早期帕金森病患者血清胆红素、尿酸及同型半胱氨酸水平的变化

Abstract

Objective: To investigate the changes of serum levels of uric acid (UA), indirect bilirubin (IBIL), homocysteine (Hcy) and the UA and Hcy ratio in patients with early Parkinson's disease (PD) accompanied by mild cognitive impairment (MCI), and explore the correlation between the above-mentioned indexes and the prediction of PD-MCI. Methods: A total of 158 patients with newly diagnosed drug-naive PD and 102 healthy participants were employed as the control in this study. Assessments of PD-related indexes included measures of motor disability (MDS-UPDRS), disease severity (Hoehn & Yahr staging) and global cognitive function (Montreal Cognitive Assessment, MoCA). Results: 71 patients (44.9%) in PD group were identified with MCI, and 87 patients (55.1%) presented no cognitive impairment (NCI). There is a significance difference in MoCA scales between PD-MCI group and PD-NCI group (P < 0.01). The serum IBIL level In PD group (8.28±2.59) μmol/L was significantly reduced than that in control group (9.23±2.33 μmol/L), P < 0.01, and the serum IBIL level in PD-MCI group (7.69±2.97 )μmol/L was significantly reduced than that in PD-NCI group (9.11±2.85 μmol/L, P < 0.01). The serum UA levels in PD group, PD-MCI group and PD-NCI group were significantly reduced than that in control group (P < 0.01). The PD-NCI group had a significantly increased level of UA than that in PD-MCI group (P<0.01). The serum Hcy level in PD-MCI group was significantly increased than that in control group as well as in PD-NCI group (P < 0.05, P < 0.05 respectively). Levels of IBIL, UA and UA to Hcy ratio were of good value in predicting PD-MCI. Moreover, the UA and Hcy ratio had a higher value than IBIL or UA for predicting MCI in early PD. Conclusion: The serum levels of IBIL and UA in patients with early PD were significantly induced than that in control group. The UA and Hcy ratio had a higher value than IBIL or UA for predicting MCI in early PD. The UA and Hcy ratio might be a potential biomarker for predicting PD-MCI.