯ implementation of damaging effects. In the case of the inability of regulatory systems to maintain homeostasis, the destructive effects of cytokines and other mediators begin to dominate, which leads to impaired permeability and function of the capillary endothelium, triggered disseminated intravascular coagulation syndrome, the formation of distant foci of systemic inflammation, the development of mono-and multiorgan dysfunction [1,3,4,5,6].…”

Section: Introductionmentioning

confidence: 99%

“…Traditionally, intensive therapy of peritonitis includes full surgical debridement of the infection site, adequate antimicrobial and detoxification therapy. At the same time, maintaining the patient's life, preventing and eliminating organ dysfunction is impossible without targeted immunocorrection [1,11].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Prevention of Early Postoperative Complications of Intestinal Surgery Using Immunomodulating Therapy

Tymchenko¹

2020

Khark. Surg. Sch.

View full text Add to dashboard Cite

Summary. The aim of the study is to develop a method of immunocorrection, which improves the results of treatment of patients with developed peritonitis against the background of the small intestine anastomosis leakege by stopping the cascade of SIRS and MOF. Materials and methods. The work was clinical in nature, was performed in the clinic of the SI «ZIGUS NAMSU» in the period from 2016 to 2019. We examined 58 patients with various diseases of the abdominal organs complicated by peritonitis, in which sections of the small intestine were resected. The Comparison Group included patients who received traditional therapy, patients of the Main Group, the complex of drug therapy included recombinant interleukin-2, galavit and α-lipoic acid. The results of surgical treatment were evaluated according to the classification of D. Dindo, N. Demartinesta, P.-A. Clavien (2004). Statistical analysis was removed from the Statistica 6.0 software (StatSoft, Inc. 2001) and SPSS 7.5 on Apple PC. Results and Discussion. Thus, the results of the use of a comprehensive immunomodulation scheme using IL-2, galavit and α-lipoic acid in the complex treatment of patients with widespread peritonitis against the background of intestinal anastomosis failure suggest that the developed scheme has a targeted immunoregulatory effect and prevents the excess production of inflammatory mediators in the early postoperative the period of the disease, helps to eliminate the cytokine imbalance and prevents the development of secondary immune deficiency. A comparative analysis of the incidence of complications revealed that in patients of the Main Group the average number of complications per patient was 0.53, while in the Comparison Group this indicator was 1.36. Conclusions. The use of a combination of IL-2, galavit and α-lipoic acid in the complex of treatment of common peritonitis helps to reduce the level of systemic and local postoperative complications, as well as the level of postoperative mortality.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Prevention of Early Postoperative Complications of Intestinal Surgery Using Immunomodulating Therapy

Tymchenko¹

2020

Khark. Surg. Sch.

View full text Add to dashboard Cite

show abstract

“…It is known that the leading pathophysiological aspect in patients with failure of intestinal anastomoses are volemic and hemodynamic disorders, which are due to reduced arterial inflow and impaired venous outflow due to compression of intramural vessels, sequestration of fluid into the intestinal lumen and abdominal cavity [1,2]. DOI:https://doi.org/10.37699/2308-7005.…”

Section: Introductionmentioning

confidence: 99%

The Use of Biotechnology in the Prevention of Failure in the Imposition of Small Intestinal Anastomoses in the Experiment

Tymchenko¹,

Ivanova²,

Padalko³

et al. 2020

Khark. Surg. Sch.

View full text Add to dashboard Cite

Summary. The aimof the study is to develop a method of sealing the sutured of the small intestine anastomosis in conditions of high risk anastomosis leakege by stopping the inflammation’ cascade in experiment. Materials and methods.The work was experimental in nature, was performed in the SI «ZIGUS NAMSU» in collaboration with the Scientific Research Institute of Biology V. N. Karazin KhNU in the period from 2018 to 2019. To increase the tightness of the intestinal anastomoses applied under conditions of laparatomy, experimental studies were conducted on laboratory animals. The studies were carried out after the permission of the ethics committee SI «ZIGUS NAMSU» in compliance with all ethical requirements for the humane treatment of animals.Surgical operations in two series of experiments were performed under operating conditions under general anesthesia on 10 white sexually mature linear rats – Wistar males, 12-18 months old, weighing about 250 grams. All morphological material (the first and second series of experiments) was marked and fixed in a 10% solution of neutral formalin. Subsequently, paraffin sections were prepared according to the generally accepted histotechnical method and stained with hematoxylin - eosin; according to Van Gieson and Mallory, an immunohistochemical study was used to study microenvironment factors. Results and Discussion. Immunohistochemical examination of the intestine was carried out in several stages, at the first stage we took intestinal tissue during the surgery to form the intestinal anastomosis, before the introduction of allogeneic cell transplants. Also carried out immunohistochemical studies of the emerging mucous membrane at various times after the formation of insolvency of intestinal anastomoses in both studied groups. When using a cell allograft, the mechanisms of repair of the intestinal mucosa include the appearance of cells that carry the expression of markers of mesenchymal and epithelial differentiation (Vim, CD34, CKW, Ecad), and are usually localized in the walls of blood vessels of granulation tissue, as well as in areas of the repairing epithelium. In addition, in the main group, only 7 days after the reaction to cytokeratins (CKW) and Ecad, areas of the repairing epithelium were detected, while the visualization of the epithelium in the control group did not begin even after 10 days. The analysis of immunophenotypes of repairing cells allows us to suggest the participation of mesenchymal-epithelial transformation mechanisms in this process. Conclusions.Thus, studies have shown that the use of cell transplantation of culture of allogeneic cells of the intestine leads to the reconstruction of the intestinal mucosa in a fairly short time. Conducted histological and immunohistochemical studies showed that in the vast majority of animals (77.2%) 10-14 days after the operation, an almost unchanged mucous membrane forms with the preservation of its elasticity.

show abstract

Microbiological aspects of peritonitis

Karol

2022

View full text Add to dashboard Cite

Objective. To investigate pathogens in peritonitis. Materials and methods. In 2021 yr in Department of Surgery of Brovary Multidisciplinary Clinical Hospital were treated 360 patients with an acute peritonitis of various genesis: 186 (51.7%) women and 174 (48.3%) men. Results. In the patients 391 strains of microorganisms, which are optionally-anaerobic and aerobic of Gram-negative and Gram-positive pathogens were isolated: Escherichia coli – in 144 (36.8%), Streptococcus spp. – 52 (13.3%), Enterococcus faecalis – 47 (12.0%), Staphylococcus aureus – 37 (9.5%), Klebsiella pneumoniae – 31 (7.9%), Citrobacter – 25 (6.4%), Staphylococcus haemolyticus – 23 (5.9%), Pseudomonas aeruginosa – 14 (3.6%), Acinetobacter baumannii – 13 (3.3%), and Proteus mirabilis – 5 (1.3%) strains. Conclusion. Majority of microorganisms, isolated in patients, suffering peritonitis, was characterized by significant antibiotic resistance. Most frequently Escherichia coli was sowed – 36.8%. All strains of Escherichia coli isolated were resistant to vancomycine, clindamycine and linezolide.

show abstract

Третинний Перитоніт Як Проблема Абдомінальної Хірургії

Cited by 4 publications

References 0 publications

Prevention of Early Postoperative Complications of Intestinal Surgery Using Immunomodulating Therapy

Prevention of Early Postoperative Complications of Intestinal Surgery Using Immunomodulating Therapy

The Use of Biotechnology in the Prevention of Failure in the Imposition of Small Intestinal Anastomoses in the Experiment

Microbiological aspects of peritonitis

Contact Info

Product

Resources

About