晶癖を含めた結晶性医薬品の光学的結晶学的特性値一覧表作成の試み

Abstract

It was clariˆed in previous report that the predominant faces of crystal habits mainly coincide with the morphologic crystal face at (001), (010), or (100), and therefore the two measurable key refractive indices are closely related to the principal sections of the two axial wave surfaces and coincide with the one or two of the three principal refractive indices. The three principal refractive indices of biaxial crystalline drugs were measured and tabulated in the``General Information'' section of the National Formulary compiled by the American Pharmaceutical Association. A series of studies was conducted to measure the key refractive indices of the crystalline drugs listed in the Japanese Pharmacopoeia X or XI so that the data could be used to improve the quantitative analysis of their crystal habits. The purpose of the present study was to examine data on both the key and principal refractive indices and attempt to produce a general authorized table of optic crystallographic characteristics, including crystal habits, for simpler and more reliable polarizing microscopy studies.

Important Factors in the Size Reduction of Polymer-Stabilized Drug Particle Suspensions Using High-Pressure Homogenization

“…Samples were run for combined obscuration and polarization intensity differential scattering analysis. A refractive index of 1.672 was used for griseofulvin [15]. The unit was thoroughly rinsed between samples; acetone or isopropyl alcohol was used if cleaning was required.…”

Interaction Studies Between Indomethacin Nanocrystals and PEO/PPO Copolymer Stabilizers

“…The clear shift of 0.32°in the main SPR peak position corresponds to a mass areal density of~300 ng/cm 2 of indomethacin deposited on the sensor surface. Optical modeling of the SPR spectra shows that the thickness of the indomethacin layer deposited on the sensor slide was 1.5 nm when using 1.55 as the refractive index for indomethacin (28). The surface coverage and thickness of the indomethacin layer on the sensor surface is in the same range when comparing to self-assembled monolayers of thiolates on metal surfaces, which typically form 1-3 nm thick organic layers with a maximum surface coverage of 4.5×10 14 molecules/cm 2 (29).…”

Acoustic Anomalies and Fast Relaxation Dynamics of Amorphous Progesterone as Revealed by Brillouin Light Scattering

“…Figure 4 shows the temperature dependence of n V and α B / n . The average refractive index of progesterone single crystal is ~1.59 at room temperature [ 29 ]. If we assume this as the approximate refractive index of amorphous progesterone, the V and α B at T g are ~2400 m/s and ~8.73 × 10 5 m −1 , respectively.…”