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Conclusions Systemic chemotherapy with TIP followed by salvage focal treatment is a promising therapeutic approach in selected patients, particularly in younger patients, without comorbidities, good performance status, low metastatic tumor burden, and with an objective response to chemotherapy.

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To compare structural condition of the bone tissue in the women with verified perinatal infection (vPI) and in healthy pregnant women in the dynamics of gestation. a prospective study in the dynamics of gestation has been performed in 363 pregnant women, 235 of them (group I – main group) with vPI. decrease in bone mineral density (BMd) have been identified already in the 2nd trimester. 128 healthy pregnant women formed control group (group II). ultrasound densitometry was used for the assessment of the structural state of bone tissue. BMd indexes matched normal only in 18.29 % (subgroup IB) of the pregnant women with vPI in the 2nd trimester of pregnancy. osteopenia was diagnosed in 71.91 % (subgroup Ia) in terms of BdI (78.07 ± 1.16) %, z-criterion – (–1.20 ± 0.04) Sd. at 9.78 % of the women under observation (subgroup IC: z-criterion (–2.65 ± 0.24) Sd, BdI – (56.35 ± 2.21) %) osteoporosis was diagnosed. BdI in vPI patients and normal values of BMd (sub- group IB) was (86.45 ± 0.74) %, z-criterion – (–0.90 ± 0.04) Sd. In the dynamics of gesta- tion there were significant losses of BMd in both groups, at vPI BMd losses were more pro- nounced. Probably, the syndrome of systemic inflammatory response may cause BMd loss or exacerbate an existing bone pathology.