A pertinent issue in the administration of pneumonic contaminations is the low explicitness of clinical side effects for the specific determination and the need of anti-infection treatment. A perfect biomarker for bacterial pneumonic diseases ought to permit a quick conclusion, have a prognostic esteem and encourage restorative dynamic.. The mix of a few biomarkers reflecting distinctive pathophysiological pathways can possibly improve the administration of network gained pneumonia later on. I-Inclusion criteriaAll enrolled patients were:  Admitted in pediatric ward and PICU aged between 1 month and18 years old (both males and females).  Children with diagnosis of pneumonia. II-Exclusion criteriaAny patient was excluded from this study if:  Children with any chronic chest illness other than pneumonia .  patients with renal impairment.  Patients with liver impairment.  patients below one month and above 18 years. Study50 children aged from 2 months to 18 years with mean age (54.32± 39.53 (4-120) They were 28 males (56%) and 22 females(44%).Parental consent was granted in all cases and two children died after examination.Their diagnosis based on clinical, laboratory, radiological evaluation. MethodsAll studied patients have been subjected to the following: Demographic data including: I-Full history taking in the form of applied questionnaire includin Sample  Personal history: age, sex, residence.  Onset, duration of illness.  Presenting symptoms: fever, cough, tachypnea, cyanosis, recurrent attacks and congenital anomalies .  Medication received  Outcome 142 Copeptin as an Inflammatory Marker in Diagnosis and Prognosis of Community Acquired Benha Journal Of Applied Sciences, Vol.(5) Issue(5) Part (1) (2020) II -Full clinical examination in the form of:- General examination  General look Vital signs Temperature, heart rate, respiratory rate, blood pressure, capillary refill Oxygen saturation Anthropometric measurements (Head circumference, weight, height)  Systemic examination for  Cardiac systemInspection and palpation to detect the presence of pericardial bulge, pulsations and to examine apex.Auscultation: for heart sounds and audible murmur. Respiratory system Inspection: to detect retractions, chest movements and signs of respiratory distress.  palpation: for tracheal shift and palpable ronchi.  Auscultation: for air entry , breath sounds and advential sound(fine crepitations and wheez) Neurological examination  Assessment of conscious level by Galscow coma scale.  Examination of muscle power, tone and reflexes. Abdominal examination  Inspection: for abdominal distention  Palpation: for organomegaly (hepatomegaly and/ or splenomegaly)  Percussion: for ascites.  Auscultation: for intestinal sound III -Investigations Biochemical and hematological investigations: Measurement of  Complete blood count.  C-reactive protein.  Serum copeptin. 1. Complete blood count (CBC) was done for all samples using sysmex KX-21N (Sysmex Corporation, New York, USA) for red blood cell (RBC) count, hemoglob...

Asthma is a genuine worldwide medical issue. Individuals of any age in nations all through the world are influenced by this constant aviation route issue that when uncontrolled can put extreme cutoff points on day by day life and is now and then lethal, it is more common in youngsters than in grown-ups. It was accounted for that the predominance of asthma is increasing.The point of the examination was to decide the commonness pace of bronchial asthma in a preliminary to recognize the extent of the issue of asthma and to distinguish some of hazard factors expanding the pervasiveness of it among preschool kids from 2-6years old in Qalubyia Governorate utilizing the ISAAC survey, 1000 understudies were remembered for this investigation (475 were guys and 525were females). in the period from Novaber 2019 to April 2020.The consequences of this poll among examined youngsters (1000 kid) indicated that: 164 (16.4%) of considered understudies were asthmatics. Our investigation as respects sexual orientation and its connection to youth asthma demonstrated that, the predominance of asthma in male kids was 17.5% and in female youngsters was 15.4% and this distinction was measurably insignificant(P<0.05). days was increasingly regular in a time of 1-3 days. Determination: There was a high pervasiveness of asthma among kids. Asthma was found to influence rest of kids in a few viewpoints. The instructive degree of guardians had no impact on the predominance of asthma.

Background: Community-acquired pneumonia (CAP) is one of the most common causes of death among children all over the world, especially in the developing countries. Late diagnosis is one of the main causes for increasing morbidity and mortality. Non-invasive biomarkers could provide an early and non-invasive technique for both diagnosis and assessment of severity of pneumonia. Aim and objectives: The aim of the current study was to evaluate the mean platelet volume (MPV) and presepsin as diagnostic markers in childhood pneumonia and to estimate their reliability in assessing the severity of the disease. Subjects and methods: The study included 90 children who were distributed into three groups as follows, 30 healthy children as a control group, 30 cases with pneumonia and 30 cases with severe pneumonia. Full history taking, clinical examination and laboratory investigation (including measurement of serum presepsin and MPV) were conducted for every child. Results: The mean MPVin the control group was 7.94 ± 0.84 that was statistically significantly lower as compared with the cases with pneumonia (9.81 ± 0.97). Both groups had statistically significantly lower MPV as compared with the severe pneumonia group (10.7 ± 0.89) (p< 0.001). The mean presepsin level in the control group was 141.14 ± 71.4 that was statistically significantly lower as compared with the cases with pneumonia (605.80 ± 176.11). Both groups had statistically significantly lower Presepsin level as compared with the severe pneumonia group (1276.72 ± 1061.64) (p< 0.001). AUC of presepsin and MPV in identifying cases with pneumonia was (0.963 and 0.912 respectively) while AUC of presepsin and MPV in identifying cases with severe pneumonia was (0.877 and 0.789 respectively)