Based on the analysis of specialized literature, normative and legislative acts, as well as data from own research, the medical and legal aspects of the divergences between clinical and anatomopathological diagnosis are presented. Thus, through the analysis of the archive materials of Institute of Phthisiopneumology «Chiril Draganiuc» it was established that the percentage of autopsies in the period 2013-2022 varied between 68.5% and 94.4%. Having a stable growth trend (R2=0.7542), this indicator averaged 83.7%. The percentage of diagnostic discrepancies during this period ranged from 7.0% to 24.5%, with a mean of 14.4%. The downward trend of this indicator from 24.5% in 2013 to 16.8% in 2022 was not conclusive (R2=0.3097).