It was known that heterocyclic compounds containing S and N have considerable importance which withdraw researchers attention due to their wide medical and biological applications. In the present investigation we have synthesized some oxadiazole derivatives (A 9-15 ), phthalazine derivatives (A 33-38 ) and Benzo thiazole-2-yl arylthiazol-4-one (A 17-24 ), thiazoles (A 39-41 ) from schiff base precursors. The thiazole compounds were cyclized using acetic anhydride, thioglycolic acid while phthalazines were cyclized using amylalcohol in HCl. The synthesized compounds were studied by IR,1HNMR spectral methods. ExperimentalPhenyl hydrazide (0.01mol.) or 3-Nitrophenyl hydrazide was dissolved in 25 ml of absolute ethanol. Aldehyde or its derivatives was then added. The reaction mixture was refluxed for 2 hours, cooled,stand for 3 hour at r.t. The p.p.t was filtered off and crystallized from ethanol, Physical and IR spectral data were shown in Tables 1,2.Synthesis of (substituted phenyl, substituted benzoyl hydrazonel(A 2-8

It is well known that pyrazolone derivatives possess antifungal and antibacterial activities. Pyrazole and isoxazole derivatives are widely used in medicinal chemistry. In continuation of our work on the synthesis of heterocycles containing the quinoline moiety we synthesized different heterocyclic sulfones related to quinolinol.