树鼩&amp;mdash;&amp;mdash;作为一种新颖的非人灵长类实验疾病动物模型

肖吉,; Xiao, Jianru; 刘蓉,; 陈策实,; Liu, Rong; Chen, Ceshi

doi:10.24272/j.issn.2095-8137.2017.033

Cited by 46 publications

(21 citation statements)

References 100 publications

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“…As an experimental model, the tree shrew is smaller in size, easier to handle, less aggressive and less expensive in terms of the cost per animal than ferrets (approximately 1/10 of the price). Importantly, tree shrews are evolutionarily closer to humans and primates than ferrets are 19 , 21 .…”

Section: Discussionmentioning

confidence: 99%

“…The tree shrew ( Tupaia belangeri , family Tupaiidae), indigenous to South Asia, Southeast Asia, and Southwest China, is classified as a separate taxonomic group of mammals that diverged from the primate order approximately 85 million years ago but still be considered as a “low-level primate” based on their close relationship 19 . Tree shrew is phylogenetically more closely related to humans than ferret and mice.…”

Section: Introductionmentioning

confidence: 99%

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Tree shrew as a new animal model to study the pathogenesis of avian influenza (H9N2) virus infection

Yuan

Xia

et al. 2018

Emerging Microbes & Infections

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Outbreaks of avian influenza virus continue to pose threats to human health. Animal models such as the mouse, ferret, and macaque are used to understand the pathogenesis of avian influenza virus infection in humans. We previously reported that the tree shrew (Tupaia belangeri, family Tupaiidae), which is regarded as a “low-level primate”, has α2,3- and α2,6-linked sialic acid receptor distributions similar to those of humans and is potentially a useful mammalian model for studying mild human influenza (H1N1) virus infection. In this study, we used the tree shrew experimental model to investigate the pathogenesis of avian influenza A (H9N2) virus infection and the effect of the E627K mutation in the PB2 gene, an adaptation to mammalian hosts. Evidence of disease, virus titers in the upper and lower respiratory tract, histopathology and induction of proinflammatory cytokines are described. We also established ex vivo culture models of tree shrew respiratory tissues to study the tropism and replication of the H9N2 virus. Our results demonstrated that the tree shrew is a viable new in vivo experimental model for avian influenza research that provides results comparable to those observed in ferrets. The disease spectrum and pathogenesis in tree shrews correlate well with what is observed in humans.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Tree shrew as a new animal model to study the pathogenesis of avian influenza (H9N2) virus infection

Yuan

Xia

et al. 2018

Emerging Microbes & Infections

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“…There have been many studies looking at the effect of Humanin in disease, in particular in AD, which have used animal models, and the results obtained from studies may well have been affected by whether the animals had functional copies of the Humanin gene, or pseudogenes. Also, research to find new animal models for many diseases is an important field ( Xiao et al, 2017 ; Yao, 2017 ), and it would now seem that sequencing of the mtDNA, and in particular the Humanin gene, should become routine in any animal under consideration.…”

Section: Discussionmentioning

confidence: 99%

Humanin基因的假基因化普遍存在于若干脊椎动物的线粒体DNA中

Logan¹

2017

Zool. Res.

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In the human the peptide Humanin is produced from the small Humanin gene which is embedded as a gene-within-a-gene in the 16S ribosomal molecule of the mitochondrial DNA (mtDNA). The peptide itself appears to be significant in the prevention of cell death in many tissues and improve cognition in animal models. By using simple data mining techniques, it is possible to show that 99.4% of the human Humanin sequences in the GenBank database are unaffected by mutations. However, in other vertebrates, pseudogenization of the Humanin gene is a common feature; occurring apparently randomly in some species and not others. The persistence, or loss, of a functional Humanin gene may be an important factor in laboratory animals, especially if they are being used as animal models in studies of Alzheimer's disease (AD). The exact reason why Humanin underwent pseudogenization in some vertebrate species during their evolution remains to be determined. This study was originally planned to review the available information about Humanin and it was a surprise to be able to show that pseudogenization has occurred in a gene in the mtDNA and is not restricted solely to chromosomal genes.

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“…Chimpanzees are the only non-human primate fully susceptible to HBV infection, though their use in HBV research is strongly restricted ( Wieland, 2015 ). Several non-primate species can be infected with HBV, including the tree shrew ( Tupaia belangeri ), which also exhibits a close phylogenetic relationship with primates ( Xiao et al, 2017 ). In addition, primary Tupaia hepatocytes are suitable for HBV study, with sodium taurocholate co-transporting polypeptide (NTCP) recently identified using this system ( Yan et al, 2012 ).…”

Section: Introductionmentioning

confidence: 99%

Hbv研究常用的动物模型

Guo

Zhu

et al. 2018

Zool. Res.

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Even with an effective vaccine, an estimated 240 million people are chronically infected with hepatitis B virus (HBV) worldwide. Current antiviral therapies, including interferon and nucleot(s)ide analogues, rarely cure chronic hepatitis B. Animal models are very crucial for understanding the pathogenesis of chronic hepatitis B and developing new therapeutic drugs or strategies. HBV can only infect humans and chimpanzees, with the use of chimpanzees in HBV research strongly restricted. Thus, most advances in HBV research have been gained using mouse models with HBV replication or infection or models with HBV-related hepadnaviral infection. This review summarizes the animal models currently available for the study of HBV infection.

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树鼩——作为一种新颖的非人灵长类实验疾病动物模型

Cited by 46 publications

References 100 publications

Tree shrew as a new animal model to study the pathogenesis of avian influenza (H9N2) virus infection

Tree shrew as a new animal model to study the pathogenesis of avian influenza (H9N2) virus infection

Humanin基因的假基因化普遍存在于若干脊椎动物的线粒体DNA中

Hbv研究常用的动物模型

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